Quantitative Relationship between Structural Extent of Centrilobular Emphysema and Postmortem Volume and Flow Characteristics of Lungs

Pratt, Philip C.; Jutabha, O; Klugh, George A.

doi:10.1159/000192402

Cited by 10 publications

(1 citation statement)

References 2 publications

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“…* * * * * * * * * * Seventeenth Industrial Hearing Conservation Institute, July [14][15][16]1980, atthe University of Maine, Orono, is concerned with responsibilities of occupational health nurses and others in maintaining effective hearing conservation programs. For descriptive brochure and application, write: UMO Coordinator, 1721 Pine Street, Philadel phia, Pennsylvania 19102.…”

Section: Discussionmentioning

confidence: 99%

Epidemiology of Pulmonary Lesions in Nontextile and Cotton Textile Workers: A Retrospective Autopsy Analysis

Pratt

Vollmer

Miller

1980

Archives of Environmental Health: An International Journal

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A collection of 565 unselected inflation-fixed lungs was divided into three groups: (1) normal (209 lungs); (2) centrilobular emphysema (231) lungs); and (3) "other" (125 lungs), the last including examples of fibrosis, tuberculosis, cancer, and other forms of emphysema. Clinical hospital records were reviewed to ascertain smoking history [no smoking (105 lungs); greater than 0.5 pack cigarettes per day (427 lungs); or pipe/cigar (33 lungs)] and occupation [nontextile (521 lungs), or textile (44 lungs)]. Lungs were subjected to morphometric determination of the extent of centrilobular emphysema, mucus gland hyperplasia in large bronchi, and goblet cell metaplasia in bronchioles. Extent of tissue pigmentation in normal lungs was also measured. Associations between morphologic data and background factors were examined by covariance analysis. As in many previous studies, data show highly significant cigarette smoking effects on all factors measured. Significant pipe smoker effects were also found, and when the cigarette group was excluded, a significant association was found between cotton dust exposure and both mucus gland hyperplasia and goblet cell metaplasia, but not emphysema. The results suggest that centrilobular emphysema is not associated occupationally in the textile industry, although bronchitis and bronchiolitis probably are. If byssinotic symptoms and physiologic impairment are as prevalent as some have reported, they must be primarily related to airway lesions. It might follow that they should be reversible. Textile workers with irreversible impairment and morphologic emphysema who are also smokers probably have little or no justification for attributing this to their occupation.

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Section: Discussionmentioning

confidence: 99%

Epidemiology of Pulmonary Lesions in Nontextile and Cotton Textile Workers: A Retrospective Autopsy Analysis

Pratt

Vollmer

Miller

1980

Archives of Environmental Health: An International Journal

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Pulmonary Emphysema: Pathology and Pathogenesis

Tomashefski

Pratt

1967

Medical Clinics of North America

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Maximum volumes in excised human lungs: effects of age, emphysema, and formalin inflation.

Berend¹,

Skoog²,

Waszkiewicz³

et al. 1980

Thorax

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The volume of air at a transpulmonary pressure (PL) In infants and children, the ratio of VL minus lung weight to V25 averaged 1 -08 with a range of 0 58 to 1 84. The larger the lungs, the smaller the ratio, suggesting that fixation played a role in producing the small VL. In the emphysematous lungs, a significant correlation between the degree of emphysema and V25 was found. However, a statistically significant increase in V25 only occurred when the emphysema grade was greater than 5.Many studies have demonstrated a relationship between total lung capacity (TLC) and height, age and height, or height and weight in normal subjects.'-6 Since TLC is governed by the interaction of lung elastic properties, chest wall mechanics, and inspiratory muscle strength, it is of interest to document maximum lung volumes in excised lungs in which only lung elastic properties are a factor.In patients with emphysema, TLC has been shown to be increased in some studies,7-9 but not in others,'0-'4 and there is uncertainty as to what degree of emphysema is necessary to produce such a change.In morphometric studies of lung structure, it is common practice to inflate the lungs with a liquid fixative at a constant transpulmonary pressure (PL) of 25 cmH2O (2)(3)(4)(5)

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Quantitative Relationship between Structural Extent of Centrilobular Emphysema and Postmortem Volume and Flow Characteristics of Lungs

Cited by 10 publications

References 2 publications

Epidemiology of Pulmonary Lesions in Nontextile and Cotton Textile Workers: A Retrospective Autopsy Analysis

Epidemiology of Pulmonary Lesions in Nontextile and Cotton Textile Workers: A Retrospective Autopsy Analysis

Pulmonary Emphysema: Pathology and Pathogenesis

Maximum volumes in excised human lungs: effects of age, emphysema, and formalin inflation.

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