Quantitative risk of positive family history in developing colorectal cancer: A meta-analysis

Abstract

BACKGROUND Positive family history is a risk factor for development of colorectal cancer. Despite numerous studies on the topic, the absolute risk in patients with a positive family history remains unclear and therefore studies are lacking to validate non-invasive screening methods in individuals with positive family history. AIM To quantify the risk of colorectal cancer in individuals with a positive family history. METHODS A comprehensive electronic literature search was performed using PubMed from January 1955 until November 2017, EMBASE from 1947 until 2018, and Cochrane Library without date restrictions. Two independent reviewers conducted study selection, data extraction and quality assessment. A meta-analysis of Mantel-Haenzel relative risks was performed using the random effects model. Newcastle-Ottawa scale was used to score the quality of selected papers. Funnel plot and Egger’s regression test was performed to detect publication bias. Subgroup analysis was performed comparing Asian and non-Asian studies. Sensitivity analyses were performed to rule out the effect of the timing of the study, overall quality, the main outcome and the effect of each individual study in overall result. RESULTS Forty-six out of 3390 studies, including 906981 patients were included in the final analysis. 41 of the included studies were case-control and 5 were cohort. A positive family history of colorectal cancer in first-degree relatives was associated with significantly increased risk of colorectal cancer with a relative risk of 1.87 (95%CI: 1.68-2.09; P < 0.00001). Cochrane Q test was significant ( P < 0.00001, I 2 = 90%). Egger’s regression test showed asymmetry in the funnel plot and therefore the Trim and Fill method was used which confirmed the validity of the results. There was no difference between Asian versus non-Asian studies. Results remained robust in sensitivity analyses. CONCLUSION Individuals with a positive family history of colorectal cancer are 1.87 times more likely to develop colorectal cancer. Screening guidelines should pay specific attention to individuals with positive family history and further studies need to be done on validating current screening methods or developing new modalities in this high-risk population.

Association of Family History and Life Habits in the Development of Colorectal Cancer: A Matched Case-Control Study in Mexico

“…Previous studies recognize family aggregation of cancer and CRC as an im portant factor. A recent meta-analysis suggested the risk association between family his tory of CRC in first degree relatives with a relative risk of 1.87 (p < 0.001) [18]. (A) Models unadjusted and (B) adjusted for the following variables: area of origin, marital status, sedentary lifestyle, consumption of fruits, beef, pork, and fried foods typical of the region by the "forward: conditional" method.…”

“…Previous studies recognize family aggregation of cancer and CRC as an important factor. A recent meta-analysis suggested the risk association between family history of CRC in first degree relatives with a relative risk of 1.87 (p < 0.001) [18].…”

Perceptions and motivations for healthy lifestyles among first-degree relatives of colorectal cancer patients: A qualitative study

“…In 2030, there will be 2.2 million new cases and 1.1 deaths of colorectal cancer globally, with a 60% increase in the global economic burden [1]. Especially, the risk of CRC increases with the number of degree relatives and at 1.87 is substantially higher among rst-degree relatives (FDRs) than in the general population [2]. The probability of getting colorectal cancer increases by up to ve times in individuals with two or more FDRs with CRC history at the same time [3].…”

“…Indirect cancer experience or family history is strongly correlated with developing awareness [15]. However, the current state of behaviour towards a healthy lifestyle for CRC is not favourable [2,7,8], with issues such as poor diet (for example, excessive intake of fat and red meat, inadequate fruit, vegetables, and dietary bre), lack of physical activity, obesity, excessive alcohol consumption, and smoking. Several studies have proven that in addition to dietary factors, they are not well-informed about the relationship between other lifestyle factors and CRC [11,15].…”

Clinical and Morphological Manifestations of Gastritis and Serum Cytokine Levels in Schoolchildren with Familial History of Gastric Cancer

“…Неблагоприятным периодом у детей, характеризующимся ростом заболеваний желудка, считается школьный [5]. Негативную роль играет семейная предрасположенность [1,6,7], особенно к таким заболеваниям, как рак желудка [8][9][10][11]. Генетической основой служит специфика нейрогуморальной регуляции и морфофункциональные особенности желудка [12].…”