Quantitative pathology of the intraepithelial laryngeal neoplasia

Abstract

A clinical-histologic and morphometric study on 32 patients with precancerous laryngeal lesions was carried out. Two biopsies taken at different times were studied, and the cases in which carcinoma developed were compared with those cases in which it did not. The only clinical-histologic variable with prognostic value, related with evolution to carcinoma, was severe dysplasia. The Malignancy Grading System, which grouped together 13 clinical-histologic variables, had both high sensitivity and high specificity. On the other hand, quantitative microscopy was a more sensitive and objective method. Through the relationship between the parameters of orientation/nuclearity and Histometric Progression Index, we could separate those cases in which invasive carcinoma developed from those cases in which it did not with a sensitivity of 100% and a specificity of 82%.

Phonosurgical resection using submucosal infusion technique for precancerous laryngeal leukoplakia

“…Several studies have reported widely varying malignant transformation rates (MTR) of between 6% and 74% . However, it is extremely difficult to precisely analyze these data from several studies, because the severity grading of the atypia is not standardized, and different approaches for diagnosis are reported in the literature.…”

Diagnostic Variability of Laryngeal Premalignant Lesions: Histological Evaluation and Carcinoma Transformation

“…Carcinoma transformation rate of laryngeal dysplasia varies largely from 2% to 74% among investigated cases. 8,9 A recent meta-analysis has shown that laryngeal dysplasia lesions has a 14% overall transformation rate (95% confidence interval [CI], [8][9][10][11][12][13][14][15][16][17][18][19][20][21][22], and the malignant transformation risk is higher with increased severity of dysplasia grade. 10 Laryngeal dysplasia remains one of the most controversial topics in laryngeal pathology.…”

Biomarkers in laryngeal dysplasia: A systematic review

“…Laryngeal dysplasia is a premalignant condition reported to affect between 2 and 10 per 100,000 of the population 1. Studies vary widely in their reported malignant transformation rates from 2% to 74% of cases 2, 3. A recent meta‐analysis has shown an overall transformation rate of 14% (95% confidence interval [CI] 8% to 22%) for laryngeal dysplastic lesions 4…”