Abstract:Diethylstilbestrol (DES) has a direct cellular mechanism inhibition on prostate cancer. Its action is independent from the oestrogen receptors and is preserved after a first-line hormonal therapy. We aimed to identify proteins involved in the direct cellular inhibition effects of DES on prostate cancer. We used a clonogenic assay to establish the median lethal concentration of DES on 22RV1 cells. 22RV1 cells were exposed to standard and DES-enriched medium. After extraction, protein expression levels were obta… Show more
“…A proteomic profile for each sample has been separately acquired by iTRAQ labeling using a previously developed method [11]. This allowed the identification of dysregulated proteins according to the SSIGN prognosis score.…”
“…A proteomic profile for each sample has been separately acquired by iTRAQ labeling using a previously developed method [11]. This allowed the identification of dysregulated proteins according to the SSIGN prognosis score.…”
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