Quantitative structure-activity relationships of benzoyliminothiadiazoline derivatives as angiotensin II receptor antagonists

On the properties of S⋯O and S⋯π noncovalent interactions: the analysis of geometry, interaction energy and electron density

“…73 The fairly stable SÁ Á ÁO interactions are found in angiotensin II (AII) receptor antagonists. [74][75][76] Such interactions are responsible for both the conformation of these compounds and their activities. 12 The analysis of orbital interaction n Os S * in these compounds may account for the structural features that S prefers to approach O on the orientation of the O lone pair.…”

Synthesis of six new 2‐Aryl‐N‐biphenyl benzimidazoles and crystal structure of methyl 4′ [(2‐p‐Chlorophenyl‐1H‐benzimidazole‐1‐yl)‐methyl]biphenyl‐2‐carboxylate

“…Angiotensin II (AII) is regarded as a major mediator of hypertensive disorders, including essential hypertension [3]. Despite the clinical efficacy of the angiotensin converting enzyme (ACE) inhibitors, these compounds induce side eff e c t s such as dry cough and angioedema, caused by potentiation of bradykinin, substance P and other active peptides, nonpeptide angiotensin II receptor antagonists are of interest [4][5][6]. The antihypertensive activity of nonpeptide angiotensin antagonist has been demonstrated in the clinic [7,8].…”

Synthesis of Six New 2‐Aryl‐N‐biphenyl Benzimidazoles and Crystal Structure of Methyl 4′‐[(2‐p‐Chlorophenyl‐1H‐benzimidazole‐1‐yl)‐methyl] biphenyl‐2‐carboxylate.

“…All new compounds were identified by 1 The renin-angiotensin system (RAS) plays an important role in the control of blood pressure and the regulation of volume and electrolyte homeostasis [1,2]. Despite the clinical efficacy of the angiotensin converting enzyme (ACE) inhibitors, these compounds induce side eff e c t s such as dry cough and angioedema, caused by potentiation of bradykinin, substance P and other active peptides, nonpeptide angiotensin II receptor antagonists are of interest [4][5][6]. Despite the clinical efficacy of the angiotensin converting enzyme (ACE) inhibitors, these compounds induce side eff e c t s such as dry cough and angioedema, caused by potentiation of bradykinin, substance P and other active peptides, nonpeptide angiotensin II receptor antagonists are of interest [4][5][6].…”