Quantitative NMR spectroscopy—Applications in drug analysis

Rapid quantification of 2-hydroxypropyl-β-cyclodextrin in liquid pharmaceutical formulations by 1H nuclear magnetic resonance spectroscopy

“…Since Nuclear Magnetic Resonance (NMR) spectroscopy is one of the most widely used techniques for understanding the interaction between CD and guest compounds (Bertholet et al, 2005;Higashi et al, 2009;Lis-Cieplak et al, 2014;Malet-Martino and Holzgrabe, 2011;Schneider et al, 1998;Vogt and Strohmeier, 2012;Yang et al, 2009) and to evaluate the number of substituted glucopyranose units (molar substitution), we aim to apply 1 H nuclear magnetic resonance spectroscopy ( 1 H NMR) to quantify 2-HP-b-CD in pharmaceutical solutions. Under controlled conditions, 1 H NMR spectroscopy is considered as quantitative given that the intensity of a signal is directly related to the amount of resonant nuclei (Holzgrabe et al, 2005). 1 H NMR spectroscopy could therefore be used for precise quantification of a specific substance (Pauli et al, 2012).…”

Towards Understanding Drugs on the Molecular Level to Design Drugs of Desired Profiles

“…A combination of experimental and theoretical techniques has certainly much to offer for the studies of drugs or potential drugs in early phases of drug research. Their capabilities in particular when applied to the known drugs, have been well documented in literature [92,99,101,104,105,148,[156][157][158][159][160][161][184][185][186][187][188][189]. Although in some fields the NMR or NQR are not competitive to IR, UV or XRD the examples of combined studies given above show that both techniques have a potential to elicit structural and physico-chemical information about a molecule of dug, target or the interaction drug-target.…”

An Evaluation of Prevalence of Low Quality of Medicines in Saudi Arabia and Factors Associated an Analytical Comparative Study

“…Degraded medicines may result from exposure of good-quality medicines to light, heat, and humidity. It can be difficult to distinguish degraded medicines from those that left the factory as substandard, but the distinction is important as the causes and remedies are different [26,27].…”