Quantitative elucidation of maternal-to-fetal transfer of neonicotinoid pesticide clothianidin and its metabolites in mice

Ohno, Shuji; Ikenaka, Yoshinori; Onaru, Kanoko; Kubo, Shizuka; Sakata, Nanami; Hirano, Tetsushi; Mantani, Youhei; Yokoyama, Toshifumi; Takahashi, Keisuke; Kato, Kanefusa; Arizono, Koji; Ichise, Takahiro; Nakayama, Shouta M.M.; Ishizuka, Mayumi; Hoshi, Nobuhiko

doi:10.1016/j.toxlet.2020.01.003

Cited by 26 publications

(21 citation statements)

References 27 publications

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“…Another NN, imidacloprid, has been reported to cause significant changes in ovarian morphology and in follicle stimulating hormone (FSH), luteinizing hormone (LH), and progesterone levels in female rats [ 21 ] and to decrease testosterone levels in male rats [ 12 ]. We recently reported that CLO passes rapidly through the placental barrier in mice [ 27 ]. It has also been shown that in utero and lactational exposure to CLO decrease the numbers of germ cells in male mice [ 44 ].…”

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confidence: 99%

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Effects of <i>in utero</i> and lactational exposure to the no-observed-adverse-effect level (NOAEL) dose of the neonicotinoid clothianidin on the reproductive organs of female mice

et al. 2021

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Recently, developmental exposure to clothianidin (CLO) has been shown to cause reproductive toxicity in male mice, but the effects in female mice remain to be clarified. Pregnant C57BL/6N mice were given a no-observed-adverse-effect-level (NOAEL) dose of CLO until weaning. We then examined ovaries of 3-or 10-week-old female offspring. In the CLO-administered group, morphological changes, a decrease in the immunoreactivity of the antioxidant enzyme glutathione peroxidase 4 (GPx4), and activation of genes in the steroid hormone biosynthesis pathway were observed in 3-week-old mice, and decreases of GPx4 immunoreactivity, 17OH-progesterone and corticosterone levels were observed in 10-week-old mice, along with high rates of infanticide and severe neglect, providing new evidence that developmental exposure to CLO affects juvenile and adult mice differently.

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confidence: 99%

“…C57BL/6NCrSlc pregnant mice were purchased from Japan SLC (Hamamatsu, Japan) and maintained as described elsewhere [ 27 ]. This study was approved by the Institutional Animal Care and Use Committee (Permission #26-05-07) and carried out according to the Kobe University Animal Experimental Regulations.…”

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confidence: 99%

Effects of <i>in utero</i> and lactational exposure to the no-observed-adverse-effect level (NOAEL) dose of the neonicotinoid clothianidin on the reproductive organs of female mice

et al. 2021

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“…Despite the lack of studies on contaminants in actively reproducing female bats and/or their offspring, it is probable that pups can be exposed in utero based upon numerous studies in humans and other mammals documenting placental transfer of commonly sold pesticides including neonicotinoids [58][59][60]. Furthermore, because pesticides and their metabolites are often detected in mammalian milk [61][62][63], pups are likely exposed to pesticides for approximately 3-4 weeks after birth while nursing.…”

Section: Reproductionmentioning

confidence: 99%

Pesticide Exposure Risks to Chiropteran Species and the Impacts on Emerging Zoonotic Diseases

Hooper¹,

Amelon²

2022

Bats - Disease-Prone but Beneficial

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Neonicotinoids have been in the spotlight in the pollinator community as they persist in the soil, have high water solubility, and have been associated with negative health implications on insect pollinators. The risk of new novel pesticides, including neonicotinoids, to bats are largely unknown. Bats have unique physiology as they are the only mammals capable of true and sustained flight, and have physiological adaptations including echolocation and torpor which under current protocols for acute and chronic toxicity studies in birds and terrestrial animals are not assessed. Due to these characteristics, some have argued that bats may serve as important bioindicators for ecosystem health and pesticide use. This chapter will focus on pesticides, and discuss the increased risk of exposure, morbidity, and mortality of bats species due to their unique physiology and natural life history. Special emphasis will be on potential increased risk of zoonotic disease transmission in bats exposed to emerging contaminants that suppress their immune system or cause increased biological stress.

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“…It appears that current environmental concentrations of NNs are relatively low and may not pose a health risk to adult humans. However, they could pose a risk to fetuses, as human and rodent studies have shown that both NNs and their metabolites can be transferred rapidly through the placenta and accumulate in the fetus [57,250,252]. Since during brain development the BBB of fetuses and neonates is immature, this will facilitate the penetration and accumulation of different chemicals, such as pesticides, in their brain [253].…”

Section: Relevance Of Daily Human Exposure To Pesticides Nnsmentioning

confidence: 99%

Neurotoxic Effects of Neonicotinoids on Mammals: What Is There beyond the Activation of Nicotinic Acetylcholine Receptors?—A Systematic Review

Costas-Ferreira

Faro

2021

IJMS

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Neonicotinoids are a class of insecticides that exert their effect through a specific action on neuronal nicotinic acetylcholine receptors (nAChRs). The success of these insecticides is due to this mechanism of action, since they act as potent agonists of insect nAChRs, presenting low affinity for vertebrate nAChRs, which reduces potential toxic risk and increases safety for non-target species. However, although neonicotinoids are considered safe, their presence in the environment could increase the risk of exposure and toxicity. On the other hand, although neonicotinoids have low affinity for mammalian nAChRs, the large quantity, variety, and ubiquity of these receptors, combined with its diversity of functions, raises the question of what effects these insecticides can produce in non-target species. In the present systematic review, we investigate the available evidence on the biochemical and behavioral effects of neonicotinoids on the mammalian nervous system. In general, exposure to neonicotinoids at an early age alters the correct neuronal development, with decreases in neurogenesis and alterations in migration, and induces neuroinflammation. In adulthood, neonicotinoids induce neurobehavioral toxicity, these effects being associated with their modulating action on nAChRs, with consequent neurochemical alterations. These alterations include decreased expression of nAChRs, modifications in acetylcholinesterase activity, and significant changes in the function of the nigrostriatal dopaminergic system. All these effects can lead to the activation of a series of intracellular signaling pathways that generate oxidative stress, neuroinflammation and, finally, neuronal death. Neonicotinoid-induced changes in nAChR function could be responsible for most of the effects observed in the different studies.

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Quantitative elucidation of maternal-to-fetal transfer of neonicotinoid pesticide clothianidin and its metabolites in mice

Cited by 26 publications

References 27 publications

Effects of <i>in utero</i> and lactational exposure to the no-observed-adverse-effect level (NOAEL) dose of the neonicotinoid clothianidin on the reproductive organs of female mice

Effects of <i>in utero</i> and lactational exposure to the no-observed-adverse-effect level (NOAEL) dose of the neonicotinoid clothianidin on the reproductive organs of female mice

Pesticide Exposure Risks to Chiropteran Species and the Impacts on Emerging Zoonotic Diseases

Neurotoxic Effects of Neonicotinoids on Mammals: What Is There beyond the Activation of Nicotinic Acetylcholine Receptors?—A Systematic Review

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