Quantitative susceptibility mapping shows lower brain iron content in children with attention‐deficit hyperactivity disorder

Tang, Shilong; Zhang, Guanping; Ran, Qiying; Nie, Lisha; Liu, Xianfan; Pan, Zhengxia; He, Ling

doi:10.1002/hbm.25798

Cited by 11 publications

(5 citation statements)

References 40 publications

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“…Recent studies suggest that dysregulation of ferroptosis may be closely related to the pathogenesis of neurological disorders including neurodegenerative diseases, strokes and glioma [ 58–60 ]. Interestingly, iron deficiency in various brain regions, including the globus pallidus, caudate nucleus and hippocampus, was characteristic of children with ADHD according to a quantitative susceptibility mapping study conducted by Tang et al [ 61 ]. This, partnered with our study's findings, suggests that iron deficiency in the brain and subsequent dysregulation of the ferroptosis pathway may be associated with ADHD in children.…”

Section: Discussionmentioning

confidence: 99%

Associations Between Blood Leukocyte DNA Methylation and Sustained Attention in Mid-To-Late Childhood

Ehlinger,

Goodrich,

Dolinoy

et al. 2023

Epigenomics

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Aims: To identify associations between DNA methylation (DNAm) across the epigenome and symptoms related to attention-deficit/hyperactivity disorder in a population of Hispanic children. Materials & methods: Among 517 participants in the ELEMENT study aged 9–18 years, we conducted an epigenome-wide association study examining associations between blood leukocyte DNAm and performance on the Conners' continuous performance test (CPT3). Results: DNAm at loci in or near ZNF814, ELF4 and OR6K6 and functional enrichment for gene pathways pertaining to ferroptosis, inflammation, immune response and neurotransmission were significantly related to CPT3 scores. Conclusion: DNAm was associated with CPT3 performance. Further analysis is warranted to understand how these genes and enriched pathways contribute to attention-deficit/hyperactivity disorder.

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Section: Discussionmentioning

confidence: 99%

Associations Between Blood Leukocyte DNA Methylation and Sustained Attention in Mid-To-Late Childhood

Ehlinger,

Goodrich,

Dolinoy

et al. 2023

Epigenomics

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“…We conducted a software-assisted qualitative content analysis on this corpus of documents using Atlas software. We initially took an inductive and interpretative approach: we generated codes with an initial qualitative content analysis of the available texts, built a codebook and subsequently proceeded with a quantitative content analysis counting the frequency of the codes identified in the documents analyzed (Zhang and Wildemuth 2005). 5 Following Zhang and Wildemuth (2005), we used statements corresponding to individual themes as the unit of analysis rather than physical linguistic units (the statements correspond to paragraphs or individual sentences).…”

Section: Methodological Notementioning

confidence: 99%

“…We initially took an inductive and interpretative approach: we generated codes with an initial qualitative content analysis of the available texts, built a codebook and subsequently proceeded with a quantitative content analysis counting the frequency of the codes identified in the documents analyzed (Zhang and Wildemuth 2005). 5 Following Zhang and Wildemuth (2005), we used statements corresponding to individual themes as the unit of analysis rather than physical linguistic units (the statements correspond to paragraphs or individual sentences). In parallel, we also conducted a more in-depth qualitative analysis of the documents to complement the insights produced by the frame analysis, identifying crucial revealing statements in key documents.…”

Section: Methodological Notementioning

confidence: 99%

Modes of Migration City Network Mobilization in the EU and US Multilevel Institutional Systems: The Neglected Role of Politics

Caponio

Pettrachin

2023

International Migration Review

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The existing literature on the multilevel governance of migration in Europe and on migration federalism in the United States tends to assume that the modes of city network (CN) mobilization can be accounted for by different institutional opportunity structures which favor collaborative relations with higher levels of government and civil society in Europe and more contentions interactions in the United States. However, comparative research on how CNs mobilize in different multilevel systems is scarce and largely focuses on official discourse. To fill this gap, this article conducts an inductive policy frame analysis of the discourse and actions of two CNs—the Working Group on Migration and Integration in Europe and Cities for Action in the United States—and examines official documents they released between 2014 and 2019. We find that the actions of CNs are often decoupled from their discourse and are centered on political advocacy, thus challenging the idea that modes of CN mobilization are shaped by institutional opportunity structures. We propose an alternative understanding of CNs as political actors that adapt their discourse and actions to the multilevel political context in which they operate, i.e., to the political leaning of national governments or to the policy issues at stake.

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“…ADHD is a neurodevelopmental disorder characterized by excessive amounts of inattention, carelessness, hyperactivity (which can evolve into inner restlessness in adulthood), and impulsivity that are pervasive, debilitating and otherwise age-inappropriate [137]. Some individuals with ADHD also display difficulty regulating emotions and have executive dysfunction.…”

Section: Brain Iron and Adhdmentioning

confidence: 99%

Brain Iron Homeostasis and Mental Disorders

Wu,

Ren,

Meng

et al. 2023

Antioxidants

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Iron plays an essential role in various physiological processes. A disruption in iron homeostasis can lead to severe consequences, including impaired neurodevelopment, neurodegenerative disorders, stroke, and cancer. Interestingly, the link between mental health disorders and iron homeostasis has not received significant attention. Therefore, our understanding of iron metabolism in the context of psychological diseases is incomplete. In this review, we aim to discuss the pathologies and potential mechanisms that relate to iron homeostasis in associated mental disorders. We propose the hypothesis that maintaining brain iron homeostasis can support neuronal physiological functions by impacting key enzymatic activities during neurotransmission, redox balance, and myelination. In conclusion, our review highlights the importance of investigating the relationship between trace element nutrition and the pathological process of mental disorders, focusing on iron. This nutritional perspective can offer valuable insights for the clinical treatment of mental disorders.

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Quantitative susceptibility mapping shows lower brain iron content in children with attention‐deficit hyperactivity disorder

Cited by 11 publications

References 40 publications

Associations Between Blood Leukocyte DNA Methylation and Sustained Attention in Mid-To-Late Childhood

Associations Between Blood Leukocyte DNA Methylation and Sustained Attention in Mid-To-Late Childhood

Modes of Migration City Network Mobilization in the EU and US Multilevel Institutional Systems: The Neglected Role of Politics

Brain Iron Homeostasis and Mental Disorders

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