Epidemiology of Pulmonary Lesions in Nontextile and Cotton Textile Workers: A Retrospective Autopsy Analysis

Pratt, Philip C.; Vollmer, Robin T.; Miller, James A.

doi:10.1080/00039896.1980.10667480

Cited by 58 publications

(21 citation statements)

References 8 publications

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“…Cotton dust: Whether cotton dust exposure has chronic effects on the lungs capable of disabling those affected has been the subject of debate for many years and is still not resolved. Neither pathology studies (30,31) nor mortality studi-es (32) concerning cotton dust showed convincing evidence of a relationship between cotton dust exposure and emphysema.…”

Section: Organic Dustsmentioning

confidence: 99%

Occupational Exposures and Chronic Airflow Limitation

Dimich‐Ward¹,

Kennedy²,

Chan‐Yeung³

1996

Canadian Respiratory Journal

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S tudies have shown that the diseases of dusty occupations, in particular the pneumoconioses, are on the decline in developed countries. In contrast, mortality rates due to the chronic nonmalignant lung diseases including those characterized by airflow obstruction are increasing (1) and these diseases are responsible for high rates of morbidity and extended periods of disablement. It is now generally accepted that occupational exposure to organic dusts such as grain and cotton The recent literature was reviewed to evaluate whether chronic airflow limitation is associated with occupational exposures to dusts. Only those studies that controlled for the effects of smoking were included. There is compelling evidence that exposure to inorganic dusts, such as from coal and hardrock mining or asbestos, are associated with the development of chronic airflow limitation, independently of pneumoconiosis. Nonsmoking gold miners are particularly at high risk of airflow obstruction and emphysema. Findings from studies of organic dusts, such as exposures to wood, cotton, grain or other agricultural dusts, or to mixed dust exposures, were less consistent but tended to show positive dose-response associations. In the majority of studies, no statistical interaction was shown between dust exposures and smoking; however, the effects of the dust exposures were often more pronounced. An occupational history should be considered, in addition to a smoking history, as an integral part of an investigation of chronic airflow limitation in a patient. Key Words: Chronic airflow limitation, FEV 1 , Occupational exposures, SmokingLes expositions professionnelles et l'obstruction respiratoire chronique RÉSUMÉ : On a passé en revue les études récentes pour éval-uer si l'obstruction respiratoire chronique a un rapport avec les expositions professionnelles aux poussières. Seules les études avec groupe témoin pour les effets du tabagisme ont été retenues. On peut conclure que les expositions aux poussières inorganiques comme celles provenant du charbon et des roches ou de l'amiante est associée à l'obstruction respiratoire chronique, indépendamment d'une pneumoconiose. Les nonfumeurs qui travaillent dans les mines d'or sont particulière-ment exposés au développement d'une obstruction respiratoire et d'un emphysème. Les résultats des études sur les poussières organiques, telles que les expositions aux poussières de bois, de coton, de grain ou d'autres poussières agricoles, ou les expositions à plusieurs types de poussières étaient moins constants mais tendaient à démontrer une association dose-réponse positive. Dans la plupart des études, aucun lien statistique n'a été démontré entre les expositions aux poussières et le tabagisme; toutefois, les effets des expositions aux poussières étaient souvent plus prononcés. Par conséquent, les antécédents professionnels tout comme les antécédents de consommation de tabac devraient faire partie intégrante de l'anamnèse chez un patient présentant une obstruction respiratoire chronique.

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Section: Organic Dustsmentioning

confidence: 99%

Occupational Exposures and Chronic Airflow Limitation

Dimich‐Ward¹,

Kennedy²,

Chan‐Yeung³

1996

Canadian Respiratory Journal

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“…It also seems that T lym phocytes are involved in the process of goblet cell metaplasia and that lymphokines stimulate goblet cell mucus production [27,28]. Both goblet cell metapla sia and mucus gland hypertrophy are associated with chronic byssinosis [29]. The finding of peribronchial lymphocyte infiltration in the lungs of experimental animals chronically exposed to cotton dust [30] sup ports the notion of lymphocyte involvement in the disease process.…”

Section: Discussionmentioning

confidence: 69%

Cotton Bract Tannin: A Novel Human T-Lymphocyte Mitogen and a Possible Causative Agent of Byssinosis

Vuk-Pavlović

Russell

Rohrbach

1988

Int Arch Allergy Immunol

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Cotton bract tannin, a major organic component of cotton dust, was tested for mitogenic activity upon human T lymphocytes. Tannin caused polyclonal activation of human T lymphocytes in vitro. The pattern of T-cell response to tannin was similar to the pattern seen in lymphocytes stimulated with the well-known plant lectin T-cell mitogens, PHA and ConA. The response to tannin was shown to be dependent upon tannin dose and presence of monocytes. The maximum response occurred after 3–4 days in culture with the magnitude comparable to the one achieved by ConA. Lipopolysaccharide from Enterobacter agglomerans, a major contaminant of cotton dust, was shown not to be a mediator of tannin mitogenicity in vitro. A role for tannin as a polyclonal cell activator and, therefore, a possible etiologic agent of byssinosis is suggested by these observations.

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“…Pratt et al 4 recently reviewed the autopsy prevalence of emphysema in 565 unselected autopsies (all male subjects, including 44 textile workers) for whom smoking histories were available. Their morphologic findings indicated a significant association between cotton dust exposure and both mucous gland hyperplasia in large airways and goblet cell metaplasia in small airways, but no association with emphysema.…”

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confidence: 99%

Emphysema and Other Chronic Lung Disease in Textile Workers: An 18-Year Autopsy Study

Moran

1983

Archives of Environmental Health: An International Journal

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Review of 2895 consecutive autopsies from 1962 to 1980 inclusive showed no significant differences in the prevalence of emphysema or other chronic lung disease between 282 active and retired employees of a cotton textile mill and the nontextile population. There was no statistical evidence that exposure to cotton dust, even after many years, produced emphysema, interstitial fibrosis, or cor pulmonale. The prevalence of emphysema in the series was highest in white males (22.0%), followed closely by black males (18.3%). In white females it was 7.5%, in black females, 5.5%. The prevalence in subjects under age 50 yr was 4.5%; in the age group 60-64 yr, 14.6%; and in subjects 65 yr of age and older, 21.9%. A significant increase in the prevalence of emphysema occurred between the 1962 to 1969 period and the 1970 to 1980 period.

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Epidemiology of Pulmonary Lesions in Nontextile and Cotton Textile Workers: A Retrospective Autopsy Analysis

Cited by 58 publications

References 8 publications

Occupational Exposures and Chronic Airflow Limitation

Occupational Exposures and Chronic Airflow Limitation

Cotton Bract Tannin: A Novel Human T-Lymphocyte Mitogen and a Possible Causative Agent of Byssinosis

Emphysema and Other Chronic Lung Disease in Textile Workers: An 18-Year Autopsy Study

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