Quantitative evaluation of fatty liver by computed tomography in rabbits

Quantification of the Fat Fraction in the Liver Using Dual-Energy Computed Tomography and Multimaterial Decomposition

“…However, although the degree of hepatic steatosis can be estimated by measuring the hepatic attenuation coefficient, 25,27,44,45 there are some limitations in the quantification of HFF using SECT. First, there were different CT attenuation values when CT scanning was performed at different energy levels in the same liver.…”

“…The degree of decrease in CT attenuation has also been shown to be related to the degree of fatty infiltration of the liver. [23][24][25][26][27][28] However, CT has low sensitivity for detecting mild to moderate hepatic steatosis, 29 and hemosiderin deposition can preclude an accurate assessment of hepatic steatosis based on CT attenuation. 30,31 Meanwhile, recent studies demonstrated that dual-energy CT (DECT) could be used to evaluate hepatic steatosis by measuring the change in hepatic attenuation between images acquired at the lower and higher energy levels 28,[32][33][34] and that 2-material decomposition (MD) with basic materials of fat and liver will be able to similarly quantify the degree of hepatic steatosis.…”

Non-invasive assessment and quantification of liver steatosis by ultrasound, computed tomography and magnetic resonance

“…Since the introduction of computed tomography (CT) in the 1970s, the use of CT in diagnosis of hepatic steatosis has been evaluated by various investigators [64][65][66]. CT provides an accurate and a reliable visualization of the whole liver, so that not only diffuse but also focal fatty infiltrations of the liver parenchyma can be accurately diagnosed.…”

Diagnosis of fatty infiltration of the liver on contrast enhanced CT: limitations of liver-minus-spleen attenuation difference measurements

“…Liver density as measured by CT attenuation units on noncontrast CT (NCCT) has been shown to be related in an inverse-linear fashion to the degree of fatty infiltration [1][2][3]. Unfortunately, measurement of absolute liver attenuation to diagnose fatty infiltration has proven impractical because of wide interpatient and interscanner variation in liver CT attenuation values.…”