Quartz crystal microbalance immunosensor for the detection of antibodies to double-stranded DNA

Fakhrullin, Rawil; Винтер, В. Г.; Zamaleeva, Alsu I.; Matveeva, Maria V.; Kourbanov, Roustem A.; Temesgen, B. K.; Ishmuchametova, Dilara G.; Zi, Abramova; Коновалова, О. А.; Салахов, М. Х.

doi:10.1007/s00216-007-1230-2

Cited by 21 publications

(8 citation statements)

References 41 publications

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“…Other physical parameters can be measured in addition to the resonance frequency, such as motional resistance, which can be used to measure the viscoelastic change of the deposited film. The simultaneous measurements of resonance frequency and motional resistance can differentiate an elastic mass attachment from viscosity-induced effects: for an elastic mass attachment, the motional resistance will be zero and the resonance frequency will be proportional to the mass increase on the surface of the quartz crystal; when viscosity-induced effects are present, the decrease of resonance frequency is accompanied by a proportional increase of motional resistance (Fakhrullin et al, 2007).…”

Section: Quartz Crystal Microbalance Analysesmentioning

confidence: 99%

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Interactions between κ-carrageenan and chitosan in nanolayered coatings—Structural and transport properties

Pinheiro

Bourbon

Medeiros

et al. 2012

Carbohydrate Polymers

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The interactions between-carrageenan and chitosan, two oppositely charged polysaccharides, have been investigated through microcalorimetric and quartz crystal microbalance measurements. Microcalorimetric measurements show that-carrageenan/chitosan interaction is an exothermic process and that the alternate deposition of-carrageenan and chitosan results in the formation of a nanolayered coating mainly due to the electrostatic interactions existing between the two polyelectrolytes (though other types of interactions may also be involved). Quartz crystal microbalance measurements confirmed that the alternating deposition of-carrageenan and chitosan resulted in the formation of a stable multilayer structure. The-carrageenan/chitosan nanolayered coating, assembled on a polyethylene terephthalate (PET) support, was characterized in terms of its surface (contact angle measurements) and gas barrier properties (water vapor and O 2 permeabilities) and analyzed by scanning electron microscopy (SEM). The water vapor permeability (WVP) and the oxygen permeability (O 2 P) of the-carrageenan/chitosan nanolayers were found to be 0.020 ± 0.002 × 10 −11 and 0.043 ± 0.027 × 10 −14 g m −1 s −1 Pa −1 , respectively. These results contribute to a better understanding of the type of interactions that play role during the construction of this type of nanostructures. This knowledge can be used in the establishment of an approach to produce edible, biodegradable multilayered nanostructures with improved mechanical and barrier properties for application in, e.g. food and biomedical industries.

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Section: Quartz Crystal Microbalance Analysesmentioning

confidence: 99%

“…4b). The motional resistance represents the energy loss and the damping process within the system and is closely related to the physical properties of the adsorbed layers and adjacent liquid and its variation can be used to measure the viscoelastic change of the deposited film (Fakhrullin et al, 2007). From Fig.…”

Section: Quartz Crystal Microbalance Analysismentioning

confidence: 99%

Interactions between κ-carrageenan and chitosan in nanolayered coatings—Structural and transport properties

Pinheiro

Bourbon

Medeiros

et al. 2012

Carbohydrate Polymers

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“…Similarly, Fakhrullin et al developed a QCM immunosensor with the simultaneous measurement of resonance frequency and motional resistance for the detection of antibodies to double-stranded DNA [26].…”

Section: Conformational Dynamicsmentioning

confidence: 99%

New structural insights into the role of TROVE2 complexes in the on-set and pathogenesis of systemic lupus erythematosus determined by a combination of QCM-D and DPI

et al. 2018

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The mechanism of self-recognition of the autoantigen TROVE2, a common biomarker in autoimmune diseases, has been studied with Quartz Crystal Microbalance with Dissipation monitoring (QCM-D) and Dual Polarization Interferometry (DPI). The complementarity and remarkable analytical features of both techniques has allowed to achieve new insights onto the onset of systemic Lupus Erythematosus (SLE) at the molecular level. The in vitro study for SLE patients and healthy subjects suggests that anti-TROVE2 autoantibodies may undergo an antibody bipolar bridging. An epitope-paratope specific binding initially occurs to activate a hidden Fc-receptor in the TROVE2 tertiary structure. This bipolar mechanism may contribute to the pathogenic accumulation of anti-TROVE2 autoantibody immune complex in autoimmune disease. Furthermore, the specific calcium dependent protein-protein bridges point out at how the TRIM21:TROVE2 association might occur, suggesting that the TROVE2 protein could stimulate the intracellular immune signaling via the TRIM21 PRY-SPRY domain. These findings may help to better understand the origins of the specificity and affinity of TROVE2 interactions, which might play a key role in the SLE pathogenesis. This manuscript gives one of the first practical applications of two novel functions (df/dD and h/molec) for the analysis of the data provided by QCM-D and DPI. In addition, it is the first time that QCM-D has been used for mapping hidden Fc-receptors as well as linear epitopes in a protein tertiary structure.

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“…Sensitive and accurate biosensing systems for these biomarkers can not only significantly aid in the early diagnosis and clinical management of AIDs but also help to establish therapeutic strategies [ 4 ]. Biosensors for the detection of autoantibodies specific to AIDs, including antiphospholipid syndrome (APS) [ 91 , 92 , 93 , 94 ], rheumatoid arthritis (RA) [ 95 , 96 , 97 , 98 , 99 ], systemic lupus erythematosus (SLE) [ 100 , 101 , 102 , 103 , 104 , 105 , 106 , 107 ], multiple sclerosis (MS) [ 108 , 109 , 110 , 111 ], and celiac disease (CD) [ 112 , 113 , 114 , 115 , 116 , 117 , 118 , 119 , 120 , 121 , 122 , 123 , 124 ], are now constructed based on diverse techniques with many advantages, including high sensitivity and easy operation.…”

Section: Potential Applications Of Antibody Biosensing For Clinicamentioning

confidence: 99%

Construction and Potential Applications of Biosensors for Proteins in Clinical Laboratory Diagnosis

Jiang

2017

Sensors

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Biosensors for proteins have shown attractive advantages compared to traditional techniques in clinical laboratory diagnosis. In virtue of modern fabrication modes and detection techniques, various immunosensing platforms have been reported on basis of the specific recognition between antigen-antibody pairs. In addition to profit from the development of nanotechnology and molecular biology, diverse fabrication and signal amplification strategies have been designed for detection of protein antigens, which has led to great achievements in fast quantitative and simultaneous testing with extremely high sensitivity and specificity. Besides antigens, determination of antibodies also possesses great significance for clinical laboratory diagnosis. In this review, we will categorize recent immunosensors for proteins by different detection techniques. The basic conception of detection techniques, sensing mechanisms, and the relevant signal amplification strategies are introduced. Since antibodies and antigens have an equal position to each other in immunosensing, all biosensing strategies for antigens can be extended to antibodies under appropriate optimizations. Biosensors for antibodies are summarized, focusing on potential applications in clinical laboratory diagnosis, such as a series of biomarkers for infectious diseases and autoimmune diseases, and an evaluation of vaccine immunity. The excellent performances of these biosensors provide a prospective space for future antibody-detection-based disease serodiagnosis.

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Quartz crystal microbalance immunosensor for the detection of antibodies to double-stranded DNA

Cited by 21 publications

References 41 publications

Interactions between κ-carrageenan and chitosan in nanolayered coatings—Structural and transport properties

Interactions between κ-carrageenan and chitosan in nanolayered coatings—Structural and transport properties

New structural insights into the role of TROVE2 complexes in the on-set and pathogenesis of systemic lupus erythematosus determined by a combination of QCM-D and DPI

Construction and Potential Applications of Biosensors for Proteins in Clinical Laboratory Diagnosis

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