2002
DOI: 10.3727/000000002783985314
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Quantitative [18F]Fluorodopa/PET and Histology of Fetal Mesencephalic Dopaminergic Grafts to the Striatum of MPTP-Poisoned Minipigs

Abstract: The functional restoration of the dopamine innervation of striatum in MPTP-poisoned Göttingen minipigs was assessed for 6 months following grafting of fetal pig mesencephalic neurons. Pigs were assigned to a normal control group and a MPTP-poisoned group, members of which received no further treatment, or which received bilateral grafts to the striatum of tissue blocks harvested from E28 fetal pig mesencephalon with and without immunosuppressive treatment after grafting, or with additional co-grafting with imm… Show more

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Cited by 39 publications
(35 citation statements)
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“…The established Göttingen minipig 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) model for PD (Mikkelsen et al 1999) offers several advantages as an experimental animal for brain surgery. The brain is large enough for conventional MRI and PET scanning procedures Cumming et al 2001;Watanabe et al 2001;Dall et al 2002). The minipig is affordable, compared with non-human primates, easily handled and its use potentially avoids some of the ethical considerations concerning the use of primates as laboratory animals (Goodman and Check 2002).…”
Section: Introductionmentioning
confidence: 99%
“…The established Göttingen minipig 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) model for PD (Mikkelsen et al 1999) offers several advantages as an experimental animal for brain surgery. The brain is large enough for conventional MRI and PET scanning procedures Cumming et al 2001;Watanabe et al 2001;Dall et al 2002). The minipig is affordable, compared with non-human primates, easily handled and its use potentially avoids some of the ethical considerations concerning the use of primates as laboratory animals (Goodman and Check 2002).…”
Section: Introductionmentioning
confidence: 99%
“…The estimate in the Østergaard study of the total neuron number in the SN of the domestic pig of 11,400-15,600 is, however, counted using the Abercrombie correction and thus not stereologically based (West et al 1991) and therefore not directly comparable with our cell count of 80,700. As noted earlier by Dall et al 2002, the Østergaard estimate is probably too low when comparing with other species. We speculate that their delineation was different than that of this study.…”
Section: Discussionmentioning
confidence: 88%
“…The Göttingen minipig has gained increased interest during the last decade as a non-primate large experimental animal, also including its use as an animal model in PD (Mikkelsen et al 1999;Danielsen et al 2000;Sørensen et al 2000;Watanabe et al 2001;Dall et al 2002;Bjarkam et al 2004Bjarkam et al , 2005Bjarkam et al , 2008aDalmose et al 2004Dalmose et al , 2005Lind et al 2007;Lindvall and Wahlberg 2008;Jensen et al 2009;Rosendal et al 2009). For further refinement and use of the animal model in PD research, detailed knowledge of the SNc is crucial.…”
Section: Discussionmentioning
confidence: 98%
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