Identification and validation of TGFBI as a promising prognosis marker of clear cell renal cell carcinoma

Lebdai, Souhil; Verhoest, G.; Parikh, Hemang; Jacquet, Solène Florence; Bensalah, Karim; Chautard, Denis; Leclercq, Nathalie; Azzouzi, Abdel Rahmène; Bigot, Pierre

doi:10.1016/j.urolonc.2014.06.005

Cited by 34 publications

(30 citation statements)

References 25 publications

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“…TGFBI has been observed to serve contradictory functions in tumorigenesis . Although TGFBI was reported to function as a tumour suppressor in leukaemia and ovarian, prostate, and lung carcinomas, the tumour‐promoting role of TGFBI was indicated in renal cell carcinoma, pancreatic carcinoma, oral and oesophageal squamous cell carcinoma, and colon carcinoma . Furthermore, Han et al reported a role for TGFBI in tumorigenesis of the gastrointestinal tract by demonstrating that TGFBI overexpression increased the incidence of spontaneous tumours including gastric adenocarcinoma in transgenic mice.…”

Section: Discussionmentioning

confidence: 99%

“…Conversely, TGFBI was also known to exert tumour‐promoter functions in various cancers. TGFBI upregulation was reported in pancreatic carcinoma and oral squamous cell carcinoma, whereas in renal cell carcinoma, TGFBI expression was revealed as a promising prognostic marker . Regarding GC, the transgenic mice overexpressing TGFBI developed spontaneous gastric adenocarcinoma at a high rate than wild‐type mice; however, few studies investigated the role of TGFBI in human GC specimens in detail.…”

Section: Introductionmentioning

confidence: 99%

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High stromal transforming growth factor β–induced expression is a novel marker of progression and poor prognosis in gastric cancer

Suzuki

Yokobori

Gombodorj

et al. 2018

Journal of Surgical Oncology

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

High stromal transforming growth factor β–induced expression is a novel marker of progression and poor prognosis in gastric cancer

Suzuki

Yokobori

Gombodorj

et al. 2018

Journal of Surgical Oncology

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“…The Sonic hedgehog signaling pathway (7) and MYC pathway (8) are also activated in KIRC and serve a role in tumor growth. Furthermore, numerous biomarkers have been identified, including cluster of differentiation 70 (8), succinate dehydrogenase B (8) and transforming growth factor beta 1 (9). Nevertheless, further studies are required to identify novel prognostic genes and provide potential therapeutic targets.…”

Section: Introductionmentioning

confidence: 99%

Identification of prognostic genes in kidney renal clear cell carcinoma by RNA-seq data analysis

et al. 2017

Molecular Medicine Reports

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The present study aimed to analyze RNA-seq data of kidney renal clear cell carcinoma (KIRC) to identify prognostic genes. RNA-seq data were downloaded from The Cancer Genome Atlas. Feature genes with a coefficient of variation (CV) >0.5 were selected using the genefilter package in R. Gene co-expression networks were constructed with the WGCNA package. Cox regression analysis was performed using the survive package. Furthermore, a functional enrichment analysis was conducted using Database for Annotation, Visualization and Integrated Discovery tools. A total of 533 KIRC samples were collected, from which 6,758 feature genes with a CV >0.5 were obtained for further analysis. The KIRC samples were divided into two sets: The training set (n=319 samples) and the validation set (n=214 samples). Subsequently, gene co-expression networks were constructed for the two sets. A total of 12 modules were identified, and the green module was significantly associated with survival time. Genes from the green module were revealed to be implicated in the cell cycle and p53 signaling pathway. In addition, a total of 11 hub genes were revealed, and 10 of them (CCNA2, CDC20, CDCA8, GTSE1, KIF23, KIF2C, KIF4A, MELK, TOP2A and TPX2) were validated as possessing prognostic value, as determined by conducting a survival analysis on another gene expression dataset. In conclusion, a total of 10 prognostic genes were identified in KIRC. These findings may help to advance the understanding of this disease, and may also provide potential biomarkers for therapeutic development.

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“…The results of the meta-analysis conducted by Yang demonstrated that the high expression of TGF-β was strongly associated with the 3-year survival rate in patients with glioma [30]. Similar results were also found in patients with gastric cancer [31], hepatocellular carcinoma [32], renal cancer [33], breast cancer [34], and oesophageal cancer [35]. …”

Section: Discussionmentioning

confidence: 70%

Prognostic value of transforming growth factor-beta in patients with colorectal cancer who undergo surgery: a meta-analysis

Chen

Zhu

et al. 2017

BMC Cancer

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BackgroundTransforming growth factor-beta (TGF-β) is associated with a higher incidence of distant metastasis and decreased survival. Whether TGF-β can be used as a prognostic indicator of colorectal cancer (CRC) remains controversial.MethodsThe Medline, EMBASE and Cochrane databases were searched from their inception to March 2016. The studies that focused on TGF-β as a prognostic factor in patients with CRC were included in this analysis. Overall survival (OS) and disease-free survival (DFS) were analysed separately. A meta-analysis was performed, and hazard ratios (HR) with 95% confidence intervals (CI) were calculated.ResultsTwelve studies were included in the analysis, of which 8 were used for OS and 7 for DFS. In all, 1622 patients with CRC undergoing surgery were included. Combined HRs suggested that high expression of TGF-β had a favourable impact on OS (HR = 1.68, 95% CI: 1.10–2.59) and DFS (HR = 1.11, 95% CI: 1.03–1.19) in CRC patients. For OS, the combined HRs of Asian studies and Western studies were 1.50 (95% CI: 0.61–3.68) and 1.80 (95% CI: 1.33–2.45), respectively. For DFS, the combined HRs of Asian studies and Western studies were 1.42 (95% CI: 0.61–3.31) and 1.11 (95% CI: 1.03–1.20), respectively.ConclusionsThis meta-analysis demonstrates that TGF-β can be used as a prognostic biomarker for CRC patients undergoing surgery, especially for CRC patients from Western countries.Electronic supplementary materialThe online version of this article (doi:10.1186/s12885-017-3215-7) contains supplementary material, which is available to authorized users.

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Identification and validation of TGFBI as a promising prognosis marker of clear cell renal cell carcinoma

Cited by 34 publications

References 25 publications

High stromal transforming growth factor β–induced expression is a novel marker of progression and poor prognosis in gastric cancer

High stromal transforming growth factor β–induced expression is a novel marker of progression and poor prognosis in gastric cancer

Identification of prognostic genes in kidney renal clear cell carcinoma by RNA-seq data analysis

Prognostic value of transforming growth factor-beta in patients with colorectal cancer who undergo surgery: a meta-analysis

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