Quantitative OCT Angiography of the Retinal Microvasculature and the Choriocapillaris in Myopic Eyes

Al-Sheikh, Mayss; Phasukkijwatana, Nopasak; Dolz-Marco, Rosa; Rahimi, Masoud; Iafe, Nicholas A.; Freund, K. Bailey; Sadda, Srinivas R.; Sarraf, David

doi:10.1167/iovs.16-21289

Cited by 259 publications

(202 citation statements)

References 41 publications

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“…In the OCTA CC scans, dark regions referred to as flow voids may alternate with granular bright areas, and this pattern may systematically change with age or myopia. 12,13 The latter may represent CC flow, while the former more may be secondary to CC dropout. 14 It is important to note that the detectable flow range of OCTA is limited, and flows below the decorrelation threshold are indistinguishable from background noise and are thus undetectable.…”

Section: Resultsmentioning

confidence: 99%

Alterations in the Choriocapillaris in Intermediate Age-Related Macular Degeneration

Borrelli

Uji

Sarraf

et al. 2017

Invest. Ophthalmol. Vis. Sci.

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134

113

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Section: Resultsmentioning

confidence: 99%

Alterations in the Choriocapillaris in Intermediate Age-Related Macular Degeneration

Borrelli

Uji

Sarraf

et al. 2017

Invest. Ophthalmol. Vis. Sci.

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134

113

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“…In a study by Wang et al [38] including 105 healthy participants with an axial length between 21.44 and 28.16 mm, CC vessel density was not significantly correlated with axial length. In another study by Al-Sheikh et al [39] including 28 patients with an axial length >26.5 mm, OCTA demonstrated an increase in the total and average area of flow voids in the CC. Whether the reduced CC perfusion may be the result of a stretching of the CC occurring with increased axial enlargement or whether this must rather be regarded as a pathologic change in terms of a choroidal loss needs to be investigated in future studies.…”

Section: Octa In Healthy Subjectsmentioning

confidence: 85%

Optical Coherence Tomography Angiography Offers New Insights into Choriocapillaris Perfusion

Lauermann¹,

Eter²,

Alten³

2018

Ophthalmologica

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The choriocapillaris (CC) represents a fundamentally important vascular layer that is subject to physiologic changes with increasing age and that is also associated with a wide range of chorioretinal diseases. So far, information on blood flow in this specific layer has remained limited. With the advent of optical coherence tomography angiography (OCTA), new perspectives and possibilities of CC imaging have begun to evolve. This article shall review the opportunities and challenges of applying OCTA technology to the CC layer and summarize the current clinical efforts in OCTA CC imaging exemplarily in dry age-related macular degeneration and central serous chorioretinopathy.

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“…In addition, outcome parameters for OCTA have not clearly been defined. Some authors used analysis of flow voids or signal voids in the choriocapillaris to quantify the area that is covered by the microvasculature,89 90 but data in patients with myopia are limited 91. Different authors used, however, different image analysis approaches to quantify signal voids and no common protocol is currently available.…”

Section: Introductionmentioning

confidence: 99%

Imaging in myopia: potential biomarkers, current challenges and future developments

et al. 2019

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Myopia is rapidly increasing in Asia and around the world, while it is recognised that complications from high myopia may cause significant visual impairment. Thus, imaging the myopic eye is important for the diagnosis of sight-threatening complications, monitoring of disease progression and evaluation of treatments. For example, recent advances in high-resolution imaging using optical coherence tomography may delineate early myopic macula pathology, optical coherence tomography angiography may aid early choroidal neovascularisation detection, while multimodal imaging is important for monitoring treatment response. However, imaging the eye with high myopia accurately has its challenges and limitations, which are important for clinicians to understand in order to choose the best imaging modality and interpret the images accurately. In this review, we present the current imaging modalities available from the anterior to posterior segment of the myopic eye, including the optic nerve. We summarise the clinical indications, image interpretation and future developments that may overcome current technological limitations. We also discuss potential biomarkers for myopic progression or development of complications, including basement membrane defects, and choroidal atrophy or choroidal thickness measurements. Finally, we present future developments in the field of myopia imaging, such as photoacoustic imaging and corneal or scleral biomechanics, which may lead to innovative treatment modalities for myopia.

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Quantitative OCT Angiography of the Retinal Microvasculature and the Choriocapillaris in Myopic Eyes

Abstract: The density of the retinal capillary microvasculature is reduced and the area of flow deficit in the CC is increased in eyes with greater myopia. The relevance of microvascular alterations in the setting of myopia warrants further study.

Cited by 259 publications

References 41 publications

Alterations in the Choriocapillaris in Intermediate Age-Related Macular Degeneration

Alterations in the Choriocapillaris in Intermediate Age-Related Macular Degeneration

Optical Coherence Tomography Angiography Offers New Insights into Choriocapillaris Perfusion

Imaging in myopia: potential biomarkers, current challenges and future developments

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