Quantitative Measurement of Cortical Surface Features in Localization-Related Temporal Lobe Epilepsy.

Oyegbile, Temitayo O.; Hansen, R.; Magnotta, Vincent A.; O'Leary, Daniel S.; Bell, Brian; Seidenberg, Michael; Hermann, Bruce P.

doi:10.1037/0894-4105.18.4.729

Cited by 42 publications

(46 citation statements)

References 31 publications

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“…Moreover, only half of the patients had mesiotemporal sclerosis. The direction of our findings favoring increased sulco-gyral folding complexity is in agreement with data from another study, 7 although the exact anatomic localization was not provided.…”

Section: Relationship Between Curvature and Clinical Measuressupporting

confidence: 90%

“…21 This initial observation has since been extended in a few automated wholebrain studies of cortical complexity, with inconsistent results. [7][8][9] While our present findings appear at odds with the decreased multilobar fractal dimension previously reported, 8 the nonspecific nature of the fractal dimension measurement limits a direct comparison with our method. Another publication reported a nonlocalized trend toward increased folding as assessed by isoperimetric ratio.…”

Section: Relationship Between Curvature and Clinical Measurescontrasting

confidence: 84%

“…Sulco-gyral patterns are thought to be a footprint of cortical develop-ment. Previous studies using automated measures of gyrification in TLE reported divergent findings, including increased gyral curvature, 7 decreased fractal dimension, 8 and no significant changes. 9 Notably, these studies used different indexes of folding complexity and provided only a single measure at the lobar or whole-brain level, lacking sensitivity to focal changes.…”

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confidence: 82%

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Increased temporolimbic cortical folding complexity in temporal lobe epilepsy

et al. 2011

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Objective: Converging evidence suggests that abnormalities of brain development may play a role in the pathogenesis of temporal lobe epilepsy (TLE). As sulco-gyral patterns are thought to be a footprint of cortical development, we set out to quantitatively map folding complexity across the neocortex in TLE. Additionally, we tested whether there was a relationship between cortical complexity and features of hippocampal maldevelopment, commonly referred to as malrotation. Methods:To quantify folding complexity, we obtained whole-brain surface-based measures of absolute mean cortical curvature from MRI scans acquired in 43 drug-resistant patients with TLE with unilateral hippocampal atrophy, and 40 age-and sex-matched healthy controls. In patients, we correlated changes in cortical curvature with 3-dimensional measures of hippocampal positioning. Results:We found increased folding complexity in the temporolimbic cortices encompassing parahippocampal, temporopolar, insular, and fronto-opercular regions. Increased complexity was observed ipsilateral to the seizure focus in patients with left TLE (LTLE), whereas these changes were bilateral in patients with right TLE (RTLE). In both TLE groups, increased temporolimbic complexity was associated with increased hippocampal malrotation. We found tendencies for increased complexity in bilateral posterior temporal cortices in LTLE and contralateral parahippocampal cortices in RTLE to be predictive of unfavorable seizure outcome after surgery. Conclusion:The anatomic distribution of increased cortical complexity overlapping with limbic seizure networks in TLE and its association with hippocampal maldevelopment further imply that neurodevelopmental factors may play a role in the epileptogenic process of TLE. Neurology Growing evidence suggests abnormalities of brain development are etiologic factors contributing to the pathogenesis of temporal lobe epilepsy (TLE). Although hippocampal sclerosis is the histopathologic hallmark of this condition, detailed studies have shown concurrent abnormal dispersion of granule cells, remnant fetal Cajal-Retzius cells, and changes in architectural organization of CA1 and dentate gyrus indicative of underlying hippocampal developmental abnormalities.1 Additional data revealed increased temporal lobe white matter neuronal clustering 2 and abnormal cortical myelinated fibers resembling those found in malformations of cortical development.3,4 While current MRI techniques cannot readily identify these small-scale features, macroscopic markers of hippocampal maldevelopment (referred to as malrotation), identified as atypical shape and positioning, are found in 40% of patients with TLE. 5,6 The anatomic location and extent of potential cortical developmental anomalies in TLE remain largely unknown. Sulco-gyral patterns are thought to be a footprint of cortical developEditorial, page 117

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Section: Relationship Between Curvature and Clinical Measuressupporting

confidence: 90%

Section: Relationship Between Curvature and Clinical Measurescontrasting

confidence: 84%

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confidence: 82%

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Increased temporolimbic cortical folding complexity in temporal lobe epilepsy

et al. 2011

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“…Baxendale et al (18) reported poorer global memory scores in patients with extratemporal pathology relative to patients without extratemporal pathology. Finally, Oyegbile et al (19) found an association between increased whole-brain gyrification in patients with TLE and poorer performances on a variety of cognitive measures. These studies all used whole brain or lobar quantitative MRI measures.…”

Section: Imaging Of Structure and Metabolites In Epilepsy 21 Volumetmentioning

confidence: 99%

The use of neuroimaging to study behavior in patients with epilepsy

McDonald¹

2008

Epilepsy & Behavior

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Structural and functional neuroimaging continue to play an increasing role in the presurgical evaluation of patients with epilepsy. In addition to their value for localizing the epileptogenic zone and eloquent cortex, neuroimaging is contributing to our understanding of mood comorbidity in epilepsy. Although the vast majority of research has focused on patients with temporal lobe epilepsy (TLE), neuroimaging studies of patients with frontal lobe epilepsy (FLE) and primary generalized epilepsy are increasing in number. In this review, structural and functional imaging modalities that have received considerable research attention in recent years are reviewed, along with an assessment of their strengths and limitations for understanding behavior in epilepsy. In addition, advances in multimodal imaging are discussed along with their potential application to the presurgical evaluation of patients with seizure disorders.

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“…It was recently used to compare gyrification in preterm and full-term children [Kesler et al, 2006]. It has been widely applied to assess gyrification patterns in adults with different neurological disorders including schizophrenia [Kulynych et al, 1997, Vogeley et al, 2000, White et al, 2003, Sallet et al, 2003, Harris et al, 2004, temporal lobe epilepsy [Oyegbile et al, 2004], Williams syndrome [Schmitt et al, 2002], and dyslexia [Casanova et al, 2004].…”

Section: Measures To Quantify Brain Surface Foldingmentioning

confidence: 99%