Quantitative mapping of basal and vasareactive cerebral blood flow using split-dose 123I-iodoamphetamine and single photon emission computed tomography

Cerebral Hemodynamic Benefits after Contralateral Carotid Artery Stenting in Patients with Internal Carotid Artery Occlusion

“…Before and 3-6 months after CAS, resting CBF and CVR were measured in 1 session by using the dual-table au-toradiographic method and dual administration of 123 I-IMP, as described in detail elsewhere. 20 For the dual-table autoradiographic method, 2 dynamic scans were acquired in quick succession, with a 2-minute interval between scans. The first scan covered the initial period from 0 to 28 minutes, and the second scan was acquired from 30 to 58 minutes.…”

Multicenter Evaluation of a Standardized Protocol for Rest and Acetazolamide Cerebral Blood Flow Assessment Using a Quantitative SPECT Reconstruction Program and Split-Dose 123I-Iodoamphetamine

“…The QSPECT package reconstructs images from the original projection data from commercial SPECT equipment, based on previous work by Iida and his colleagues (19)(20)(21)23,33,34). Reconstructed SPECT images are calibrated in Bq/mL, which provides independence from scanning parameters such as the acquisition time, number of views, matrix size, and zoom factor.…”

“…The attenuation m-maps were forward projected to provide the transmission projection data for TDCS. The emission projections were scatter-corrected by the TDCS method, as originally proposed by Meikle et al (18), and further optimized for realistic 99m Tc, 201 Tl, and 123 I data in the brain and thorax regions (20,21,23,33,34). An offset compensated for the septal penetration of high-energy photons for 123 I studies, which adds fairly uniform background counts, or direct current (DC) components, to the projections.…”

“…This was accomplished by using the dual-table autoradiographic (DTARG) method and a dual administration of 123 I-iodoamphetamine (23). In those studies, corrections for attenuation and scatter appeared to be essential for generating quantitative CBF maps that were consistent with those generated by 15 O-water PET (11,23).These studies were, however, validated in a single institution using a limited range of SPECT systems, and the general applicability of this technique for different SPECT systems had yet to be fully established. Thus, the aim of this study was to verify that analysis of data with a standardized reconstruction package incorporating attenuation and scatter correction can provide reproducible results across multiple institutions for quantitative rest and acetazolamide challenge CBF estimation from a single SPECT session.…”

The Need for Quantitative SPECT in Clinical Brain Examinations

“…The object was to make the quantitative assessment of the rest-and acetazolamide-CBF images from scans obtained in a single session, with two injections of 123 I-IMP at 30 min intervals, to establish the ischemic status in the scans of each patient. A sophisticated compartment model was applied (called dualtable ARG) [27] to make it possible for the stress CBF images to be calculated using table look-up procedures without the need for image subtraction. This method appeared not to result in increases in statistical noise and more importantly was able to provide quantitative CBF images with minimal errors and only little inconsistency between the rest-and acetazolamide-CBF assessments.…”