Quantitative ultrasound and risk of fractures in elderly women

Oliveira, Patrícia Pereira de; Marinheiro, Lizanka Paola Figueiredo; Wender, Maria Celeste Osório; Mendes, Jackson Bossoni; Roisenberg, Felipe

doi:10.1016/s2255-4823(11)70129-1

Cited by 2 publications

(3 citation statements)

References 22 publications

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“…In fact, BMD increases during growth and reaches its maximum value once the physiological growth process has been completed (Peak Bone Mass, PBM), followed by a period of stabilization and then a physiological decrease (NIH Consensus Development Panel on Osteoporosis Prevention, Diagnosis, 2001; Weaver et al, 2016). Males and females differ in mean BMD and PBM from puberty, with the greatest divergence starting after 40–50 years of age due to the strong menopausal‐related bone resorption processes in women (de Oliveira et al, 2011; Dede & Callan, 2018; Steadman, 2005; Weaver et al, 2016).…”

Section: Introductionmentioning

confidence: 99%

“…Osteoporotic fractures cause higher morbidity, increased risk of other fractures, as well as chronic pain, disability, and a higher risk of dying (de Oliveira et al., 2011; Johnell & Kanis, 2006; Nazrun et al, 2014; Odén et al, 2015). For these reasons, osteoporosis is considered one of the major contemporary health burdens and a current global pandemic (Golob & Laya, 2015b; Madimenos et al, 2015; Oden et al, 2015), although it is known that these disorders have affected human populations since ancient times.…”

Section: Introductionmentioning

confidence: 99%

“…A recent study has shown the potential of phalangeal Quantitative Ultrasonometry (QUS) for diagnosing osteoporosis on skeletal remains (Rinaldo et al, 2018). QUS is a reliable, portable, user‐friendly, and computer‐assisted clinical technique based on ultrasound waves propagation (Agnollitto et al, 2021; Baroncelli, 2008; Drozdzowska et al, 2005; Giavaresi et al, 2004; Guglielmi et al, 2015; Guglielmi & de Terlizzi, 2009; Hadji et al, 2015; Montagnani et al, 2000; Njeh et al, 1997; de Oliveira et al, 2011; Wüster et al, 2009, Wüster et al, 2005), which has never been applied before on forensic or archeological skeletal remains. In the paper of Rinaldo et al (2018), a protocol specifically adapted for skeletal remains and new reference curves were developed using a sample of 110 skeletons of known age and sex.…”

Section: Introductionmentioning

confidence: 99%

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Technical note: Application and potentiality of quantitative ultrasonometry for the evaluation of bone mineral density status

Pasini

Rinaldo

Bramanti

et al. 2023

American Journal of Biological Anthropology

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The evaluation of bone mineral density (BMD) is an important task in paleopathology. Techniques commonly applied in bone quantity assessment, such as DXA or radiogrammetry (XR), suffer from several limitations when applied to skeletal remains. In recently published research, we developed a new methodology and new reference curves for the evaluation of BMD on human skeletal remains, applying for the first time Quantitative Ultrasonometry (QUS), a user‐friendly, portable, and reliable clinical technique. This study aims to apply this new methodology to an archeological sample and to compare the results with those obtained through XR. We apply QUS and XR to a sample of 104 adults from Medieval Italian cemeteries. Fragility fractures were recorded. Descriptive statistics and comparisons between sexes, age‐at‐death cohorts, and individuals with and without fragility fractures were performed. Moreover, univariate and multivariate logistic regression models were used to define the parameters most predictive of fracture risk in past populations. The comparison between sexes showed no significant results concerning BMD parameters, whereas a decrease in BMD with increasing age is confirmed. The comparison between fracture and non‐fracture individuals and the logit model demonstrated that QUS parameters, especially UBPI, are more reliable predictors of fracture risk in comparison to XR. Our results confirmed that QUS is a valuable technique that can be efficiently applied to archeological remains, also considering its portability. We also propose a modification of the previously published QUS standard curves, to easily assess osteopenia and osteoporosis in archeological material.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Technical note: Application and potentiality of quantitative ultrasonometry for the evaluation of bone mineral density status

Pasini

Rinaldo

Bramanti

et al. 2023

American Journal of Biological Anthropology

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Correlation between ultrasound velocity and densitometry in fresh and demineralized cortical bone

Mesquita¹,

Barbieri²,

Barbieri³

2016

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OBJECTIVE:To compare ultrasound propagation velocity with densitometry in the diaphyseal compact cortical bone of whole sheep metatarsals.METHODS:The transverse ultrasound velocity and bone mineral density of 5-cm-long diaphyseal bone segments were first measured. The bone segments were then divided into four groups of 15 segments each and demineralized in an aqueous 0.5 N hydrochloric acid solution for 6, 12, 24 or 36 hours. All measurements were repeated after demineralization for each time duration and the values measured before and after demineralization were compared.RESULTS:Ultrasound velocity and bone mineral density decreased with demineralization time, and most differences in the pre- and post-demineralization values within each group and between groups were significant: A moderate correlation coefficient (r=0.75956) together with a moderate agreement was determined between both post-demineralization parameters, detected by the Bland-Altman method.CONCLUSION:We conclude that both ultrasound velocity and bone mineral density decrease as a result of demineralization, thus indicating that bone mineral content is of great importance for maintaining the acoustic parameters of cortical bone, as observed for cancellous bone. Ultrasound velocity can be used to evaluate both compact cortical bone quality and bone mineral density.

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Quantitative ultrasound and risk of fractures in elderly women

Cited by 2 publications

References 22 publications

Technical note: Application and potentiality of quantitative ultrasonometry for the evaluation of bone mineral density status

Technical note: Application and potentiality of quantitative ultrasonometry for the evaluation of bone mineral density status

Correlation between ultrasound velocity and densitometry in fresh and demineralized cortical bone

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