Quantum mechanical model for the anticarcinogenic effect of extremely-low-frequency electromagnetic fields on early chemical hepatocarcinogenesis

Abstract

Using the conventional Haberkorn approach, it is evaluated the recombination of the radical pair (RP) singlet spin state to study theoretically the cytoprotective effect of an extremely-low-frequency electromagnetic field (ELF-EMF) on early stages of hepatic cancer chemically induced in rats. The proposal is that ELF-EMF modulates the interconversion rate of singlet and triplet spin states of the RP populations modifying the products from the metabolization of carcinogens. Previously, we found that the daily treatment with ELF-EMF 120 Hz inhibited the number and area of preneoplastic lesions in chemical carcinogenesis. The singlet spin population is evaluated diagonalizing the spin density matrix through the Lanczos method in a radical pair mechanism (RPM). Using four values of the interchange energy, we have studied the variations over the singlet population. The low magnetic field effect as a test of the influence over the enzymatic chemical reaction is evaluated calculating the quantum yield. Through a bootstrap technique the range is found for the singlet decay rate for the process. Applying the quantum measurements concept, we addressed the impact toward hepatic cells. The result contributes to improving our understanding of the chemical carcinogenesis process affected by charged particles that damage the DNA.

Cytoprotective Effect of 120 Hz Electromagnetic Fields on Early Hepatocarcinogenesis: Experimental and Theoretical Findings

“…In our research group, we have implemented the use of an ELF-EMF to study hepatocarcinogenesis in its early stages to assess its cytoprotective effect, both experimentally and theoretically. We proposed that it is possible to deter the carcinogenic process induced by chemical carcinogens in the early stages during enzymatic procarcinogen activation by CYP450 through the modulation of charge migration in the electron transfer reactions involved in oxidation [8,9]. This has been achieved by modulating the magnetic sensitivity of short-lived RP intermediaries produced during the catalytic cycle using ELF-EMF.…”

“…In this chapter, we review the experimental and theoretical findings found by our research group within the context of the current knowledge on the cytoprotective effect of ELF-EMF in the early stages of OS induced by chemical carcinogenesis (ChemCar). We use the term cytoprotection because of the conferred protection that dissuades or modulates, controls, or deviates processes originated from bioactivation of procarcinogens, which avoids or diminishes damage to cells or its molecular components [8,9]. On the one hand, we describe and discuss the experimental findings of our group on the effect of daily treatment with 4.5 mT (120 Hz) of ELF-EMF.…”

“…It is plausible to assume that, through the employment of RPM using ELF-EMF, we modulated the RP intermediates involved in free radical generation (as has been reported for other reactions [11]). Then, directing them towards lower energetic states in such a way that the activation of oxidative products diminished, and the electrophile damage to cells is reduced [9]. Thanks to this multidisciplinary analysis, we can understand the carcinogenic chemical process based on the behavior of charged particles generated during the enzymatic activation of the procarcinogen, that is, when the DNA still has not yet been damaged in the early stages of carcinogenesis [8,9].…”

“…Then, directing them towards lower energetic states in such a way that the activation of oxidative products diminished, and the electrophile damage to cells is reduced [9]. Thanks to this multidisciplinary analysis, we can understand the carcinogenic chemical process based on the behavior of charged particles generated during the enzymatic activation of the procarcinogen, that is, when the DNA still has not yet been damaged in the early stages of carcinogenesis [8,9]. The results of this work allow us to advertise the basis for the design of tailored therapeutic strategies or clinical applications of ELF-EMF as a coadjutant in the treatment of several diseases related to oxidative damage as occurs in cancer [8,9].…”

“…Thanks to this multidisciplinary analysis, we can understand the carcinogenic chemical process based on the behavior of charged particles generated during the enzymatic activation of the procarcinogen, that is, when the DNA still has not yet been damaged in the early stages of carcinogenesis [8,9]. The results of this work allow us to advertise the basis for the design of tailored therapeutic strategies or clinical applications of ELF-EMF as a coadjutant in the treatment of several diseases related to oxidative damage as occurs in cancer [8,9]. The importance of the use of ELF-EMF-based therapies is precisely their low cost, safety, effectiveness, and their implication on the homeostasis of the biological systems (BS).…”