Quantitative Trait Loci Mapping and The Genetic Basis of Heterosis in Maize and Rice

Garcia, Antônio Augusto Franco; Wang, Shengchu; Melchinger, Albrecht E.; Zeng, Zhao‐Bang

doi:10.1534/genetics.107.082867

Cited by 146 publications

(133 citation statements)

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“…However, previous studies have shown that a conclusion on the genetic basis of heterosis depends on a statistical approach adopted by [8,16,17,36]. Therefore, the development and choice of appropriate methodology for NCIII design are critical.…”

Section: Discussionmentioning

confidence: 99%

“…Therefore, the development and choice of appropriate methodology for NCIII design are critical. In Stuber et al [19] and Xiao et al [22], the separate analysis on each backcross population actually estimated d*+a* or d*−a* [11,14,16]. To overcome this issue, Cockerham and Zeng [11] separated the additive and dominance effects in their combined analysis.…”

Section: Discussionmentioning

confidence: 99%

“…To overcome this issue, Cockerham and Zeng [11] separated the additive and dominance effects in their combined analysis. However, their single marker analysis method could not separate multiple linked gene effects and did not provide exact location of the QTL [11,16]. Based on this situation, Lu et al [12] and Ledeaux et al [28] developed the use of composite interval mapping [27] on each backcross separately and, after QTL are mapped in one or both backcrosses, a* and d* effects were estimated by a linear combination of the contrasts for each backcross according to the derivations of Cockerham and Zeng [11].…”

Section: Discussionmentioning

confidence: 99%

“…Heterosis represents one of the most revolutionary advancements in crop improvement, i.e., maize [8] and rice [4]. In the genetic dissection of heterosis, NCIII design, proposed by Comstock and Robinson [9,10], is one of the most powerful and widely used mating schemes [11][12][13][14][15][16][17]. Therefore, the importance of heterosis necessitates an in-depth study of the NCIII design.…”

mentioning

confidence: 99%

“…Therefore, Garcia et al [16] developed a multiple-interval mapping [31] model in the NCIII design. The method provides a platform to estimate the number, genomic positions, augmented additive and dominance effects, and epistatic interactions (aa+dd and ad+da) of QTL simultaneously.…”

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confidence: 99%

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Genome-wide mapping of QTL associated with heterosis in the RIL-based NCIII design

Zhang

2012

Chin. Sci. Bull.

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Heterosis represents one of the most revolutionary advancements in crop improvement. In the genetic dissection of heterosis, NCIII design is one of the most powerful and widely used mating schemes. However, the methodologies for quantitative trait loci (QTL) detection in the design were mostly based on composite interval mapping. Therefore, in this study, our purpose was to develop a statistical method for mapping epistatic QTL associated with heterosis in the RIL-based NCIII design. First, we derivated the expectations of two classical linear transformations, Z 1 and Z 2 , while a quantitative trait was controlled by two QTL with digenic epistasis and arbitrary linkage under the F ∞ and F 2 metric models. Then, we constructed an epistatic genetic model that includes all markers on the whole genome simultaneously, and estimated all the parameters in the model by the empirical Bayes approach. Finally, a series of Monte Carlo simulation experiments was carried out to confirm the proposed approach. The results show that: (1) all the augmented genetic parameters for main-effect QTL could be rightly identified with satisfactory statistical power and precision; (2) the statistical powers in the detection of augmented epistatic effects were substantively affected by the signs of pure epistatic effects; (3) it is more difficult to detect epistatic QTL than to detect main-effect QTL; (4) statistical power is higher in the RIL-based NCIII design than in the F 2 -based NCIII design, especially in the detection of the augmented epistatic effect that consists of two pure epistatic effects in opposite directions.empirical Bayes, epistasis, NCIII design, heterosis, quantitative trait locus, recombinant inbred line Citation:He X H, Hu Z L, Zhang Y M. Genome-wide mapping of QTL associated with heterosis in the RIL-based NCIII design.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

mentioning

confidence: 99%

mentioning

confidence: 99%

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Genome-wide mapping of QTL associated with heterosis in the RIL-based NCIII design

Zhang

2012

Chin. Sci. Bull.

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Heterosis and inheritance studies on morphological and chemical characters of tobacco

Kınay

Kurt

2022

Agronomy Journal

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Hybrid breeding provides excellent convenience in obtaining products that meet the demands of producers and the market. This study aimed to develop new hybrid tobacco (Nicotiana spp.) varieties that meet the demands of tobacco producers and buyers to provide continuity in homogenous products and genetically to determine the effects of parameters investigated. In this study, five parentsand Bozcakaldere [P5]) with different characters and 10 hybrid genotypes obtained from the five parents were tested in five different locations in Aktekke in 2018, and Aktekke, Kelikler, Seyhulas, and Huseyinbeyli in 2019. The morphological and chemical parameters of genotypes were significantly (p < .05 and p < .01) different from each other. The average leaf width, leaf length, nicotine content, yield, and phenolic contents of the hybrids were higher than those of the parents (respectively hybrids and parents; 17.2-15.3 cm, 29.6-27.1 cm, 0.81-0.72%, 1,982-1,720 kg ha -1 , 9.30-8.26 g kg -1 ). The results can be attributed to the slight influence of environmental factors and the high performance of hybrids. The results showed that especially the effect of leaf width on yield is higher than the leaf length and number of leaves, and the leaf is more important in terms of heredity. In addition, the results revealed that the nicotine ratio could be used as the primary selection criteria and the reducing sugar ratio as the main selection criteria for the next generations. Tobacco yield and quality grade index of P1×P3, P1×P4, and P1×P5 hybrids (respectively 2,030, 2,050, 2,060 kg ha -1 and 56, 52, 55%) were higher compared with the other hybrids.

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Genomewide marker estimates of the level of dominance in maize heterosis

Sweet,

Lorenzana,

Bernardo

2024

Crop Science

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Heterosis is the superiority of an F1 hybrid over its parents, and overdominance and dominance are the two main hypotheses for the genetic basis of heterosis. Our objectives were to determine if genomewide marker effects accurately reflect the level of dominance at quantitative trait loci (QTL) and assess the distribution of per‐marker estimates of the level of dominance in maize (Zea mays L.). We simulated different levels of dominance at QTL that were in coupling, repulsion, and random linkage phases. Genomewide marker effects from ridge regression‐best linear unbiased prediction led to accurate estimates of the level of dominance when all linkages were in coupling phase, but repulsion and random linkage phases led to an upward bias. We then estimated levels of dominance from genomewide marker effects in a reciprocal testcross experiment with 1642 hybrids genotyped with 4805 single nucleotide polymorphism markers, and in a legacy Design III experiment with 351 backcross progenies (subjected to three generations of random mating to dissipate linkages) genotyped with 160 simple sequence repeats. In both experiments, the level of dominance was higher for yield than for moisture. For each trait, some loci showed little or no dominance, others showed partial to complete dominance, and others showed overdominance. A high level of dominance was typically due to a small difference between homozygote values. Overall, the results were consistent with previous QTL mapping results indicating that heterosis in maize is due to varying levels of dominance rather than a prevalent level of dominance.

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Quantitative Trait Loci Mapping and The Genetic Basis of Heterosis in Maize and Rice

Cited by 146 publications

References 31 publications

Genome-wide mapping of QTL associated with heterosis in the RIL-based NCIII design

Genome-wide mapping of QTL associated with heterosis in the RIL-based NCIII design

Heterosis and inheritance studies on morphological and chemical characters of tobacco

Genomewide marker estimates of the level of dominance in maize heterosis

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