Quantitative DTI Assessment in Human Lumbar Stabilization Muscles at 3 T

Jones, Gavin E. G.; Kumbhare, Dinesh; Harish, Srinivasan; Noseworthy, Michael D.

doi:10.1097/rct.0b013e3182772d66

Cited by 7 publications

(6 citation statements)

References 35 publications

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“…Galban et al found a significantly higher diffusivity in muscles of female subjects as compared to males; however, no clear explanation could be given. Moreover, these findings seem to be more pronounced in the flexor muscles, but cannot be reproduced by others . With respect to age, an overall decrease in diffusivity and increase in FA values in calf muscles has been found with increasing age, which is hypothesized to be caused by age‐induced atrophy .…”

Section: Feasibility Studies and Reported Variances In Healthy Skeletmentioning

confidence: 99%

“…Moreover, these findings seem to be more pronounced in the flexor muscles, but cannot be reproduced by others. 17,94,99 With respect to age, an overall decrease in diffusivity and increase in FA values in calf muscles has been found with increasing age, which is hypothesized to be caused by age-induced atrophy. 88 However, reported changes differ per muscle(-group) (flexors/ extensors or lower/upper extremities), sometimes are absent, or contradictory between studies.…”

Section: Sensitivity To Demographic Factorsmentioning

confidence: 99%

“…Thereafter, it was hypothesized that changes in joint position, which lead to muscle shortening or lengthening, would lead to changes in muscle architecture and therefore in DTI parameters as well. For the ankle this was addressed in several studies, 19 (15,17,85,99) " (16,85) 5 (17,19,94,99) Mostly unclear.…”

Section: Transient Factors and Joint Positionmentioning

confidence: 99%

“…Ageing " (15,88,94,100) 5 (17,99) 5 (17,99) # (15,88,94,100) Reduced fiber diameter due to age-induced atrophy. Changes in type 1 and 2 fiber composition.…”

Section: Transient Factors and Joint Positionmentioning

confidence: 99%

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Techniques and applications of skeletal muscle diffusion tensor imaging: A review

Oudeman

Nederveen

Strijkers

et al. 2015

J. Magn. Reson. Imaging

150

153

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Diffusion tensor imaging (DTI) is increasingly applied to study skeletal muscle physiology, anatomy, and pathology. The reason for this growing interest is that DTI offers unique, noninvasive, and potentially diagnostically relevant imaging readouts of skeletal muscle structure that are difficult or impossible to obtain otherwise. DTI has been shown to be feasible within most skeletal muscles. DTI parameters are highly sensitive to patient-specific properties such as age, body mass index (BMI), and gender, but also to more transient factors such as exercise, rest, pressure, temperature, and relative joint position. However, when designing a DTI study one should not only be aware of sensitivity to the above-mentioned factors but also the fact that the DTI parameters are dependent on several acquisition parameters such as echo time, b-value, and diffusion mixing time. The purpose of this review is to provide an overview of DTI studies covering the technical, demographic, and clinical aspects of DTI in skeletal muscles. First we will focus on the critical aspects of the acquisition protocol. Second, we will cover the reported normal variance in skeletal muscle diffusion parameters, and finally we provide an overview of clinical studies and reported parameter changes due to several (patho-)physiological conditions.

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Section: Feasibility Studies and Reported Variances In Healthy Skeletmentioning

confidence: 99%

Section: Sensitivity To Demographic Factorsmentioning

confidence: 99%

Section: Transient Factors and Joint Positionmentioning

confidence: 99%

“…Ageing " (15,88,94,100) 5 (17,99) 5 (17,99) # (15,88,94,100) Reduced fiber diameter due to age-induced atrophy. Changes in type 1 and 2 fiber composition.…”

Section: Transient Factors and Joint Positionmentioning

confidence: 99%

See 2 more Smart Citations

Techniques and applications of skeletal muscle diffusion tensor imaging: A review

Oudeman

Nederveen

Strijkers

et al. 2015

J. Magn. Reson. Imaging

150

153

View full text Add to dashboard Cite

show abstract

“…Examination of muscle architecture noninvasively to gain insight into the underlying fibre structure has been carried out for over a decade using diffusion tensor imaging [83][84][85][86][87][88][89][90][91][92][93]. While earlier DTI studies were performed in the brain to assess the integrity of cerebral structures [94,95], the technique was quickly applied to investigate skeletal muscles due to the anisotropic muscle fibre structure.…”

Section: Other Advanced Structural and Functional Mri Techniques Diffmentioning

confidence: 99%

Advanced Skeletal Muscle MR Imaging Approaches in the Assessment of Muscular Dystrophies

Kumbhare¹,

Elzibak²,

Akbari³

et al. 2014

Int J Phys Med Rehabil

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Muscular dystrophies (MDs) are inherited diseases that lead to progressive skeletal muscle weakness and functional decline. Currently, the diagnosis is generally made on clinical grounds and confirmed by genetic testing, serologic assessments, neurophysiologic measurements or muscle biopsy. Given our understanding of the pathophysiology of these dystrophies, advancements in magnetic resonance imaging (MRI) techniques may assist clinicians in identification and monitoring of skeletal muscle disease progression in MDs using non-invasive approaches. In this article, we review MR imaging techniques that have been used to quantify skeletal muscle involvement in the various muscle dystrophies, such as in vivo spectroscopic procedures to quantify lipids (1H), muscle bioenergetics (31P) or cellular function (23Na). We also summarize studies that have used T2 relaxation measurements to evaluate muscular dystrophies. While carbon spectroscopy (13C), diffusion tensor imaging (DTI) and blood oxygenation level-dependent (BOLD) imaging have not yet been explored in the assessment of skeletal muscles of MD patients, we briefly describe these techniques as they have been useful in skeletal muscle examinations of healthy and injured muscles. Thus, they could potentially be of diagnostic and prognostic value in skeletal muscle evaluations of MD patients. The article concludes by commenting on potential for image processing methods such as texture analysis in the evaluation of muscle images from MD patients.

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Multiparametric MRI characterization of level dependent differences in lumbar muscle size, quality, and microstructure

et al. 2020

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Magnetic resonance imaging (MRI) is a diagnostic tool that can be used to noninvasively assess lumbar muscle size and fatty infiltration, important biomarkers of muscle health. Diffusion tensor imaging (DTI) is an MRI technique that is sensitive to muscle microstructural features such as fiber size (an important biomarker of muscle health), which is typically only assessed using invasive biopsy techniques. The goal of this study was to establish normative values of level‐dependent lumbar muscle size, fat signal fraction, and restricted diffusion assessed by MRI in a highly active population. Forty‐two active‐duty Marines were imaged using a (a) high‐resolution anatomical, (b) fat‐water separation, and (c) DT‐MRI scan. The multifidus and erector spinae muscles were compared at each level using two‐way repeated measures ANOVA. Secondary analysis included Three dimensional (3D) reconstructions to qualitatively assess lumbar muscle size, fatty infiltration, and fiber orientation via tractography. The erector spinae was found to be larger than the multifidus above L5, with lower fat signal fraction above L3, and a less restricted diffusion profile than the multifidus above L4, with this pattern reversed in the lower lumbar spine. 3D reconstructions demonstrated accumulations of epimuscular fat in the anterior and posterior regions of the lumbar musculature, with minimal intramuscular fatty infiltration. Tractography images demonstrated different orientations of adjacent lumbar musculature, which cannot be visualized with standard MRI pulse sequences. The level dependent differences found in this study provide a normative baseline, for which to better understand whole muscle and microstructural changes associated with aging, low back pain, and pathology.

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Quantitative DTI Assessment in Human Lumbar Stabilization Muscles at 3 T

Abstract: The DTI metrics in paraspinal muscles can be reliably measured and are influenced by body mass index and weight but not by age or physical activity.

Cited by 7 publications

References 35 publications

Techniques and applications of skeletal muscle diffusion tensor imaging: A review

Techniques and applications of skeletal muscle diffusion tensor imaging: A review

Advanced Skeletal Muscle MR Imaging Approaches in the Assessment of Muscular Dystrophies

Multiparametric MRI characterization of level dependent differences in lumbar muscle size, quality, and microstructure

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