Quantitative ultrastructural analysis of hepatoprotective effects of (+)-cyanidanol-3 on alcoholic liver damage

Varga, M.; Buris, László

doi:10.1016/0014-4800(90)90010-b

Cited by 14 publications

(6 citation statements)

References 24 publications

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“…Ethanol also fluidizes membrane lipids to influence the membrane functions [33,34]. Morphological and biochemical alterations in hepatocytes induced by carbon tetrachloride and ethanol are prevented by C [12][13][14]. In pharmacokinetic studies, C achieves the maximal concentrations over Ìmol/l in blood after oral administration of C and green tea extracts [15,16,19].…”

Section: Discussionmentioning

confidence: 99%

“…Liver is experimentally damaged by hapatotoxic chlorinated hydrocarbons and ethanol [12,14,30,31]. Chloroform decreased fluorescence polarization of DPPC liposomes measured with ANS and PNA to enhance the fluidity of hydrophilic and hydrophobic regions in membranes.…”

Section: Discussionmentioning

confidence: 99%

“…C is effective for viral, alcoholic and experimental liver damage [9,10,[12][13][14]. Liver is experimentally damaged by hapatotoxic chlorinated hydrocarbons and ethanol [12,14,30,31].…”

Section: Discussionmentioning

confidence: 99%

“…Catechin also shows a protective effect on mammalian hepatic cells, leading to its therapeutic use for hepatitis [9,10]. The catechin incorporated in cell membranes was shown to prevent or reduce the morphological and biochemical alterations of hepatocytes induced by hepatotoxic agents [12][13][14]. The pharmacological mechanism underlying the antiplaque and hepatoprotective effects of catechins has been unclear despite evaluation of their clinical usefulness.…”

Section: Introductionmentioning

confidence: 99%

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Effects of Green Tea Catechins on Membrane Fluidity

Tsuchiya¹

1999

Pharmacology

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Catechins originating from green tea have been used in plaque inhibition for caries prevention and treatment for liver damage because of their antibacterial activity against cariogenic bacteria and protective activity on hepatic cells. The effects of catechins on membrane fluidity were studied by a fluorescence polarization method using liposomes prepared with dipalmitoylphosphatidylcholine and dioleoylphosphatidylcholine to assess their pharmacological mechanism at μmol/l levels found in human body fluids after clinical application. All eight catechins tested, ranging from 1 to 1,000 μmol/l, significantly reduced membrane fluidity in both hydrophilic and hydrophobic regions of lipid bilayers. Catechin gallate esters were superior in fluidity reduction to the corresponding nonesters. The fluidity-reducing degree was different between the cis and trans forms, suggesting the stereospecific activity of catechins. A reference antiplaque agent, chlorhexidine, similarly reduced membrane fluidity at the antibacterial concentration. (+)-Catechin (250 μmol/l) and (–)-epigallocatechin gallate (2.5 μmol/l) significantly prevented the membrane fluidization induced by hepatotoxic chloroform. These results indicate that the reduction in membrane fluidity is responsible for the antiplaque and hepatoprotective effects of green tea catechins.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

“…C is effective for viral, alcoholic and experimental liver damage [9,10,[12][13][14]. Liver is experimentally damaged by hapatotoxic chlorinated hydrocarbons and ethanol [12,14,30,31].…”

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Effects of Green Tea Catechins on Membrane Fluidity

Tsuchiya¹

1999

Pharmacology

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“…The antioxidant properties are manifested by ability to block free radical generation, to inhibit free radicals and to chelate heavy metal ions which otherwise can be free radical reaction catalysts (Guo et al, 1996;Jovanovic et al, 1995;Perrissoud et al, 1981). Catechins contained in green tea prevent oxygen-containing radical formation by blocking enzymes involved in their formation (Varga and Buris, 1990;Saija et al, 1995).…”

Section: Discussionmentioning

confidence: 99%

Influence of green tea on surface charge density and phospholipids composition of erythrocytes membrane in ethanol intoxicated rats

et al. 2005

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Ethanol is oxidized to acetaldehyde and then to acetic acid and these processes are accompanied by free radical generation. This paper reports the effect of green tea on electric charge and phospholipids composition of erythrocytes membrane from rats intoxicated with ethanol. Electrophoresis technique and HPLC have been applied to above-mentioned studies. Ethanol administration caused increase in erythrocyte membrane surface charge density and phospholipid composition. Ingestion of green tea with ethanol partially prevented changes in structure and function of membrane caused by chronic ethanol intoxication.

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Nutraceutical Potential of Indigenous Plant Foods and Herbs for Treatment of Alcohol-Related Liver Damage

Agte

Gumaste²

2012

Alcohol, Nutrition, and Health Consequences

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Quantitative ultrastructural analysis of hepatoprotective effects of (+)-cyanidanol-3 on alcoholic liver damage

Cited by 14 publications

References 24 publications

Effects of Green Tea Catechins on Membrane Fluidity

Effects of Green Tea Catechins on Membrane Fluidity

Influence of green tea on surface charge density and phospholipids composition of erythrocytes membrane in ethanol intoxicated rats

Nutraceutical Potential of Indigenous Plant Foods and Herbs for Treatment of Alcohol-Related Liver Damage

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