Quantitative evaluation and assessment of peritoneal morphologic changes in peritoneal dialysis patients

Shimaoka, Tetsutaro; Hamada, Chikuma; Kaneko, Kayo; Io, Hiroaki; Sekiguchi, Y.; Aruga, Seiki; Inuma, Jiro; Inami, Yuko; Hotta, Yoko; Horikoshi, Satoshi; Kumasaka, Takashi; Tomino, Yasuhiko

doi:10.1093/ndt/gfq194

Cited by 31 publications

(34 citation statements)

References 19 publications

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“…Five points were randomly selected for the measurement using the Kontron KS400 Imaging System (Kontron Elektronik GmbH, Eching, Germany) (15). The average was calculated for each specimen.…”

Section: Histological Analysismentioning

confidence: 99%

Oral Astaxanthin Supplementation Prevents Peritoneal Fibrosis in Rats

et al. 2015

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Section: Histological Analysismentioning

confidence: 99%

Oral Astaxanthin Supplementation Prevents Peritoneal Fibrosis in Rats

et al. 2015

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“…4 Vascular density was measured by counting vessels within SMC area of more 0.3 mm 2 . The number was divided by total SMC (mm 2 ) and mesothelial surface length (mm).…”

Section: Pathological Analysismentioning

confidence: 99%

“…1,2 Major complications are infectious peritonitis episodes, and highly fatal encapsulating peritoneal sclerosis (EPS). [1][2][3][4][5] EPS is a devastating clinical syndrome characterized by fibrosis of peritoneal membrane and is associated with adhesive obstruction of bowel loops (cocooning), weight loss, malnutrition, and hemorrhagic ascites. Overall the incidence of EPS in PD patients is stable at 1-3%.…”

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confidence: 99%

“…3,5,8,9 The pathologic culprit is epithelial-to-mesenchymal transition (EMT) of mesothelial cells that results in tissue remodeling from an inflammatory to a fibrotic state. 4,[10][11][12] Major stimulatory factors are proinflammatory cytokines (TNF-α, IL-1β, IL-6, IL-18), transforming growth factor-β1 (TGF-β1), and vascular endothelial growth factor (VEGF). [10][11][12][13][14][15] Fibrosis itself constitutes a hypoxic environment that also directly up-regulates TGF-β1 and induces angiogenesis via hypoxia-inducible factors (HIF).…”

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confidence: 99%

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The Effect of Steroid-Sirolimus Combination on the Experimental Model of Encapsulating Peritoneal Sclerosis in Rats

Ersan¹,

Çelik²,

Çelik³

et al. 2015

Turkiye Klinikleri J Nephrol

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A AB BS S T TR RA AC CT T O Ob bj je ec ct ti iv ve e: : Encapsulating peritoneal sclerosis (EPS) is a devastating complication of peritoneal dialysis terminating with peritoneal sclerosis and coccooning of intestinal loops. The inhibitors of mammalian target of rapamycin (mTOR), everolimus and sirolimus, have attenuated EPS findings in experimental animal models. The effect of combination of sirolimus with steroid has not been documented so far. The aim of the study was to determine the effect of combination of sirolimus and steroid on experimental sclerosing peritonitis model. M Ma at te er ri ia al l a an nd d M Me et th ho od ds s: : 41 wistar albino male rats were divided into 6 groups : control group (C; isotonic saline injected intraperitoneally), chlorhexidine gluconate group (CG; model group), resting group (R; CG then peritoneal rest, prednisolone group (P; CG then prednisolone), sirolimus group (Sir; CG then sirolimus), and prednisolone-sirolimus group (P-Sir; CG then prednisolone plus sirolimus). Peritoneal specimens obtained after sacrification at the end of study were examined for peritoneal thickness, fibrosis, and vascular intensities under light microscopy. R Re es su ul lt ts s: : In the CG and R groups there was a significant increase in peritoneal thickness, fibrosis score and vascular intensity compared to C, P, Sir, and P-Sir groups in both parietal and visceral peritoneum (p<0.05). The parameters at the end of the study were not different in C, P, Sir, and P-Sir groups. The difference between P, Sir, and P-Sir groups were not significant. Resting was shown to be ineffective in attenuating EPS parameters. C Co on nc cl lu us si io on n: : In this study we observed that sirolimus-prednisolone combination was equally effective in experimental EPS model compared to prednisolone and sirolimus only regimens.K Ke ey y W Wo or rd ds s: : Peritonitis; sirolimus; models, animal; adrenal cortex hormones; peritoneal dialysis Ö ÖZ ZE ET T A Am ma aç ç: : Enkapsüle periton sklerozu (EPS), periton sklerozu ve intestinal segmentlerin koza şeklinde sarılması ile sonuçlanan ciddi bir periton diyalizi komplikasyonudur. Memelilerde rapamisin hedefi inhibitörleri (mTOR), everolimus ve sirolimus, deneysel hayvan modellerinde EPS bulgularını azaltmışlardır. Steroid-sirolimus kombinasyonunun etkisine yönelik yapılan bir çalışma bulunmamaktadır. Bu çalışmada deneysel sklerozon peritorit modelinde sirolimus ile steroid kombinasyon tedavisinin etkisini belirlemek amaçlanmıştır. G Ge er re eç ç v ve e Y Yö ön nt te em ml le er r: : 41 wistar albino erkek sıçan 6 gruba ayrıldı: kontrol grubu (C; intraperitoneal izotonik serum), klorheksidin glukonat grubu (CG; model grup), dinlenme grubu (R; CG sonrası periton dinlenme), prednizolon grubu (P; CG sonrası prednizolon), sirolimus grubu (Sir; CG sonrası sirolimus) ve prednizolon-sirolimus grubu (P-Sir; CG sonrası prednizolon ve sirolimus). Periton örnekleri ışık mikroskobisi ile; periton kalınlığı, fibrozis skoru ve damar yoğunluğu için değerlendirildi. B Bu ul lg gu ul l...

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“…However, long-term PD frequently produces morphological and functional changes of the peritoneum, making continuation of PD difficult. [4][5][6][7][8] Moreover, progression of peritoneal injury causes serious complications, such as encapsulating peritoneal sclerosis. 9) Therefore, it is necessary to evaluate peritoneal injury at an early stage and develop appropriate treatments for peritoneal injury.…”

mentioning

confidence: 99%

Evaluation for Peritoneal Injury at an Early Stage Using Dual Macromolecular Markers

Hirata

Fumoto

Miyamoto

et al. 2016

Biological & Pharmaceutical Bulletin

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Long-term peritoneal dialysis (PD) frequently produces morphological and functional changes of the peritoneum, making continuation of PD difficult. Therefore, it is necessary to evaluate peritoneal injury at an early stage and develop appropriate therapies. The aims of the present study were to evaluate peritoneal injury at an early stage and assess a drug for prevention of peritoneal injury using our previously developed novel evaluation method.

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Quantitative evaluation and assessment of peritoneal morphologic changes in peritoneal dialysis patients

Cited by 31 publications

References 19 publications

Oral Astaxanthin Supplementation Prevents Peritoneal Fibrosis in Rats

Oral Astaxanthin Supplementation Prevents Peritoneal Fibrosis in Rats

The Effect of Steroid-Sirolimus Combination on the Experimental Model of Encapsulating Peritoneal Sclerosis in Rats

Evaluation for Peritoneal Injury at an Early Stage Using Dual Macromolecular Markers

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