Quantitative hepatitis B surface antigen predicts the antiviral response and hepatocellular carcinoma development in patients with chronic hepatitis B

Kim, Sung Eun

doi:10.3904/kjim.2017.209

Cited by 3 publications

(3 citation statements)

References 14 publications

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“…Case-control and cohort studies have already shown that there is a significant dose-response relationship between serum HBV DNA levels measured at baseline and subsequent cirrhosis risk. Likewise, a similar relationship has been shown for the risk of hepatocellular carcinoma (HCC) (1)(2)(3)(4)(5). A strong correlation between the disease Giriş ve Amaç: Hepatit B virüsü nedeniyle siroz gelişen hastalarda Child-Pugh evresine göre HBV DNA düzeylerini karşılaştırmak.…”

Section: Introductionmentioning

confidence: 64%

“…Serum hepatitis B virus (HBV) DNA level has been previously shown to be an important and independent risk factor for the disease progression in chronic hepatitis B (1). Case-control and cohort studies have already shown that there is a significant dose-response relationship between serum HBV DNA levels measured at baseline and subsequent cirrhosis risk.…”

Section: Introductionmentioning

confidence: 99%

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Sirozlu hastalarda Child-Pugh evresine göre Hepatit B Virüs DNA seviyeleri

Değirmencioğlu

Seçkin

2018

Akademik Gastroenteroloji Dergisi

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activity index in liver biopsy and serum HBV DNA levels as well (4). From this point of view, we believe that determining the HBV DNA level is of paramount importance in terms of disease activity, determination of prognosis, and planning of the management. Therefore, the objective of this study was to compare HBV DNA levels according to Child-Pugh stage in patients who developed cirrhosis due to hepatitis B virus infection.

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Section: Introductionmentioning

confidence: 64%

Section: Introductionmentioning

confidence: 99%

Sirozlu hastalarda Child-Pugh evresine göre Hepatit B Virüs DNA seviyeleri

Değirmencioğlu

Seçkin

2018

Akademik Gastroenteroloji Dergisi

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“…We appreciate the letter from Yanqing et al, 1 which raised several concerns about our study 2 . First, we definitely agree that serum hepatitis B s antigen (HBsAg) is significantly associated with the risk of hepatocellular carcinoma (HCC) development, as proven in REAVAL‐HBV and ERADICATE‐B studies 3 . In both studies, serum HBsAg and hepatitis B virus (HBV) DNA levels independently predicted the risk of HCC development.…”

mentioning

confidence: 78%

Authors’ response: Additional more factors should be included in predicting risk of hepatocellular carcinoma in patients with chronic hepatitis B virus infection

Chang

Kim

2020

Journal of Viral Hepatitis

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Correlation between IL-35 and viral load in patients with liver hepatitis type B in Baghdad

J. Hammood,

A. Gharbi,

AbdulKareem A. Razzaq

2023

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Hepatitis, including autoimmune hepatitis, alcoholic hepatitis, drug-induced hepatitis, bacterial hepatitis, viral hepatitis, and others, was a typical occurrence in clinical work. Hepatitis B virus (HBV) and hepatitis C virus (HCV), both non-cytopathic viruses, were shown to be frequent in liver damage. It has been observed that IL-35 is linked to a reduction in inflammation and can limit T-cell proliferation and the activity of its effector cells. The hepatitis B virus is a virus that causes liver disease. Serum IL-35 was shown to be higher in chronic hepatitis B virus patients. At the same time, research has discovered that Tregs and other cell types (such as activated myeloid, endothelial cells, and regulatory B cells) can secrete IL-35. The quantity of specific viral DNA or RNA in a blood sample is known as viral load count, and it is one of the potential biomarkers of hepatitis. A high viral load suggests that the immune system has failed to combat viruses. Real-time quantification of hepatitis B (HBV) DNA viral load is possible. Hepatic chronic, cirrhosis, and undetected patients are measured using polymerase chain reaction (PCR) and non-invasive methods. In the ordinary course of HBV infection, HBV DNA is the only thing that survives. HBV DNA levels represent viral levels and derive from mature infectious particles. Reproducibility. Various hospital-based and community-based case-control and cohort studies have repeatedly demonstrated substantial correlations between blood HBV DNA levels and the risk of liver cirrhosis and HCC. Chronic hepatitis B has a variable course in disease activity with a risk of clinical complications like liver cirrhosis and hepatocellular carcinoma. As clinical symptoms present in a late stage of the disease, identifying risk factors is important for early detection and, therefore, improving prognosis. Recently, two REVEAL-HBV studies from Iraq have shown a positive correlation between viral load at any point in time and the development of cirrhosis and hepatocellular carcinoma. Keywords: Hepatitis B virus HBV, Interleukin-35 IL-35, polymerase chain reaction PCR.

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Quantitative hepatitis B surface antigen predicts the antiviral response and hepatocellular carcinoma development in patients with chronic hepatitis B

Cited by 3 publications

References 14 publications

Sirozlu hastalarda Child-Pugh evresine göre Hepatit B Virüs DNA seviyeleri

Sirozlu hastalarda Child-Pugh evresine göre Hepatit B Virüs DNA seviyeleri

Authors’ response: Additional more factors should be included in predicting risk of hepatocellular carcinoma in patients with chronic hepatitis B virus infection

Correlation between IL-35 and viral load in patients with liver hepatitis type B in Baghdad

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