Quantitative Methods in the Study of Pulmonary Pathology

Dunnill, M. S.

doi:10.1136/thx.17.4.320

Cited by 543 publications

(339 citation statements)

References 11 publications

(2 reference statements)

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“…The value of chest radiography for the assessment of emphysema has been a matter of contention since the 1960s [10]. In radiological-pathological correlation studies, the agreement between chest radiograph interpretation and morphological findings ranges from excellent [8] to poor [19], depending upon the radiographic criteria used and the strictness applied by the investigators in matching their interpretation to the presence or absence of structural emphysema [10].…”

Section: Discussionmentioning

confidence: 99%

“…In radiological-pathological correlation studies, the agreement between chest radiograph interpretation and morphological findings ranges from excellent [8] to poor [19], depending upon the radiographic criteria used and the strictness applied by the investigators in matching their interpretation to the presence or absence of structural emphysema [10]. Raters 1 and 2 were pulmonologists, raters 3 and 4 were medical students and …”

Section: Discussionmentioning

confidence: 99%

“…In their study, emphysema was correctly identified in ante-mortem chest radiographs in 82% of the patients who had autopsyproven emphysema. This represented any amount of emphysematous tissue destruction occupying .2% of total lung volume as measured by the point-counting technique [10]. By contrast, all of the chest radiographs corresponding to the patients with structurally normal lungs were rated as normal.…”

Section: Chest Radiographymentioning

confidence: 99%

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Value of chest radiography in phenotyping chronic obstructive pulmonary disease

Miniati¹,

Monti²,

Stolk³

et al. 2008

European Respiratory Journal

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The objectives of the present study were to reappraise chest radiography for the diagnosis of emphysema, using computed tomography (CT) as the reference standard, and to establish whether or not chest radiography is useful for phenotyping chronic obstructive pulmonary disease (COPD).Patients (n5154) who had undergone posteroanterior and lateral chest radiography and CT for diagnostic purposes were studied. CT data were scored for emphysema using the picture-grading method. Chest radiographs were examined independently by five raters using four criteria for emphysema that had been validated against lung pathology. These criteria were then used to assess the prevalence of emphysema in 458 COPD patients. Patients with and without evidence of emphysema were compared with regard to age, sex, smoking history, body mass index (BMI), forced expiratory volume in one second (FEV1), diffusing capacity of the lung for carbon monoxide (DL,CO) and health status.Chest radiography yielded a sensitivity of 90% and a specificity of 98% for emphysema. Of the 458 COPD patients, 245 showed radiological evidence of emphysema. Emphysemic patients had a significantly lower BMI, FEV1 and DL,CO, greater restriction of physical activity and worse quality of life than nonemphysemic patients. There was no difference across the two groups with regard to age, sex or smoking history.Chest radiography is a simple means of diagnosing moderate-to-severe emphysema. It is useful in phenotyping chronic obstructive pulmonary disease and may aid physicians in their choice of treatment.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Chest Radiographymentioning

confidence: 99%

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Value of chest radiography in phenotyping chronic obstructive pulmonary disease

Miniati¹,

Monti²,

Stolk³

et al. 2008

European Respiratory Journal

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“…To quantitate the effect of inflation the mean linear intercept (Lm), a measure for the average diameter of air spaces [5,6] was measured. In addition, the average length, width, perimeter and surface area of individual alveoli were analysed.…”

Section: Determination Of Parenchymal Dimensionsmentioning

confidence: 99%

Restoration by vacuum inflation of original alveolar dimensions in small human lung specimens

Kuppevelt¹,

Robbesom²,

Versteeg³

et al. 2000

Eur Respir J

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Resection of lung specimens results in deflated and distorted lung structures. If no major airway is present (as in the case of small lung specimens from biopsies), lung dimensions cannot be restored by inflation under 25 cmH 2 O. This impedes morphological analysis of the tissue. This report describes a simple and easy procedure to restore alveolar dimensions in deflated small lung specimens.Small human lung samples were inflated using moderate vacuum conditions which are provided by a common water stream-driven vacuum device. Restoration of alveolar dimensions and morphology was evaluated for paraffin-embedded as well as frozen tissue, using morphometric and immunohistological analysis.Vacuum inflation results in restoration of original lung dimensions as judged by light and scanning electron microscopy, and by analysis of the mean linear intercept, and the average length, width, perimeter and surface area. It also results in markedly improved cutting characteristics, allowing reliable sectioning of 2 mm cryosections and achieving high resolution images in immunofluorescence.Vacuum inflation is a simple and easy procedure to restore lung architecture of small human lung specimens/biopsies with a concomitant improvement of cutting characteristics. It allows for correct histological analysis of small specimens which cannot be inflated otherwise.

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“…Sutherland (1951) (Dunnill, 1968) (c) Degree of vascular invasion by tumour.-Choriocarcinoma has no integral vascular stroma, and the tumour invades the vasculature of the host in the same way as normal trophoblast. A consequence of this vascular permeation is the ease with which haematogenous metastasis takes place, and it is possible that the degree of vascular invasion is a factor in the response of patients to treatment.…”

Section: Therapymentioning

confidence: 99%

Cellular Reaction in Trophoblastic Tumours

Elston¹,

Bagshawe²

1973

Br J Cancer

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Summary.-The presence of a mononuclear cell reaction to 41 gestational choriocarcinomata, 10 invasive moles and 13 malignant trophoblastic teratomata has been investigated. The intensity of the reaction was graded; there was a significantly better response to therapy and survival rate in those with a " severe " cellular reaction than in those with a " mild " reaction to gestational choriocarcinoma. The pathological and clinical features of invasive moles showed no relationship with the cellular reaction to the tumour. The cellular reaction to trophoblastic teratomata was generally poor but there was a marked cellular reaction to the tumour of one patient who has enjoyed a sustained remission.The relationship of cellular reaction and response to treatment with other histological and clinical features was examined. With the exception of a positive correlation between the degree of vascular invasion and response to treatment, none was found.It is suggested that an infiltrate of mononuclear cells in gestational choriocarcinoma is probably a response to the presence of tumour antigens. The infiltrate favourably affects the response to chemotherapeutic agents, suggesting that it contributes to tumour cell death and it may be interpreted as an immunological response directed at tumour rejection.

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Quantitative Methods in the Study of Pulmonary Pathology

Cited by 543 publications

References 11 publications

Value of chest radiography in phenotyping chronic obstructive pulmonary disease

Value of chest radiography in phenotyping chronic obstructive pulmonary disease

Restoration by vacuum inflation of original alveolar dimensions in small human lung specimens

Cellular Reaction in Trophoblastic Tumours

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