Biomarkers in laryngeal dysplasia: A systematic review

Nankivell, Paul; Weller, Matthew; McConkey, Christopher C.; Paleri, Vinidh; Mehanna, Hisham

doi:10.1002/hed.21592

Cited by 28 publications

(25 citation statements)

References 40 publications

(95 reference statements)

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“…The concept of high‐grade SILs eliminates the problem of moderate dysplasia, which is a major source of interobserver variation in the dysplasia system. A similar improvement in interobserver agreement has been provided in the grading of oral dysplasia, through the introduction of a binary system …”

Section: Discussionmentioning

confidence: 81%

Evaluation of a new grading system for laryngeal squamous intraepithelial lesions—a proposed unified classification

et al. 2014

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Section: Discussionmentioning

confidence: 81%

Evaluation of a new grading system for laryngeal squamous intraepithelial lesions—a proposed unified classification

et al. 2014

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“…However, the five studies that analyzed this marker used different cut-offs to determine the percentage of p53 positive staining, which emphasizes the need for cautionary remarks on the value of immunohistochemistry as made above. Although a sensitivity analysis was performed for each of the cut-offs used, p53 was not found to significantly predict progression [45]. Only two of the seven studies included in our review that analyzed p53 showed a prognostic significance for this marker.…”

Section: Discussionmentioning

confidence: 85%

“…This problem has also been highlighted in another recent systematic review on this topic [45]. In that review, the authors only included 9 articles.…”

Section: Discussionmentioning

confidence: 94%

Biomarkers predicting malignant progression of laryngeal epithelial precursor lesions: a systematic review

Rodrigo

Suárez

Takes

et al. 2011

Eur Arch Otorhinolaryngol

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Some laryngeal epithelial precursor lesions progress to invasive carcinoma and others do not. Routine light microscopic classification has limited value in predicting the evolution of these lesions. This article reviews the experience to date with the use of molecular markers for the prognostic evaluation of laryngeal epithelial precursor lesions. We conducted a thorough review of the published literature to identify those studies using biomarkers to predict malignant progression of laryngeal epithelial precursor lesions. Of the 336 studies identified in this systematic search, 15 met the inclusion criteria and form the basis of this review. Limited studies suggest that certain biomarkers are potentially reliable predictors of malignant progression including various regulators of cell adhesion and invasion (e.g. FAK, cortactin, osteopontin, and CD44v6) and proliferation-associated markers such as TGF-βRII and Kv3.4. The predictive value of these markers, however, has yet to be confirmed in large-scale prospective studies. Although the cell cycle-related proteins are the most frequently studied markers, none have been consistently reliable across multiple studies. The absence of standardization in methodologies, test interpretation, and other parameters may contribute to study inconsistencies. Various biomarkers have proved to have potential prognostic value and could be clinically relevant. The utility and prognostic power of these biomarkers should be confirmed in large, well-designed, standardized prospective studies.

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“…None of these were statistically significant either alone, or when pooled in a metaanalysis, with a risk ratio of 0.96 (95% CI=0.65, 1.42; P= 0.84). This lack of prognostic ability for p53 has also been demonstrated in laryngeal dysplasia [52]. In the same review, cathepsin L mRNA, MMP1/2 mRNA, p73, and LOH 8p all did not show a statistically significant predictive ability.…”

Section: Biomarkers With Potential Predictive/prognostic Abilitymentioning

confidence: 85%

Oral Dysplasia: Biomarkers, Treatment, and Follow-up

Nankivell

Mehanna

2011

Curr Oncol Rep

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Dysplasia affecting the oral mucosa has a malignant potential. The options for treatment of oral dysplasia are limited. Surgery remains the mainstay of management, with no strong evidence for medical treatments currently available. Histological grading alone does not accurately predict which dysplastic lesions will progress to cancer, which poses the clinician with difficult decisions regarding the most appropriate treatment and may lead to some patients being overtreated, with potentially unnecessary morbidity. The use of biomarkers may help to improve prediction of which cases are likely to transform. The efficacy of individual markers for prediction will be discussed in this paper. There is also a lack of consensus on the optimal frequency and duration of follow-up for patients with oral dysplasia.

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Biomarkers in laryngeal dysplasia: A systematic review

Cited by 28 publications

References 40 publications

Evaluation of a new grading system for laryngeal squamous intraepithelial lesions—a proposed unified classification

Evaluation of a new grading system for laryngeal squamous intraepithelial lesions—a proposed unified classification

Biomarkers predicting malignant progression of laryngeal epithelial precursor lesions: a systematic review

Oral Dysplasia: Biomarkers, Treatment, and Follow-up

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