Proteomic mapping of rheumatoid factors in early rheumatoid arthritis

Wang, Jing J.; Lee, Adrian Y S; Colella, Alex D.; Chataway, Tim; Gordon, Thomas P.; Wechalekar, Mihir D.

doi:10.1002/art.41446

Cited by 5 publications

(2 citation statements)

References 16 publications

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“…Fibroblasts and inflammatory cells in synovial have significant changes in the development and the occurrence of diseases. At the same time, the expression of numerous molecules such as rheumatoid factors (RF) plays a guidance part in different severity and treatment of disease [ 80 ]. Horizontal comparisons between diseases and longitudinal changes over time revealed the differences and interactions between different cells in RA from different perspectives, which can be used as markers, as well as therapeutic targets.…”

Section: Single-cell Sequencing Applications In Rdsmentioning

confidence: 99%

Single-Cell Sequencing in Rheumatic Diseases: New Insights from the Perspective of the Cell Type

Ding¹,

Li²,

Zhu³

et al. 2022

Aging and disease

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Rheumatic diseases are a group of highly heterogeneous autoimmune and inflammatory disorders involving multiple systems. Dysfunction of immune and non-immune cells participates in the complex pathogenesis of rheumatic diseases. Therefore, studies on the abnormal activation of cell subtypes provided a specific basis for understanding the pathogenesis of rheumatic diseases, which promoted the accuracy of disease diagnosis and the effectiveness of various treatments. However, there was still a far way to achieve individualized precision medicine as the result of heterogeneity among cell subtypes. To obtain the biological information of cell subtypes, single-cell sequencing, a cutting-edge technology, is used for analyzing their genomes, transcriptomes, epigenetics, and proteomics. Novel results identified multiple cell subtypes in tissues of patients with rheumatic diseases by single-cell sequencing. Consequently, we provide an overview of recent applications of single-cell sequencing in rheumatic disease and cross-tissue to understand the cell subtypes and functions.

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Section: Single-cell Sequencing Applications In Rdsmentioning

confidence: 99%

Single-Cell Sequencing in Rheumatic Diseases: New Insights from the Perspective of the Cell Type

Ding¹,

Li²,

Zhu³

et al. 2022

Aging and disease

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“…Macroscopic, 61‐66 microscopic, 67‐73 and molecular 74‐82 features of synovium were characterized, with a particular interest in early disease states, 83‐96 including pre‐clinical 97‐100 and even normal synovium 101 . Differences between various disease states were discerned 102‐116 .…”

Section: Synovial Disordersmentioning

confidence: 99%

Will rheumatologists ever pick up the arthroscope again?

Ike

Kalunian

2021

Int J of Rheum Dis

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Conditions prompting physicians and surgeons first adapting endoscopes to peer into joints were mainly the sort of synovial conditions that would concern today's rheumatologists. Rheumatologists were among the pre‐World War II pioneers developing and documenting arthroscopy. The post‐War father of modern arthroscopy, Watanabe, found rheumatologists among his early students, who took back the technique to their home countries, teaching orthopedists and rheumatologists alike. Rheumatologists described and analyzed the intra‐articular features of their common diseases in the ’60s and ’70s. A groundswell of interest from academic rheumatologists in adapting arthroscopy grew considerably in the ’90s with development of “needle scopes” that could be used in an office setting. Rheumatologists helped conduct the very trials the findings of which reduced demand for their arthroscopic services by questioning the efficacy of arthroscopic debridement in osteoarthritis (OA) and also developing biological compounds that greatly reduced the call for any resective intervention in inflammatory arthropathies. The arthroscope has proven an excellent tool for viewing and sampling synovium and continues to serve this purpose at several international research centers. While cartilage is now imaged mainly by magnetic resonance imaging, some OA features – such as a high prevalence of visible calcinosis – beg further arthroscopy‐directed investigation. A new generation of “needle scopes” with far superior optics awaits future investigators, should they develop interest.

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