Quantitative single-mode fiber based PS-OCT with single input polarization state using Mueller matrix

Ding, Zhenyang; Liang, Chia-Pin; Tang, Qinggong; Chen, Yu

doi:10.1364/boe.6.001828

Cited by 30 publications

(20 citation statements)

References 41 publications

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“…This frequency-domain OCT imaging system utilized a wavelength-swept laser as light source which was centered at 1310 nm with 100 nm bandwidth [54]. The wavelength-swept frequency was 16 kHz with 17 mW output power [55].…”

Section: System Setupmentioning

confidence: 99%

Depth-resolved imaging of colon tumor using optical coherence tomography and fluorescence laminar optical tomography

Tang

Wang

Frank

et al. 2016

Biomed. Opt. Express

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Early detection of neoplastic changes remains a critical challenge in clinical cancer diagnosis and treatment. Many cancers arise from epithelial layers such as those of the gastrointestinal (GI) tract. Current standard endoscopic technology is difficult to detect the subsurface lesions. In this research, we investigated the feasibility of a novel multi-modal optical imaging approach including high-resolution optical coherence tomography (OCT) and high-sensitivity fluorescence laminar optical tomography (FLOT) for structural and molecular imaging. The C57BL/6J-Apc Min /J mice were imaged using OCT and FLOT, and the correlated histopathological diagnosis was obtained. Quantitative structural (scattering coefficient) and molecular (relative enzyme activity) parameters were obtained from OCT and FLOT images for multi-parametric analysis. This multi-modal imaging method has demonstrated the feasibility for more accurate diagnosis with 88.23% (82.35%) for sensitivity (specificity) compared to either modality alone. This study suggested that combining OCT and FLOT is promising for subsurface cancer detection, diagnosis, and characterization. Muthasamy, C. J. Lightdale, N. Santiago, D. K. Pleskow, P. J. Dean, and K. K. Wang, "Endoscopic radiofrequency ablation for Barrett's esophagus: 5-year outcomes from a prospective multicenter trial," Endoscopy 42(10), 781-789 (2010 cancer lesion with swept-source optical coherence tomography," J.

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Section: System Setupmentioning

confidence: 99%

Depth-resolved imaging of colon tumor using optical coherence tomography and fluorescence laminar optical tomography

Tang

Wang

Frank

et al. 2016

Biomed. Opt. Express

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“…6 However, external factors (such as temperature and mechanical stress) affect the birefringence of single-mode fibers (SMFs) used in OCT systems, inducing disturbances 7 to the measured polarization.…”

Section: Introductionmentioning

confidence: 99%

Snapshot polarization-sensitive plug-in optical module for a Fourier-domain optical coherence tomography system

Marques¹,

Rivet²,

Bradu³

et al. 2018

Optical Coherence Tomography and Coherence Domain Optical Methods in Biomedicine XXII

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In this communication, we present a proof-of-concept polarization-sensitive Optical Coherence Tomography (PS-OCT) which can be used to characterize the retardance and the axis orientation of a linear birefringent sample. This module configuration is an improvement from our previous work 1, 2 since it encodes the two polarization channels on the optical path difference, effectively carrying out the polarization measurements simultaneously (snapshot measurement), whilst retaining all the advantages (namely the insensitivity to environmental parameters when using SM fibers) of these two previous configurations. Further progress consists in employing Master Slave OCT technology, 3 which is used to automatically compensate for the dispersion mismatch introduced by the elements in the module. This is essential given the encoding of the polarization states on two different optical path lengths, each of them having dissimilar dispersive properties. By utilizing this method instead of the commonly used re-linearization and numerical dispersion compensation methods an improvement in terms of the calculation time required can be achieved.

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“…4 However, external factors (such as temperature and mechanical stress) affect the birefringence of single-mode fibers (SMFs) used in OCT systems, inducing disturbances 5 to the measured polarization.…”

Section: Introductionmentioning

confidence: 99%

Polarization-sensitive plug-in optical module for a Fourier-domain optical coherence tomography system

Marques

Rivet²,

Bradu

et al. 2017

Optical Coherence Tomography and Coherence Domain Optical Methods in Biomedicine XXI

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In this manuscript we communicate a theoretical study on a plug-in optical module to be used within a Fourier-domain optical coherence tomography system (FD-OCT). The module can be inserted between the object under investigation and any single-mode fiber based FD-OCT imaging instrument, enabling the latter to carry out polarization measurements on the former. Similarly to our previous communication 1 this is an active module which requires two sequential steps to perform a polarization measurement. Alternating between the two steps is achieved by changing the value of the retardance produced by two electro-optic polarization modulators, which together behave as a polarization state rotator. By combining the rotation of the polarization state with a projection against a linear polarizer it is possible to ensure that the polarization measurements are free from any undesirable polarization effects caused by the birefringence in the collecting fiber and diattenuation in the fiber-based couplers employed in the system. Unlike our previous work, though, this module adopts an in-line configuration, employing a Faraday rotator to ensure a non-reciprocal behavior between the forward and backward propagation paths.The module design also allows higher imaging rates due to the use of fast electro-optic modulators. Simulations have been carried out accounting for the chromatic effects of the polarization components, in order to evaluate the theoretical performance of the module.

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Quantitative single-mode fiber based PS-OCT with single input polarization state using Mueller matrix

Cited by 30 publications

References 41 publications

Depth-resolved imaging of colon tumor using optical coherence tomography and fluorescence laminar optical tomography

Depth-resolved imaging of colon tumor using optical coherence tomography and fluorescence laminar optical tomography

Snapshot polarization-sensitive plug-in optical module for a Fourier-domain optical coherence tomography system

Polarization-sensitive plug-in optical module for a Fourier-domain optical coherence tomography system

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