MRI of Uveal Melanoma

Ferreira, Teresa; Fonk, Lorna Grech; Jaarsma-Coes, Myriam G.; Haren, Guido G R van; Marinković, Marina; Beenakker, Jan-Willem M.

doi:10.3390/cancers11030377

Cited by 59 publications

(107 citation statements)

References 28 publications

(43 reference statements)

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“…Given the large FOV needed for the ZTE, such a scan would take at least six minutes to acquire a sufficient number of spokes, if not more, and to achieve a decent SNR. Such long scan times make the scan very susceptible to slow drifts in gazing direction [26] which blur out the fine anatomical details one aims to resolve using the high resolution. We therefore expect that a significant improvement of image resolution will not be easily possible, although finally in vivo measurements are needed to definitively confirm this.…”

Section: Discussionmentioning

confidence: 99%

Silent volumetric multi-contrast 7 Tesla MRI of ocular tumors using Zero Echo Time imaging

et al. 2019

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Magnetic Resonance Imaging (MRI) has become a valuable imaging modality in ophthalmology, especially for the diagnosis and treatment planning of patients with uveal melanoma, the most common primary intra-ocular tumor. We aim to develop and evaluate the value of silent Zero Echo Time (ZTE) MRI to image patients with ocular tumors at 7Tesla. Therefore, ZTE and different types of magnetization-prepared ZTE (FLAIR, SPIR, T2 and Saturation recovery), have been developed. After an initial validation with 7 healthy subjects, nine patients with an eye tumor have been evaluated. The ZTE scans were compared to their Cartesian equivalent in terms of contrast, motion-sensitivity, diagnostic quality and patient comfort. All volunteers and especially the patients reported a more comfortable experience during the ZTE scans, which had at least a 10 dB lower sound pressure. The image contrast in the native ZTE was poor, but in the different magnetization-prepared ZTE, the eye lens, cornea and retina were clearly discriminated. Overall the T2-prepared scan yielded the best contrast, especially between tumor and healthy tissue, and proved to be robust against eye motion. Although the intrinsic 3D nature of the ZTE-technique provides an accurate analysis of the tumor morphology, the quality of the ZTE-images is lower than their Cartesian equivalent. In conclusion, the quality of magnetization-prepared ZTE images is sufficient to assess the 3D tumor morphology, but insufficient for more detailed evaluations. As such this technique can be an option for patients who cannot comply with the sound-levels of Cartesian scans, but for other patients the conventional Cartesian scans offer a better image quality.

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Section: Discussionmentioning

confidence: 99%

Silent volumetric multi-contrast 7 Tesla MRI of ocular tumors using Zero Echo Time imaging

et al. 2019

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“…All MRIs were performed at a 3T MRI (wide bore Ingenia 3T, Philips Healthcare, Best, The Netherlands), using the setup we developed to scan the eyes of UM patients as described in reference [19]. A 4.7 cm surface receive coil (Philips Healthcare, Best, The Netherlands) was used, and the head was supported by a radiotherapy support (MaxSupportTM, Medeo, Schöftland, Switzerland).…”

Section: Mri Protocolmentioning

confidence: 99%

“…In Group 1 patients, for the evaluation of the healthy eyelid anatomy, the 2D multi-slice (MS) sequences, with 2 mm thickness and an in-plane resolution of at least 0.5 × 0.5 mm 2 were used [19]. These included T1 (TE/TR:8/718 ms) and T2 (TE/TR:90/1331 ms) weighted-images (WI) and a contrast-enhanced T1-WI (8/764 ms) with spectral presaturation with inversion recovery (SPIR) fat signal suppression.…”

Section: Mri Protocolmentioning

confidence: 99%

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MR and CT Imaging of the Normal Eyelid and its Application in Eyelid Tumors

Ferreira

Pinheiro

Saraiva

et al. 2020

Cancers

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T-staging of most eyelid malignancies includes the assessment of the integrity of the tarsal plate and orbital septum, which are not clinically accessible. Given the contribution of MRI in the characterization of orbital tumors and establishing their relations to nearby structures, we assessed its value in identifying different eyelid structures in 38 normal eyelids and evaluating tumor extension in three cases of eyelid tumors. As not all patients can receive an MRI, we evaluated those same structures on CT and compared both results. All eyelid structures were identified on MRI and CT, except for the conjunctiva on both techniques and for the tarsal muscles on CT. Histopathology confirmed the MRI findings of orbital septum invasion in one patient, and the MRI findings of intact tarsus and orbital septum in another patient. Histopathology could not confirm or exclude tarsal invasion seen on MRI on two patients. Although imaging the eyelid is challenging, the identification of most eyelid structures is possible with MRI and, to a lesser extent, with CT and can, therefore, have an important contribution to the T-staging of eyelid tumors, which may improve treatment planning and outcome.

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“…Anand and coworkers report on a pilot study of circulating tumor cells (CTCs) in early-stage UM that predict an increased risk of metastatic disease [40]. Ferreira et al provide a dedicated protocol for 3 Tesla magnetic resonance imaging for an improved diagnosis of uveal melanoma [44]. Frizziero et al review the state of the art of uveal melanoma biopsies [48].…”

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confidence: 99%