Quantitative studies on pain threshold after adminisration of various drugs

Analgesic and Antipyretic Drugs

“…In rats, Macht and Macht (147) reported that acetophenetidin at a dose of 30 mg per rat gave effects similar to aspirin and aminopyrine at the same dose in raising the threshold of the squeal response to pain produced by electrical stimulation of the scrotum. D. L. Smith et al ( 193 ) used the tail flick response to a radiant heat stimulus, an adaptation of the Hardy-Wolff method, and found a rise in threshold only with very large doses of 700-900 mg/kg orally of acetophenetidin but no effect with 600 mg/kg subcutaneously.…”

Analgesic Effect of Ergonovine in Male and Female Rats

“…The analgesic effect was tested by the procedure of Macht and Macht (6), modified in our laboratory (2), which consisted of measuring the changes in analgesia with respect to variations in voltage applied to the animals in order to obtain a positive response to pain. The testing procedure consisted of applying square wave monophasic pulses of increasing intensity 50 cycles per sec and 10 m sec duration on the upper line which separates the genital papilla from the abdominal wall.…”