Quantitative Studies of Pulmonary Embolism

Dexter, Lewis; Smith, G.

doi:10.1097/00000441-196406000-00001

Cited by 35 publications

(2 citation statements)

References 3 publications

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“…It has been reported that the responses of the pulmonary circulation differ depending on the size of the emboli. Dalen et al (24) and Dexter (25) reported that pulmonary hypertension can be produced if the emboli are less than 170 µm in diameter and less than 50% of the vascular bed is occluded. Furthermore, an increase in PVR has been observed in patients with embolization of less than 25% of the vascular bed (23).…”

Section: Discussionmentioning

confidence: 99%

The effects of experimental venous carbon dioxide embolization on hemodynamic and respiratory variables

Jersenius

Fors

Rubertsson

et al. 2006

Acta Anaesthesiol Scand

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Section: Discussionmentioning

confidence: 99%

The effects of experimental venous carbon dioxide embolization on hemodynamic and respiratory variables

Jersenius

Fors

Rubertsson

et al. 2006

Acta Anaesthesiol Scand

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“…Most of them , however, mimic only single aspects of ARDS or PAH . The techniques used indude pulmonary microembolization (e.g., g1ass beads (5,22,26,28], fat emboli [4] , oleie acid [3 , 12, 19, 40] , stareh granules [9J, alpha-naphthyl-thiourea (ANTU) [21], blood dots {39] , air [40], barium sulfate [25]) and the intraveflous (thrombin [1 , 27], bacteria [8 , 38], endotoxin [7 , 15], lycopodium spores [13], heroin , alloxan , pyrroles [21]) , intratracheal (ozone [34] , Hel [16] , papain [30]) or intraperitoneal (ammonium sulfate [21]) administration of agents. Most oCten PAH was induced by constriction or OCclflSioli of the pulmonary artery (10,32].…”

Section: Lntroductionmentioning

confidence: 99%

A new experimental model of ARDS and pulmonary hypertension in the dog

Zwißler

Forst²,

Meßmer

1989

Res. Exp. Med.

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Summary. The aim of (his study was to establish a stable and reproducible model of pulmonary artery hypertension with concomitant A RDS-Iike changes o f lung fun ction and lung morphology. In eight anesthetized and ventilated dogs, 0.01 mVkg oleic acid (OA) was given i. v. fo llowed by repetitive injections of 100 J1m glass beads (OB) ioto the right atrium until a mean pulmonary artery pressure of 35~40 mm Hg was reached. Mean fight ventricular (R VP) and pulmonary artery (PA P) pressures, pulmonary vascular resistance (PVR), lung compliance and resistance, Pa0 2, intrapulmonary shunt and colloidosmotic pressure (COP) were c10sely mo nitored for 150min . PAP, RVP, and PVR considerably inereased subsequent 10 O Al GB injection, and slabilized at a high level within 70min , showing only a minimal decrease (PAP, RVP) ur no change (PVR) during the following 8O min . A signifieant decrease of Pa02 and pulmonary eomplianee as weil as an inerease o f resistance and intrapulmonary shunt were found as early as 30 min after the last embolization and they remained unchanged for 120 min . Reduction of COP suggested transcapiUary leakage of maeromoleeules. Histology revealed an interstitial and intraalveolar edema. We conclude that the eombined injeetion of oleie aeid and glass beads provokes microvascul ar Jung injury and results in stable pulmo nary artery hypertensio n wirh concomitant ARDS-like ehanges of lung funetion. Thus, an aeute mode l is provided in the dog allowing for the study of eardiac funetion in ARDS complicated by pulmo nary artery hypertension.

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Pulmonary Embolism Associated with Dialysis Access Procedure

Beathard

2013

Interventional Nephrology

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Quantitative Studies of Pulmonary Embolism

Cited by 35 publications

References 3 publications

The effects of experimental venous carbon dioxide embolization on hemodynamic and respiratory variables

The effects of experimental venous carbon dioxide embolization on hemodynamic and respiratory variables

A new experimental model of ARDS and pulmonary hypertension in the dog

Pulmonary Embolism Associated with Dialysis Access Procedure

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