Gas turbines are widely used in e.g., power generation, and aero-industries. Due to global warming, the demand for more efficient gas turbines has increased. A way to achieve this is by increasing the operating temperature of gas turbines. Therefore, nickel-based superalloys have been developed to withstand these extreme temperatures and loads, especially in the hot sections.Today, the way of operating land-based gas turbines is changing. Instead of running for long periods of time, the operation is becoming more flexible, with everincreasing cyclic loads and number of start and stop cycles. To handle the increased stress and cycles, component resistance to fatigue failure needs to be improved.Surface integrity is critical to fatigue performance, since fatigue cracks are normally initiated at surfaces. Nickel-based superalloys are difficult-to-machine materials, primarily due to their high strength, high tendency for work-hardening, and low thermal conductivity. The machining process changes the surface integrity of the alloys which can result in worse fatigue resistance.The work presented in this Ph.D. thesis was conducted in collaboration with Siemens Industrial Turbomachinery AB in Finspång, Sweden. Surface integrity changes which are induced during machining and their effects on fatigue performance have been studied on alloy Inconel 718. Inconel 718 is a widely-used nickel-based superalloy for high temperature applications in modern gas turbines.Broaching, milling, and wire electrical discharge machining, related to component manufacturing in turbo machinery industries, were included in this study. Surface irregularity and defects induced by machining provide preferential sites for fatigue crack initiation which influence the fatigue performance of the alloy. If compressive residual stresses are induced during machining, they benefit the fatigue life by retarding fatigue crack initiation away from surface regions. Shot peening was performed on machined Inconel 718, by which high compressive residual stresses are deliberately induced. It results in increased fatigue performance. The high iv temperatures in gas turbines generally deteriorate the surface integrity. For instance, recrystallization often occurs in the highly plastically-deformed surface layer. Microstructural degradation, in a form of α-Cr precipitates, have also been observed in the deformed surface and sub-surface microstructure when subjected to thermal exposure. Oxidation at elevated temperatures was found to degrade the surface integrity and thereby also the fatigue performance. Fatigue cracks are preferably initiated at oxidized surface carbides, if thermal exposure has been made prior to the test, and a reduced fatigue life is often obtained. It is even worse when high temperatures relax the beneficial compressive residual stresses induced by shotpeening and thereby lowering the fatigue resistance. This increases the interest for research regarding how to optimize the shot peening process in order to enhance the thermal stability o...