Quantum dot-based immunochromatography test strip for rapid, quantitative and sensitive detection of alpha fetoprotein

Yang, Qiuhua; Gong, Xiaoqun; Song, Tao; Yang, Jiumin; Zhu, S.; Li, Yunhong; Cui, Yun; Li, Yingxin; Zhang, Bingbo; Chang, Jin

doi:10.1016/j.bios.2011.09.002

Cited by 166 publications

(81 citation statements)

References 39 publications

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“…Furthermore, the fluorescent materials enable lateral flow assay to detect the target quantitatively. Compared with colloid gold, which can only provide qualitative or semiquantitative results, quantitative detection can offer more information [42,51,52]. In particular, quantum dots show unique fluorescence properties, such as high and stable fluorescence signal [53][54][55].…”

Section: Quantum Dots As Labelmentioning

confidence: 99%

Current and Emerging Technologies for Rapid Detection of Pathogens

Zeng¹,

Wang²,

Hu³

2018

Biosensing Technologies for the Detection of Pathogens - A Prospective Way for Rapid Analysis

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Foodborne diseases, caused by pathogenic bacteria, have become an important social issue in the field of food safety. It presents a widespread and growing threat to human health in both developed and developing countries. As such, techniques for the detection of foodborne pathogens and waterborne pathogens are urgently needed to prevent the occurrence of human foodborne infections. Although traditional culture-based bacterial isolation and identification are the "gold standard" methods with high preciseness, their drawbacks in time-consuming are inadequate for rapid detection of pathogen to reduce foodborne disease occurrence. Fortunately, with the development of biotechnologies and nanotechnologies, various kinds of new technologies for rapid detection of pathogens have been developed so far, such as nucleic acid-based methods, antibody-based methods, and aptamer-based assays. In this chapter, we summarized the principles and the application of some recent rapid detection technologies for pathogenic bacteria. Moreover, the advantages and disadvantages of the established and emerging rapid detection methods are addressed here.

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Section: Quantum Dots As Labelmentioning

confidence: 99%

Current and Emerging Technologies for Rapid Detection of Pathogens

Zeng¹,

Wang²,

Hu³

2018

Biosensing Technologies for the Detection of Pathogens - A Prospective Way for Rapid Analysis

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“…[1][2][3][4][5][6][7][8][9] Among them, paper-based POC devices are a special category due to the advantages of being simple, rapid, on-site, and cost-effective; they have been widely used in home health care and medical testing, [10][11][12] even environmental monitoring. [13][14][15] The lateral flow immunochromatographic assay, also called lateral flow test, is one of the simplest and most popular formats of paper-based POC devices and can be used to detect specific substances, including small molecules, [15][16][17][18] large proteins, [19][20][21] and even whole pathogens, 10 in a sample by using an immunological reaction. However, most of these tests are based on qualitative colorimetry, which is not sufficient in many cases.…”

Section: Introductionmentioning

confidence: 99%

Biosensing of DNA oxidative damage: a model of using glucose meter for non-glucose biomarker detection

Zhu¹,

Sarwar²,

Yue³

et al. 2017

IJN

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Non-glucose biomarker-DNA oxidative damage biomarker 8-hydroxy-2′-deoxyguanosine (8-OHdG) has been successfully detected using a smartphone-enabled glucose meter. Through a series of immune reactions and enzymatic reactions on a solid lateral flow platform, 8-OHdG concentration has been converted to a relative amount of glucose, and therefore can be detected by conventional glucose meter directly. The device was able to detect 8-OHdG concentrations in phosphate buffer saline as low as 1.73 ng mL −1 with a dynamic range of 1–200 ng mL −1 . Considering the inherent advantages of the personal glucose meter, the demonstration of this device, therefore, should provide new opportunities for the monitoring of a wide range of biomarkers and various target analytes in connection with different molecular recognition events.

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“…Labels for immunorecognition events were reported to produce electrochemical signals and to enhance the sensitivity, including gold nanoparticle, 12 quantum dot, [13][14][15][16] enzyme, [17][18][19][20] and liposome. 21 However, labels accumulated in the region immobilized with some antibodies must be transferred to an electrochemical cell to convert the labels to the electrochemical signal.…”

Section: Introductionmentioning

confidence: 99%

A Dual Electrochemical Sensor Based on a Test-strip Assay for the Quantitative Determination of Albumin and Creatinine

2015

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A dual-electrochemical sensor based on a test-strip assay with immunochemistry and enzyme reactions has been developed for the determination of albumin and creatinine. Each nitrocellulose membrane with an immobilization area of an anti-albumin antibody or three enzymes was prepared in the device with three working electrodes for measuring albumin, creatinine, and ascorbic acid, as well as an Ag/AgCl electrode used as a counter/pseudo-reference electrode. The reactions of three enzymes were initiated by flowing a solution containing creatinine to detect an oxidation current of hydrogen peroxide. A sandwich-type immunocomplex was formed by albumin and antibody labeled with glucose oxidase (GOx). Captured GOx catalyzed the reduction of Fe(CN)6 3-to Fe(CN)6 4-, which was oxidized electrochemically to determine the captured albumin. The responses for creatinine and albumin increased with the concentrations in millimolar order and over the range 18.75 -150 μg mL -1 , respectively. The present sensor would be a distinct demonstration for producing quantitative dual-assays for various biomolecules used for clinical diagnoses.

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Quantum dot-based immunochromatography test strip for rapid, quantitative and sensitive detection of alpha fetoprotein

Cited by 166 publications

References 39 publications

Current and Emerging Technologies for Rapid Detection of Pathogens

Current and Emerging Technologies for Rapid Detection of Pathogens

Biosensing of DNA oxidative damage: a model of using glucose meter for non-glucose biomarker detection

A Dual Electrochemical Sensor Based on a Test-strip Assay for the Quantitative Determination of Albumin and Creatinine

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