Charles Bonnet Syndrome After Occipital Cortical Resection for Cortical Dysplasia May Be Related to Denervation Supersensitivity

Visual hallucinations: A novel complication after hemispherectomy

“…Leading theories of Charles Bonnet syndrome pathogenesis suggest that deafferentation causes reorganization and hypersensitivity of remaining neurons in the cerebral cortex, generating visual hallucinations from the visual association areas of the brain [8] . In our patients the hallucinations may thus represent a surgically-induced reaction of the occipital cortex to the loss of connectivity from the resected tissue [8] , [9] . Another consideration is that these hallucinations could represent focal occipital lobe seizures either from the residual affected hemisphere with incomplete disconnection (Case 1), or from either occipital lobe particularly the non-resected side (Case 2).…”

Acute Reversible Charles Bonnet Syndrome Following Eye Patch Placement

“…Thus, the visual hallucinations ceased after some time, which may be the result of cortical neuroplasticity and reorganisation. 12 On the other hand, visual impairment in the right eye caused by cataract may be necessary to elicit the hallucinations. Holroyd et al 13 suggested a possible explanation might be that while visual disorder is a predisposing factor for visual hallucinations, the degree of visual loss may not be related to the likelihood of developing CBS.…”

Glutamate excitotoxicity in glaucoma: truth or fiction? By AJ Lotery

“…8 Stimulation of these hypersensitive areas by normal sensory impulses (in this case from the left eye) may trigger visual hallucinations. 7,9,10 However, a minimum amount of sensory input is required in order to trigger the hallucinations. Therefore, when the patient closes both his eyes, normal input is abolished and the hallucinations cease, only to return when he opens his eyes.…”