Quassia amara L. (Simaroubaceae) leaf tea: Effect of the growing stage and desiccation status on the antimalarial activity of a traditional preparation

Bertani, Stéphane; Houël, Emeline; Bourdy, Geneviève; Stien, Didier; Jullian, Valérie; Landau, I.; Deharo, Eric

doi:10.1016/j.jep.2006.10.028

Cited by 22 publications

(15 citation statements)

References 11 publications

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“…Although in theory it would be easy with high-throughput screening to test millions of combinations for potential anti-malarial synergy in vitro , this would miss any mechanisms which were dependent on metabolism (both pharmacodynamic synergy of metabolites, and pharmacokinetic synergy). For example dried Quassia amara leaf tea is much more active in vivo than in vitro [107]. …”

Section: Discussionmentioning

confidence: 99%

Whole plant extracts versus single compounds for the treatment of malaria: synergy and positive interactions

Rasoanaivo

Wright

Willcox

et al. 2011

Malar J

417

262

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BackgroundIn traditional medicine whole plants or mixtures of plants are used rather than isolated compounds. There is evidence that crude plant extracts often have greater in vitro or/and in vivo antiplasmodial activity than isolated constituents at an equivalent dose. The aim of this paper is to review positive interactions between components of whole plant extracts, which may explain this.MethodsNarrative review.ResultsThere is evidence for several different types of positive interactions between different components of medicinal plants used in the treatment of malaria. Pharmacodynamic synergy has been demonstrated between the Cinchona alkaloids and between various plant extracts traditionally combined. Pharmacokinetic interactions occur, for example between constituents of Artemisia annua tea so that its artemisinin is more rapidly absorbed than the pure drug. Some plant extracts may have an immunomodulatory effect as well as a direct antiplasmodial effect. Several extracts contain multidrug resistance inhibitors, although none of these has been tested clinically in malaria. Some plant constituents are added mainly to attenuate the side-effects of others, for example ginger to prevent nausea.ConclusionsMore clinical research is needed on all types of interaction between plant constituents. This could include clinical trials of combinations of pure compounds (such as artemisinin + curcumin + piperine) and of combinations of herbal remedies (such as Artemisia annua leaves + Curcuma longa root + Piper nigum seeds). The former may enhance the activity of existing pharmaceutical preparations, and the latter may improve the effectiveness of existing herbal remedies for use in remote areas where modern drugs are unavailable.

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Section: Discussionmentioning

confidence: 99%

Whole plant extracts versus single compounds for the treatment of malaria: synergy and positive interactions

Rasoanaivo

Wright

Willcox

et al. 2011

Malar J

417

262

View full text Add to dashboard Cite

show abstract

“…This included, especially, using the same plant parts as employed in the field, and extracting in water− the most common mode of preparation of medicinals (Coe, 1994(Coe, , 2008a(Coe, , 2008b(Coe, , 2008cCoe & Anderson, 1996a, 2008b, 1997. Plant crude extracts (stock solution) were prepared by boiling 1 g of plant material in 100 mL of distilled water as described by Bertani et al (2007); this was the stock solution. An appropriate amount of 1% NaCl solution was added to the stock solution to give concentrations of 500, 1000, 2500, 5000, 7500, and 10,000 µg/mL.…”

Section: Plant Crude Extract Preparationmentioning

confidence: 99%

The good and the bad: Alkaloid screening and brineshrimp bioassays of aqueous extracts of 31 medicinal plants of eastern Nicaragua

Coe

Parikh

Johnson

et al. 2011

Pharmaceutical Biology

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“…Most scientific studies on SKD have concentrated on developing SKD as an antimalarial agent [16,19,20]. However, there have been some in vitro studies regarding its cytotoxic activities at low concentrations (1.0 to 0.2 µM) in cancer cell lines such as KB (human epidermal carcinoma), P-388 (lymphocytic leukemia), BT-549 (human ductal carcinoma), MCF-7 (breast), SK-OV-3 (ovarian), and Vero cells [14,16,17,21,22].…”

Section: Potential Antiproliferative Activity Of Simalikalactone D (Skd)mentioning

confidence: 99%

Simalikalactone D, a Potential Anticancer Compound from Simarouba tulae, an Endemic Plant of Puerto Rico

Mendez

Reyes

Conde

et al. 2020

Plants

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Species of the genus Simarouba have been studied because of their antimalarial and antileukemic activities. A group of oxygenated terpenes called quassinoids have been isolated from species of the Simarouba genus, and are responsible for its therapeutic properties. We hypothesized that Simarouba tulae, an endemic plant from Puerto Rico, is a natural source rich in quassinoid compounds with anticancer activity. The leaves were processed and extracted with solvents of different polarities. The extracts were screened for their antiproliferative activity, and it was shown that the chloroform extract was the most active extract. This extract was purified using different chromatographic techniques to afford the quassinoid simalikalactone D (SKD). This compound was further characterized using NMR and X-ray diffraction analysis. A reassessment of original structural assignments for SKD is proposed. SKD showed high cytotoxicity activity, with an IC50 of 55, 58, and 65 nM in A2780CP20 (ovarian), MDA-MB-435 (breast), and MDA-MB-231 (breast) cell lines, respectively. Exposure to SKD led to 15% inhibition of the migration of MDA-MB-231 cells.

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Quassia amara L. (Simaroubaceae) leaf tea: Effect of the growing stage and desiccation status on the antimalarial activity of a traditional preparation

Cited by 22 publications

References 11 publications

Whole plant extracts versus single compounds for the treatment of malaria: synergy and positive interactions

Whole plant extracts versus single compounds for the treatment of malaria: synergy and positive interactions

The good and the bad: Alkaloid screening and brineshrimp bioassays of aqueous extracts of 31 medicinal plants of eastern Nicaragua

Simalikalactone D, a Potential Anticancer Compound from Simarouba tulae, an Endemic Plant of Puerto Rico

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