The Need for Quantitative SPECT in Clinical Brain Examinations

Abstract

This report describes details of the requirements and practical procedures for quantitative assessments of biological functional parametric images of the brain using 123 I-labeled tracers and clinical SPECT systems. With due understanding of the physics and the biological background, this is considered achievable even under clinical environments, provided that data are appropriately acquired, processed, and analyzed. This article discusses how potential hurdles have been overcome for quantitatively assessing quantitative functional parametric images in clinical settings, with successful examples that provided additional clinically useful information.