Quantitative Estimation of Tissue Prostate Specific Antigen, Deoxyribonucleic Acid Ploidy and Cytological Grade in Fine Needle Aspiration Biopsies for Prognosis of Hormonally Treated Prostatic Carcinoma

Hormone resistant prostatic adenocarcinoma. An evaluation of prognostic factors in pre- and post-treatment specimens

“…Qiu and associates (Qiu et al, 1990) demonstrated a significant decrease in PSA mRNA expression in carcinoma tissue when compared with benign prostatic epithelium. Reduced PSA concentrations have also been found in carcinoma tissue by biochemical methods (Stege et al, 1990;Pretlow et al, 1991;Stege et al, 1992). This is in agreement with our findings.…”

Double‐fluorescence image microscopy for quantitation of prostate‐specific antigen in histologic sections of the prostate

“…This has also been described in biochemical investigations (11)(12)(13). In a prospective study of 179 hormonally treated patients with prostate carcinoma, tissue PSA was the dominating prognostic factor.…”

“…With the decrease in tissue PSA, S-PSA increased significantly (11). A low level of tissue PSA was associated with poor prognosis in hormonally treated patients (12,13). By using molecular biological techniques, the same cDNA sequence of tissue PSA was found in benign and malignant tissue (14).…”

“…Cytosolic tissue PSA has been quantified by the RIA technique from fine-needle aspiration biopsies of patients with benign and malignant lesions (11)(12)(13). A decrease in tissue PSA was related significantly to an increase in tumor stage, grade, and to the shift from a diploid to an aneuploid DNA pattern.…”

Prostate‐specific antigen in tissue from fine‐needle aspiration biopsies

“…In a separate study [10]. the progno tic "alue of IC-PSA was compared with other marker in 67 patients with newly detected pro tatk carcinoma.…”