“…As briefly mentioned, syndecans, of which there are four members, and glypicans, of which there are six members, comprise the two biggest families of HSPGs expressed on cell surfaces (Iozzo 2001a). Of note, syndecan-1, -2, and -4 have been implicated in certain ocular diseases (Bacsa et al 2011; Bartlett et al 2007; Hayashida et al 2011; Park et al 2004; Regatieri et al 2010) and their specific roles will be discussed in further detail later in this review. Others, such as perlecan, agrin, and collagen XVIII, comprise those HSPGs found in the ECM.…”