Quantitative imaging of zinc, copper and lead in three distinct regions of the human brain by laser ablation inductively coupled plasma mass spectrometry

Dobrowolska, Justina; Dehnhardt, Markus; Matusch, Andreas; Zoriy, Miroslav; Palomero‐Gallagher, Nicola; Kościelniak, Paweł; Zilles, Karl; Becker, J. Sabine

doi:10.1016/j.talanta.2007.06.051

Cited by 115 publications

(110 citation statements)

References 22 publications

Supporting

Mentioning

107

Contrasting

Order By: Relevance

“…41 Element distributions in rat and human brain tissue sections have been investigated by LA-ICP-SFMS. 42,43 Pb showed a more or less homogeneous distribution in human brain whereas Zn and Cu were found in higher concentrations in the hippocampus. Laser ablation ICP-SFMS was used for the determination and spatial elemental profiling of Ni concentrations in tissues that had been exposed to nickel wire.…”

Section: Biological and Environmental Samplesmentioning

confidence: 94%

Inductively coupled plasma- and glow discharge plasma-sector field mass spectrometry : Part II. Applications

Jakubowski

Prohaska

Vanhaecke

et al. 2011

J. Anal. At. Spectrom.

View full text Add to dashboard Cite

show abstract

Section: Biological and Environmental Samplesmentioning

confidence: 94%

Inductively coupled plasma- and glow discharge plasma-sector field mass spectrometry : Part II. Applications

Jakubowski

Prohaska

Vanhaecke

et al. 2011

J. Anal. At. Spectrom.

View full text Add to dashboard Cite

show abstract

“…A disadvantage of this method is the timeconsuming and complex preparation of calibration standards at several different concentration levels. 25 The preparation of matrix-matched standards is also very time consuming and complex [26][27][28][29][30] and must be especially adaptable to biological samples. In addition to these problems the homogeneity of matrix-matched standards is oen insufficient, which decreases the accuracy.…”

Section: -14mentioning

confidence: 99%

A calibration strategy for LA-ICP-MS using isotope dilution for solid reference materials

Thieleke

Vogt

2016

J. Anal. At. Spectrom.

View full text Add to dashboard Cite

An isotope dilution method for the quantitative analysis of trace elements in biological samples and for the characterization of reference materials for the analysis of biological samples by laser ablation-inductively coupled plasma-mass spectrometry (LA-ICP-ID-MS) has been tested. Polymeric thin layers with 5-10 mm thickness containing the ID-spike and the correction standard were produced by knife application onto polyester substrates. For the ID experiments 204 Pb enriched lead was used, and bismuth served as the internal standard. The layers showed good homogeneity of the layer thickness and the distribution of added elements. For the testing of the ID method, a synthetic sample with lead and a lead containing polymer certified reference material (BAM H010) have been used. Mass fractions for lead calculated after single and double isotope dilution experiments in the test samples showed a deviation of less than 1% from the certified values.

show abstract

“…Quantitative imaging of elements by MS in biological tissues is a challenging task in analytical chemistry and is relevant in different areas of biological and medical research. Becker et al [3,9,43] have investigated two-dimensional imaging of trace elements (e.g. Cu, Zn, Pb, P and S) in thin tissue sections of human and rat brains by LA-ICP-SFMS to employ them as indicators to monitor health risks.…”

Section: Laser Ablation Inductively Coupled Plasma Mass Spectrometrymentioning

confidence: 99%

Inorganic mass spectrometry as a tool for characterisation at the nanoscale

et al. 2009

View full text Add to dashboard Cite

Inorganic mass spectrometry techniques may offer great potential for the characterisation at the nanoscale, because they provide unique elemental information of great value for a better understanding of processes occurring at nanometre-length dimensions. Two main groups of techniques are reviewed: those allowing direct solid analysis with spatial resolution capabilities, i.e. lateral (imaging) and/or indepth profile, and those for the analysis of liquids containing colloids. In this context, the present capabilities of widespread elemental mass spectrometry techniques such as laser ablation coupled with inductively coupled plasma mass spectrometry (ICP-MS), glow discharge mass spectrometry and secondary ion/neutral mass spectrometry are described and compared through selected examples from various scientific fields. On the other hand, approaches for the characterisation (i.e. size, composition, presence of impurities, etc.) of colloidal solutions containing nanoparticles by the well-established ICP-MS technique are described. In this latter case, the capabilities derived from the on-line coupling of separation techniques such as field-flow fractionation and liquid chromatography with ICP-MS are also assessed. Finally, appealing trends using ICP-MS for bioassays with biomolecules labelled with nanoparticles are delineated.

show abstract

Quantitative imaging of zinc, copper and lead in three distinct regions of the human brain by laser ablation inductively coupled plasma mass spectrometry

Cited by 115 publications

References 22 publications

Inductively coupled plasma- and glow discharge plasma-sector field mass spectrometry : Part II. Applications

Inductively coupled plasma- and glow discharge plasma-sector field mass spectrometry : Part II. Applications

A calibration strategy for LA-ICP-MS using isotope dilution for solid reference materials

Inorganic mass spectrometry as a tool for characterisation at the nanoscale

Contact Info

Product

Resources

About