Quantitative Mass Spectrometric Analysis of Autoantibodies as a Paradigm Shift in Autoimmune Serology

Lee, Adrian Y S; Chataway, Tim; Colella, Alex D.; Gordon, Thomas P.; Wang, Jing J.

doi:10.3389/fimmu.2019.02845

Cited by 17 publications

(10 citation statements)

References 31 publications

(34 reference statements)

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“…Mass spectrometry is being increasingly adopted to study the molecular composition of proteins such as autoantibodies. 47 Analysis of the heavy and light chains of precipitating anti-dsDNA has been performed showing stereotyped heavy and light chain usage with shared mutations. 48 This suggests a common origin for these autoantibodies and may provide an opportunity for understanding the origin and pathogenicity of these autoantibodies beyond the isotype.…”

Section: Discussionmentioning

confidence: 99%

IgA anti-dsDNA antibodies: A neglected serological parameter in systemic lupus erythematosus

Lee

2022

Lupus

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Anti-double-stranded DNA (anti-dsDNA) autoantibodies are archetypal biomarkers found in systemic lupus erythematosus (SLE). Although they can exist in any isotype, very little is understood about the IgA isotype for which most of our knowledge is derived from observational studies. This review article summarises our knowledge of this autoantibody isotype to date. Attention will be spent on clinical associations as well as its potential links with lupus nephritis for which there is still some controversy. Further understanding of this serological parameter may facilitate diagnosis, prognosis and treatments of systemic lupus erythematosus patients.

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Section: Discussionmentioning

confidence: 99%

IgA anti-dsDNA antibodies: A neglected serological parameter in systemic lupus erythematosus

Lee

2022

Lupus

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“…As some of the most important biomarkers in autoimmunity, 17 the appearance of autoantibodies and why GA become the target of autoantibodies is not clear. It is possible that during excess cell apoptosis, these cytoplasmic structures become cleaved and exposed, creating neoantigens for targeting 3 .…”

Section: Discussionmentioning

confidence: 99%

Clinical associations of serum Golgi apparatus antibodies in an immunology laboratory cohort

et al. 2021

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Introduction Anti‐Golgi antibodies (AGAs) are rare antibodies that are found as distinct, polarised cytoplasmic staining on the HEp‐2 substrate. Methods We performed a review of patients that demonstrated this autoantibody in a large laboratory cohort in Australia. Over a 24‐month period, all patients that had a sample submitted for routine antinuclear antibodies (ANAs) that had AGA staining were retrospectively identified. Medical records were perused to identify clinical associations. Results There were 23 813 ANAs identified with 34 patients (0.14%) demonstrating AGA staining. AGAs were found in a variety of inflammatory disorders, malignancies and liver diseases. They did not associate with any other significant ANA, and in contrast with previous studies, we did not find any association with systemic autoimmune rheumatic diseases. Conclusions Anti‐Golgi antibodies are rare, non‐specific and possibly a bystander phenomenon. Future studies are required to study the origin and longitudinal clinical associations of these autoantibodies.

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“…In the changing landscape of autoimmune diagnostics, there is a greater need to provide better tailored information for the clinician and patient, and MS may contribute to this effort (16). It is conceivable that, through further study, it may be possible to establish which subfamilies correlate with clinical parameters and offer differential prognostic data.…”

Section: Figurementioning

confidence: 99%

Proteomic mapping of rheumatoid factors in early rheumatoid arthritis

Wang

Lee

Colella

et al. 2020

Arthritis & Rheumatology

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Quantitative Mass Spectrometric Analysis of Autoantibodies as a Paradigm Shift in Autoimmune Serology

Cited by 17 publications

References 31 publications

IgA anti-dsDNA antibodies: A neglected serological parameter in systemic lupus erythematosus

IgA anti-dsDNA antibodies: A neglected serological parameter in systemic lupus erythematosus

Clinical associations of serum Golgi apparatus antibodies in an immunology laboratory cohort

Proteomic mapping of rheumatoid factors in early rheumatoid arthritis

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