Quantitative Measurements of Cerebral Blood Flow in the Macacque Monkey

Dumke, Paul; Schmidt, Carl F.

doi:10.1152/ajplegacy.1943.138.3.421

Cited by 132 publications

(31 citation statements)

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“…Methylergometrine and dihydroergotamine decreased the cerebral blood flow without producing any change in the oxygen consumption of the brain, confirming previous reports of a significant cerebral vasoconstriction (Dumke & Schmidt, 1943;Carpi & Virno, 1957) produced by ergot alkaloids.…”

Section: X2supporting

confidence: 89%

Effects of drugs on the cerebral circulation of the dog in relation to the cerebral oxygen consumption

Chin

Imai

Nakano

et al. 1983

British J Pharmacology

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1Drug effects were studied on the cerebral circulation by measuring the sagittal sinus outflow in the anaesthetized dog following the method of Michenfelder and by monitoring cerebral oxygen consumption. Systemic aortic pressure, heart rate and spinal fluid pressure were also studied. 2 Since dilatation of cerebral vessels was observed in nearly all the preparations after inhalation of C02, it was thought that gross extracerebral contamination was virtually eliminated in this preparation. A close correlation was observed between the oxygen consumption of the brain as a whole and the sagittal sinus outflow (r= 0.93, P< 0.001); therefore it became feasible to differentiate the direct effects of drugs on cerebral blood vessels from indirect ones attributable to changes in the cerebral oxidative metabolism. 3 Sodium pentobarbitone (5 mg kg-1, i.v.), reduced the cerebral venous outflow and caused a decrease in the oxygen consumption. Pentylenetetrazol (30 mg kg -i.v.) and bemegride (5 mg kg-1 i.v.) produced an increase in the blood flow and a corresponding increase in the cerebral oxygen consumption. Thus, it was concluded these substances had no direct effects on the cerebral blood vessels. 4 Acetazolamide (10mgkg-1, i.v.), a carbonic anhydrase inhibitor, produced a marked and sustained vasodilatation after a latent period of 0.5-1 min. There was no increase in the cerebral oxygen consumption. A similar pattern was seen after CO2 had been inhaled. Methylergometrine and dihydroergotamine (20 jig kg-1 i.v.) induced a prolonged vasoconstriction of the cerebral vascular bed without any changes in the oxygen consumption of the brain. Therefore this method can discriminate between indirect or direct effects of drugs on cerebral vascular outflow.

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Section: X2supporting

confidence: 89%

Effects of drugs on the cerebral circulation of the dog in relation to the cerebral oxygen consumption

Chin

Imai

Nakano

et al. 1983

British J Pharmacology

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“…Origi nally, theophylline was thought to be a cerebral va sodilator (Wolff, 1936;Noell, 1942;Dumke and Schmidt, 1943;Gottstein et aI., 1961), and it has been demonstrated to reverse acute cerebral vaso spasm following subarachnoid hemorrhage in monkeys and cats (Flamm et aI., 1975). On the other hand, cerebral vasoconstriction has been found during theophylline treatment in humans (Gottstein and Paulson, 1972).…”

Section: Discussionmentioning

confidence: 99%

Effect of Theophylline on Ischemically Induced Hippocampal Damage in Mongolian Gerbils: A Behavioral and Histopathological Study

Rudolphi¹,

Keil

Hinze³

1987

J Cereb Blood Flow Metab

142

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Summary:We investigated the influence of the adenosine antagonist theophylline on the degree of hippocampal cell damage in the Mongolian gerbil following brief periods of forebrain ischemia. Male gerbils were randomly divided into nine groups. Te n minutes before surgery, four groups, which were later subjected to I, 2, 3, or 5 min of bilateral carotid occlusion under halothane anesthesia, received theophylline (30 mg/kg, p.o.). Four groups served as nontreated ischemic controls; the ninth group was used to measure theophylline serum concentration. Neurological symptoms were classified by using a behav ioral score. Fourteen days after ischemia, the brains were removed, and the hippocampus was histologically exam ined "blind" for the degree of cell damage in the CAl sector, which was expressed as a semiquantitative histo-

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“…The ability of cerebral vessels to dilate in vivo in response to exogenous acetylcholine has been ex tensively documented over the years (Wolff, 1929;Michelazzi, 1934;Norcross, 1938;Koopmans, 1939;Dumke and Schmidt, 1943;Scremin et aI., 1973;Kuschinsky et aI., 1974;Heistad et aI., 1980). Further more, a role of endogenously released acetylcholine in control of cerebral blood flow (CBF) is implied by the ability of the cholinesterase inhibitor phy sostigmine to increase cortical blood flow in the ab sence of metabolic activation (Scremin et aI., 1982b), the blockade by atropine of several physiological adjustments of CBF (Mchedlishvili and Nikolaish viIi, 1970;Rovere et aI., 1973;Scremin et aI.…”

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confidence: 99%

Cholinergic Cerebral Vasodilatation: Lack of Involvement of Cranial Parasympathetic Nerves

Scremin¹,

Sonnenschein²,

Rubinstein³

1983

J Cereb Blood Flow Metab

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Cerebral blood flow (CBF) was estimated by measurement of internal carotid blood flow (ICBF) and sagittal sinus blood flow (SSBF) in mechanically ventilated rabbits under 70% N2O/30% O2. Electrical stimulation of cranial nerves III, VII, IX, or X, with stimulus parameters adequate to excite other visceromotor outflows of these nerves, failed to elicit change in CBF. Combined bilateral section of nerves VII, VIII, IX, X, and XI had no effect on the reactivity of CBF to CO2, nor did the sectioning of these nerves affect the increases in CBF induced by physostigmine. Division of the sinus and aortic nerves and of the vagi in the neck failed to change CO2 reactivity, even though normocapnic CBF was reduced. Pentobarbital blocked the increase in CBF produced by physostigmine, but had no effect on that produced by pilocarpine. The results indicate that cranial parasympathetic nerves do not contain cerebral vasodilator fibers, and that they are not the source of acetylcholine which is presumably involved in CBF regulation.

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Quantitative Measurements of Cerebral Blood Flow in the Macacque Monkey

Cited by 132 publications

References 0 publications

Effects of drugs on the cerebral circulation of the dog in relation to the cerebral oxygen consumption

Effects of drugs on the cerebral circulation of the dog in relation to the cerebral oxygen consumption

Effect of Theophylline on Ischemically Induced Hippocampal Damage in Mongolian Gerbils: A Behavioral and Histopathological Study

Cholinergic Cerebral Vasodilatation: Lack of Involvement of Cranial Parasympathetic Nerves

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