In this paper, we use the WKB approximation method to approximately solve a deformed Schrodinger-like differential equation:, which are frequently dealt with in various effective models of quantum gravity, where the parameter α characterizes effects of quantum gravity. For an arbitrary function g (x) satisfying several properties proposed in the paper, we find the WKB solutions, the WKB connection formulas through a turning point, the deformed Bohr-Sommerfeld quantization rule, and the deformed tunneling rate formula through a potential barrier. Several examples of applying the WKB approximation to the deformed quantum mechanics are investigated. In particular, we calculate the bound states of the Pöschl-Teller potential and estimate the effects of quantum gravity on the quasinormal modes of a Schwarzschild black hole. Moreover, the area quantum of the black hole is considered via Bohr's correspondence principle. Finally, the WKB solutions of the deformed Wheeler-DeWitt equation for a closed Friedmann universe with a scalar field are obtained, and the effects of quantum gravity on the probability of sufficient inflation is discussed in the context of the tunneling proposal.