1982
DOI: 10.3109/10408448209037456
|View full text |Cite
|
Sign up to set email alerts
|

Quantitative morphological studies of neuropathological changes. Part 1

Abstract: Quantitation of morphological changes in the nervous system is valuable for demonstrating different regions and cell types involved in a pathological process. Quantitative anatomical studies are numerous, whereas quantitations of pathological conditions are relatively few. This seems to be due partly to technical difficulties arising when comparing normal with pathological brain tissue. Shrinkage of the whole brain or of substructures is important but difficult to determine, and earlier studies are often inacc… Show more

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
3
1
1

Citation Types

0
11
0

Year Published

1984
1984
2016
2016

Publication Types

Select...
7
1
1

Relationship

0
9

Authors

Journals

citations
Cited by 25 publications
(11 citation statements)
references
References 113 publications
0
11
0
Order By: Relevance
“…[34][35][36] Histology, however, requires harvest of the spinal cord, thereby precluding in vivo and real-time visualization of the spinal cord. Further, the isolation of the spinal cord releases the physiological tension that is present in the parenchyma and can therefore modify the morphology of the tissue, whereas the tissue fixation can provoke shrinkage of the tissue, [37][38][39] thereby limiting the findings of histological stereological studies. Many microhemorrhagic foci apparent on VHRUS were no longer detectable after histological processing of the spinal cord tissue.…”
Section: Discussionmentioning
confidence: 99%
“…[34][35][36] Histology, however, requires harvest of the spinal cord, thereby precluding in vivo and real-time visualization of the spinal cord. Further, the isolation of the spinal cord releases the physiological tension that is present in the parenchyma and can therefore modify the morphology of the tissue, whereas the tissue fixation can provoke shrinkage of the tissue, [37][38][39] thereby limiting the findings of histological stereological studies. Many microhemorrhagic foci apparent on VHRUS were no longer detectable after histological processing of the spinal cord tissue.…”
Section: Discussionmentioning
confidence: 99%
“…Extended dehydration using organic solvents and heat during paraffin embedding caused extensive shrinkage of the tissue [10]. Consequently the sizes of hemispheres, oedema and infarct are underestimated as absolute values using this procedure.…”
Section: Discussionmentioning
confidence: 99%
“…Stereological methods have been developed for many purposes (for review, c.f. Diemer, 1982;Gundersen, 1981;Weibel, 1979;Weibel, 1980), but they have only to a very limited extent been applied to the study of the testis (for review, c.f. Bolender, 1982; Muller & S kak ke baek , 1986).…”
Section: Evaluation Of the Methods Usedmentioning
confidence: 99%