Quantitative Evaluation of Biologic Therapy Options for Psoriasis: A Systematic Review and Network Meta-Analysis–Correction

Smith, Catherine; Yiu, Zenas Z N; Bale, Tracy; Burden, A. David; Coates, Laura C.; McGuire, Arlene; Murphy, Ruth; Owen, Caroline M.; Parslew, Richard; Uthman, Olalekan A.; Woolf, Richard; Manounah, L; Ezejimofor, Martinsixtus C.; Exton, L.S.; Mustapa, M.F. Mohd

doi:10.1016/j.jid.2020.02.048

Cited by 6 publications

(5 citation statements)

References 2 publications

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“…A total of 10 analyses were excluded for the following reasons: insufficient information on the compared therapies in the abstract, the absence of the full text [ 28 , 29 , 30 ], the full text being in a language other than English [ 31 ], being a comparison to a placebo [ 32 , 33 , 34 , 35 , 36 ], or the absence of a direct comparison between therapies [ 37 ]. Two older versions or corrections of older MAs were also excluded [ 38 , 39 ] ( Figure 1 ).…”

Section: Resultsmentioning

confidence: 99%

Comparing Meta-Analyses with ChatGPT in the Evaluation of the Effectiveness and Tolerance of Systemic Therapies in Moderate-to-Severe Plaque Psoriasis

Lam Hoai,

Simonart

2023

JCM

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Background: Meta-analyses (MAs) and network meta-analyses (NMAs) are high-quality studies for assessing drug efficacy, but they are time-consuming and may be affected by biases. The capacity of artificial intelligence to aggregate huge amounts of information is emerging as particularly interesting for processing the volume of information needed to generate MAs. In this study, we analyzed whether the chatbot ChatGPT is able to summarize information in a useful fashion for providers and patients in a way that matches up with the results of MAs/NMAs. Methods: We included 16 studies (13 NMAs and 3 MAs) that evaluate biologics (n = 6) and both biologic and systemic treatment (n = 10) for moderate-to-severe psoriasis, published between January 2021 and May 2023. Results: The conclusions of the MAs/NMAs were compared to ChatGPT’s answers to queries about the molecules evaluated in the selected MAs/NMAs. The reproducibility between the results of ChatGPT and the MAs/NMAs was random regarding drug safety. Regarding efficacy, ChatGPT reached the same conclusion as 5 out of the 16 studies (four out of four studies when three molecules were compared), gave acceptable answers in 7 out of 16 studies, and was inconclusive in 4 out of 16 studies. Conclusions: ChatGPT can generate conclusions that are similar to MAs when the efficacy of fewer drugs is compared but is still unable to summarize information in a way that matches up to the results of MAs/NMAs when more than three molecules are compared.

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Section: Resultsmentioning

confidence: 99%

Comparing Meta-Analyses with ChatGPT in the Evaluation of the Effectiveness and Tolerance of Systemic Therapies in Moderate-to-Severe Plaque Psoriasis

Lam Hoai,

Simonart

2023

JCM

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“…52 Wochen) vor, die keine neuen Sicherheitsbedenken erbracht haben. In Metaanalysen von Studiendaten bei erwachsenen Psoriasispatienten mit PASI90-Ansprechen war die Rate schwerer Nebenwirkungen, v. a. schwerer Infektionen, und solcher, die zu einem Therapieabbruch führten, bei Ixekizumab deutlich höher als bei Secukinumab [ 24 , 25 ].…”

Section: Systemtherapie Mit Biologikaunclassified

Psoriasis in children and adolescents

Hamm

Höger

2023

Dermatologie

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Die Psoriasis wird heute als multifaktorielle, entzündliche, immunmediierte Systemerkrankung mit vorrangiger Manifestation am Hautorgan aufgefasst. In etwa einem Drittel der Fälle beginnt sie bereits im Kindes- und Jugendalter und geht oft mit einer deutlichen Beeinträchtigung der Lebensqualität Betroffener und ihrer Eltern einher. Neben der genetischen Disposition sind Triggerfaktoren wie Streptokokkeninfektionen maßgeblich an der Manifestation und an Exazerbationen beteiligt. Auch die bereits in dieser Altersgruppe nachteilige Rolle von Komorbiditäten, allen voran die Adipositas, wurde inzwischen gut belegt. Die Behandlungsmöglichkeiten haben sich durch die Zulassung von nunmehr 5 Biologika im Kindesalter erheblich verbessert, werden aber noch unzureichend genutzt. Der vorliegende Beitrag gibt einen kurzen Überblick über den heutigen Wissensstand und die Empfehlungen der aktualisierten deutschen Leitlinie. Neben den häufigen Typen werden auch ungewöhnlichere Erscheinungsformen wie die pustulöse, die ekzematisierte und die durch TNF(Tumornekrosefaktor)-α-Inhibitoren induzierte „paradoxe“ Psoriasis thematisiert.

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“…The disease is clinically characterized with the presence of scaly skin plaques, arthritis, and an inflammatory cell-rich cutaneous microenvironment (1). It is widely accepted that the interleukin (IL)-23/IL-17 axis plays a vital role in psoriasis development (2), as antibodies targeting IL-12/23 and IL-17 have revolutionized psoriasis treatment (3). Environmental and psychological stressors can exacerbate the symptoms of psoriasis and provoke flares.…”

Section: Introductionmentioning

confidence: 99%

Nociceptive Sensory Fibers Drive Interleukin-23 Production in a Murine Model of Psoriasis via Calcitonin Gene-Related Peptide

et al. 2021

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Neuroimmunity is involved in the pathogenesis of psoriasis, but the mechanism underlying the interaction between the nervous system and the interleukin (IL)-23/IL-17 immune axis is yet unclear. This study reveals the essential role of the sensory neuron-derived calcitonin gene-related peptide (CGRP) in imiquimod (IMQ)-induced expression of IL-23. First, we show that the increased nociceptive behavior was consistent with the development of psoriasiform dermatitis, which requires intact sensory innervation. Systemic ultrapotent Transient receptor potential vanilloid 1 (TRPV1) agonist (resiniferatoxin, RTX) treatment-induced sensory denervation resulted in a significant decrease in IL-23 expression in this model, while the recombinant IL-23 treatment induced IL-17A expression was intact after RTX treatment. In addition, IMQ exposure induced a transient increase in CGRP expression in the dorsal root ganglion. The neuron-derived CGRP expression was completely abolished by sensory denervation, thereby downregulating IL-23 expression, which could be reversed through the introduction of CGRP into the denervated dorsal skin. Our results suggest that nociceptive sensory neurons may drive the production of IL-23, resulting in IL-17A production from γδ T cells via the neuropeptide CGRP in the pathology of psoriasis.

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Quantitative Evaluation of Biologic Therapy Options for Psoriasis: A Systematic Review and Network Meta-Analysis–Correction

Cited by 6 publications

References 2 publications

Comparing Meta-Analyses with ChatGPT in the Evaluation of the Effectiveness and Tolerance of Systemic Therapies in Moderate-to-Severe Plaque Psoriasis

Comparing Meta-Analyses with ChatGPT in the Evaluation of the Effectiveness and Tolerance of Systemic Therapies in Moderate-to-Severe Plaque Psoriasis

Psoriasis in children and adolescents

Nociceptive Sensory Fibers Drive Interleukin-23 Production in a Murine Model of Psoriasis via Calcitonin Gene-Related Peptide

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