Quantitative multiparametric MRI in uveal melanoma: increased tumor permeability may predict monosomy 3

Kamrava, Mitchell; Sepahdari, Ali R.; Leu, Kevin; Wang, Pin-Chieh; Roberts, Karen; Demanes, D. Jeffrey; McCannel, Tara A.; Ellingson, Benjamin M.

doi:10.1007/s00234-015-1546-0

Cited by 24 publications

(40 citation statements)

References 22 publications

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“…Although it has been reported that the non-EPI TSE DWI is limited by poor SNR relative to the acquisition time [6], we found mostly a good quality, with restriction diffusion easy to appreciate even in small uveal melanomas (Figure 8). We noticed moreover that the DWI sequence with a b value of 400 s/mm 2 was not as good as the one with a b value of 800 s/mm 2 and of no additional value.…”

Section: Resultsmentioning

confidence: 63%

“…The MRI protocol to evaluate an UM should include functional images, such as DWI and PWI, which seem to be useful, although few studies have been published in UM [5,6,24,25].…”

Section: Discussionmentioning

confidence: 99%

“…The ideal imaging technique for the evaluation of UM needs to be capable of accurately delineating the limits of the tumor, of doing accurate measurements and of evaluating the presence of extrascleral extension, since these are the main determinants for the choice of the type of treatment, and in the case of radiotherapy for the radiotherapy planning. Additionally, noninvasive markers that can predict treatment response and prognosis are needed [5,6], in order to adjust the frequency and type of screening according to whether the patient is at high or low risk of developing disseminated disease, and because even if a biopsy is performed, it can be nonrepresentative, due to UM being heterogeneous in terms of chromosomal aberrations [7,8]. Finally, it should be able to assess tumor response to radiotherapy both in terms of size and internal structure at an early stage.…”

Section: Introductionmentioning

confidence: 99%

“…Imaging the eye with Magnetic Resonance Imaging (MRI) is a challenge due to eye motion and to the magnetic susceptibility effects at the air–bone interface. However, recent developments on MRI make it a promising diagnostic imaging modality in ophthalmology, due to its excellent soft tissue contrast and spatial resolution, as well as its possibility for generating functional images such as diffusion-weighted imaging (DWI) and perfusion-weighted imaging (PWI) [5,6,9]. UM is therefore more and more being evaluated with MRI [5,6,9,10,11].…”

Section: Introductionmentioning

confidence: 99%

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MRI of Uveal Melanoma

Ferreira

Fonk

Jaarsma-Coes

et al. 2019

Cancers

101

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Uveal Melanoma (UM) is the most common primary malignant ocular tumor. The high soft tissue contrast and spatial resolution, and the possibility of generating 3D volumetric and functional images, make Magnetic Resonance Imaging (MRI) a valuable diagnostic imaging technique in UM. Current clinical MRI protocols, however, are not optimized for UM and therefore lack the quality for accurate assessments. We therefore developed a dedicated protocol at a 3 Tesla MRI, using an eye coil, consisting of multi-slice 2D sequences, different isotropic sequences and diffusion and perfusion-weighted images. This protocol was prospectively evaluated in 9 uveal melanoma patients. The multi-slice 2D sequences had the highest in-plane resolution, being the most suited for lesion characterization and local extension evaluation. The isotropic 3D Turbo-Spin Echo (TSE) sequences were the most suitable for accurate geometric measurements of the tumor and are therefore important for therapy planning. Diffusion and perfusion-weighted images aid in differentiating benign from malignant lesions and provide quantitative measures on tumor hemodynamics and cellularity, which have been reported to be effective in predicting and assessing treatment outcome. Overall, this dedicated MRI protocol provides high-quality imaging of UM, which can be used to improve its diagnosis, treatment planning, and follow-up.

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Section: Resultsmentioning

confidence: 63%

“…The MRI protocol to evaluate an UM should include functional images, such as DWI and PWI, which seem to be useful, although few studies have been published in UM [5,6,24,25].…”

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

MRI of Uveal Melanoma

Ferreira

Fonk

Jaarsma-Coes

et al. 2019

Cancers

101

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“…Currently, however, these applications are mainly based on qualitative MRI methods using the large number of tissue contrasts addressable by MR. As an example, in Graves' ophthalmopathy fat-suppressed T 2 -weighted MRI is the standard to detect inflammation in the eye muscles, 4,5 whereas in the diagnosis of retinoblastoma, a rare intraocular cancer in children, standard T 1 -and T 2 -weighted MRI is often performed to confirm the presence of the tumor and to screen for potential optic nerve involvement. 2 In more recent ophthalmologic applications of MRI, such as uveal melanoma (the most common primary intraocular tumor), quantitative MRI techniques including DWI 6 and DCE imaging 7 have been shown, but currently diagnosis is still based on qualitative methods. 3 To personalize treatment plans quantitative parameters of the tissues involved, as can be acquired invasively for example by performing biopsies, 8 are highly desirable.…”

mentioning

confidence: 99%

Cartesian MR fingerprinting in the eye at 7T using compressed sensing and matrix completion‐based reconstructions

Koolstra

Beenakker

Koken

et al. 2018

Magnetic Resonance in Med

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Purpose To explore the feasibility of MR Fingerprinting (MRF) to rapidly quantify relaxation times in the human eye at 7T, and to provide a data acquisition and processing framework for future tissue characterization in eye tumor patients. Methods In this single‐element receive coil MRF approach with Cartesian sampling, undersampling is used to shorten scan time and, therefore, to reduce the degree of motion artifacts. For reconstruction, approaches based on compressed sensing (CS) and matrix completion (MC) were used, while their effects on the quality of the MRF parameter maps were studied in simulations and experiments. Average relaxation times in the eye were measured in 6 healthy volunteers. One uveal melanoma patient was included to show the feasibility of MRF in a clinical context. Results Simulation results showed that an MC‐based reconstruction enables large undersampling factors and also results in more accurate parameter maps compared with using CS. Experiments in 6 healthy volunteers used a reduction in scan time from 7:02 to 1:16 min, producing images without visible loss of detail in the parameter maps when using the MC‐based reconstruction. Relaxation times from 6 healthy volunteers are in agreement with values obtained from fully sampled scans and values in literature, and parameter maps in a uveal melanoma patient show clear difference in relaxation times between tumor and healthy tissue. Conclusion Cartesian‐based MRF is feasible in the eye at 7T. High undersampling factors can be achieved by means of MC, significantly shortening scan time and increasing patient comfort, while also mitigating the risk of motion artifacts.

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A Comparison of 3 T and 7 T MRI for the Clinical Evaluation of Uveal Melanoma

Tang

Jaarsma-Coes

Ferreira

et al. 2021

Magnetic Resonance Imaging

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Background Magnetic resonance imaging (MRI) is increasingly being used in the diagnosis and treatment planning of uveal melanoma (UM), the most common primary intraocular tumor. Initially, 7 T MRI was primarily used, but more recently these techniques have been translated to 3 T, as it is more commonly available. Purpose Compare the diagnostic performance of 3 T and 7 T MRI of UM. Study Type Prospective. Population Twenty‐seven UM patients (19% female). Field Strength/Sequence 3 T: T1‐ and T2‐weighted three‐dimensional (3D) spin echo (SE) and multi‐slice (MS) SE, 7 T: T1‐weighted 3D gradient echo (GE), T2‐weighted 3D SE and MS SE, 3 T and 7 T GE dynamic contrast‐enhanced. T1 weighted images: acquired before and after Gadolinium (Gd) administration. Assessment For all sequences, scan and diagnostic quality was quantified using a 5‐point Likert scale. Signal intensities on T1 and T2 relative to choroid and eye muscle respectively were assessed as well as the tumor prominence. Finally, the perfusion time‐intensity curves (TICs) were classified as plateau, progressive, or wash‐out. Statistical Tests Image quality scores were compared between both field strengths using Wilcoxon signed‐rank and McNemar tests. Paired t‐tests and Bland–Altman were used for comparing tumor prominences. P < 0.05 was considered statistically significant. Results Image quality was comparable between 3 T and 7 T, for 3DT1, 3DT2, 3DT1Gd (P = 0.86; P = 0.34; P = 0.78, respectively) and measuring tumor dimensions (P = 0.40). 2DT1 and 2DT2 image quality were rated better on 3 T compared to 7 T. Most UM had the same relative signal intensities at 3 T and 7 T on T1 (17/21) and T2 (13/17), and 16/18 diagnostic TICs received the same classification. Tumor prominence measurements were similar between field strengths (95% confidence interval: −0.37 mm to 0.03 mm, P = 0.097). Data Conclusion Diagnostic performance of the evaluated 3 T protocol proved to be as capable as 7 T, with the addition of 3 T being superior in assessing tumor growth into nearby anatomical structures compared to 7 T. Level of Evidence 2 Technical Efficacy Stage 3

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Quantitative multiparametric MRI in uveal melanoma: increased tumor permeability may predict monosomy 3

Cited by 24 publications

References 22 publications

MRI of Uveal Melanoma

MRI of Uveal Melanoma

Cartesian MR fingerprinting in the eye at 7T using compressed sensing and matrix completion‐based reconstructions

A Comparison of 3 T and 7 T MRI for the Clinical Evaluation of Uveal Melanoma

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