Quantum-enhanced nonlinear microscopy

Casacio, Catxere A.; Madsen, Lars S.; Terrasson, Alex; Waleed, Muhammad; Barnscheidt, Kai; Hage, B.; Taylor, Michael A.; Bowen, Warwick P.

doi:10.1038/s41586-021-03528-w

Cited by 191 publications

(210 citation statements)

References 48 publications

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“…Nevertheless, these methods appear promising because of the fast occurring technological advances in SP detectors' time resolution and should be investigated more in the space of CCs, for example, in hBN, where the concentration of single emitters and blinking properties are favorable to quantum-enhanced-SMLM. In addition, other quantum light-based methods 172 relying on quantum correlation have improved the signal-to-noise ratio in a coherent Raman microscope revealing molecular bonds within a cell, thus providing subdiffraction resolution. Such a nonlinear microscope enhanced by quantum correlation may apply to CCs in diamond or other point defects imaging.…”

Section: Discussionmentioning

confidence: 99%

Color centers in wide-bandgap semiconductors for subdiffraction imaging: a review

Castelletto

Boretti

2021

Adv. Photon.

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Solid-state atomic-sized color centers in wide-band-gap semiconductors, such as diamond, silicon carbide, and hexagonal boron nitride, are important platforms for quantum technologies, specifically for single-photon sources and quantum sensing. One of the emerging applications of these quantum emitters is subdiffraction imaging. This capability is provided by the specific photophysical properties of color centers, such as high dipole moments, photostability, and a variety of spectral ranges of the emitters with associated optical and microwave control of their quantum states. We review applications of color centers in traditional super-resolution microscopy and quantum imaging methods, and compare relative performance. The current state and perspectives of their applications in biomedical, chemistry, and material science imaging are outlined.

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Section: Discussionmentioning

confidence: 99%

Color centers in wide-bandgap semiconductors for subdiffraction imaging: a review

Castelletto

Boretti

2021

Adv. Photon.

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“…This is interesting because it implies that for a fixed mean photon number N in the probe mode, a relatively high intensity (high probe state rate or large ν) is needed for studying interactions that result in a small sensorgram deviation. If the biosystems (receptors and ligands) being studied are fragile to such a high intensity it would potentially add extra noise to the measurements and make them less precise [72][73][74], an effect recently observed for 3µm polystyrene beads [75]. The sensor itself may also impart additional noise or nonlinear behavior at a high intensity [11,76].…”

Section: E Threshold Intensitymentioning

confidence: 99%

Experimental measurement of kinetic parameters using quantum plasmonic sensing

Mpofu

Lee

Maguire

et al. 2022

Journal of Applied Physics

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Kinetic models are essential for describing how molecules interact in a variety of biochemical processes. The estimation of a model’s kinetic parameters by experiment enables researchers to understand how pathogens, such as viruses, interact with other entities like antibodies and trial drugs. In this work, we report a simple proof-of-principle experiment that uses quantum sensing techniques to give a more precise estimation of kinetic parameters than is possible with a classical approach. The interaction we study is that of bovine serum albumin (BSA) binding to gold via an electrostatic mechanism. BSA is an important protein in biochemical research as it can be conjugated with other proteins and peptides to create sensors with a wide range of specificity. We use single photons generated via parametric down-conversion to probe the BSA–gold interaction in a plasmonic resonance sensor. We find that sub-shot-noise-level fluctuations in the sensor signal allow us to achieve an improvement in the precision of up to 31.8% for the values of the kinetic parameters. This enhancement can, in principle, be further increased in the setup. Our work highlights the potential use of quantum states of light for sensing in biochemical research.

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“…In the biomedical field, label-free analysis involving classical illumination is usually considered a noninvasive approach. However, recent evidence shows that, for some applications, even relatively low classical light levels suffice to induce changes in the sample, ranging from permanent photodamage ( 6 ) to more subtle alterations that, nonetheless, affect measurement accuracy ( 7 ). Photosensitivity must also be taken into account when probing fragile quantum gas states ( 8 ) or atomic ensembles ( 9 ).…”

Section: Introductionmentioning

confidence: 99%