Advanced Skeletal Muscle MR Imaging Approaches in the Assessment of Muscular Dystrophies

Kumbhare, Dinesh; Elzibak, Alyaa H.; Akbari, Alireza; Noseworthy, Michael D.

doi:10.4172/2329-9096.1000248

Cited by 6 publications

(7 citation statements)

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“…Recent advancements in quantitative MRI have significantly expanded the potential to evaluate pathologic changes in muscle disorders, including composition, architecture, mechanical properties, perfusion, and function. [1][2][3][4][5] Semi-quantitative methods can assess and grade the extension of compositional changes such as fatty degeneration. 1 Moreover, it has been shown that T 1 relaxation significantly decreased with fat infiltration and increased with edema.…”

Section: Introductionmentioning

confidence: 99%

Simultaneous T₁, T₂, and T_1ρ relaxation mapping of the lower leg muscle with MR fingerprinting

Sharafi

Medina

Zibetti

et al. 2021

Magnetic Resonance in Med

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To develop a novel MR-fingerprinting (MRF) pulse sequence that is insensitive to B + 1 and B 0 imperfections for simultaneous T 1 , T 2 , and T 1ρ relaxation mapping. Methods: We implemented a totally balanced spin-lock (TB-SL) module to encode T 1ρ relaxation into an existing MRF framework that encoded T 1 and T 2. The spin-lock module used two 180° pulses with compensatory phases to reduce T 1ρ sensitivity to B 1 and B 0 inhomogeneities. We compared T 1ρ measured using TB-SL MRF in Bloch simulations, model agar phantoms, and in vivo experiments to those with a self-compensated spin-lock preparation module (SC-SL). The TB-SL MRF repeatability was evaluated in maps acquired in the lower leg skeletal muscle of 12 diabetic peripheral neuropathy patients, scanned two times each during visits separated by about 30 days. Results: The phantom relaxation times measured with TB-SL and SC-SL MRF were in good agreement with reference values in regions with low B 1 inhomogeneities. Compared with SC-SL, TB-SL MRF showed in experiments greater robustness against severe B 1 inhomogeneities and in Bloch simulations greater robustness against B 1 and B 0. We measured with TB-SL MRF an average T 1 = 950.1 ± 28.7 ms, T 2 = 26.0 ± 1.2 ms, and T 1ρ = 31.7 ± 3.2 ms in skeletal muscle across patients. Bland-Altman analysis demonstrated low bias between TB-SL and SC-SL MRF and between TB-SL MRF maps acquired in two visits. The coefficient of variation was less than 3% for all measurements. Conclusion: The proposed TB-SL MRF sequence is fast and insensitive to B + 1 and B 0 imperfections. It can simultaneously map T 1 , T 2 , T 1ρ , and B + 1 in a single scan and can potentially be used to study muscle composition.

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Section: Introductionmentioning

confidence: 99%

Simultaneous T₁, T₂, and T_1ρ relaxation mapping of the lower leg muscle with MR fingerprinting

Sharafi

Medina

Zibetti

et al. 2021

Magnetic Resonance in Med

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“…Such techniques can effectively provide information beyond what can be seen and assessed at conventional MRI; their development and application in clinical practice can play an important role in defining the disease course and treatment response (27–30).…”

Section: Applications Of Advanced Quantitative Techniquesmentioning

confidence: 99%

Advances in Quantitative Imaging of Genetic and Acquired Myopathies: Clinical Applications and Perspectives

et al. 2019

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In the last years, magnetic resonance imaging (MRI) has become fundamental for the diagnosis and monitoring of myopathies given its ability to show the severity and distribution of pathology, to identify specific patterns of damage distribution and to properly interpret a number of genetic variants. The advances in MR techniques and post-processing software solutions have greatly expanded the potential to assess pathological changes in muscle diseases, and more specifically of myopathies; a number of features can be studied and quantified, ranging from composition, architecture, mechanical properties, perfusion, and function, leading to what is known as quantitative MRI (qMRI). Such techniques can effectively provide a variety of information beyond what can be seen and assessed by conventional MR imaging; their development and application in clinical practice can play an important role in the diagnostic process and in assessing disease course and treatment response. In this review, we briefly discuss the current role of muscle MRI in diagnosing muscle diseases and describe in detail the potential and perspectives of the application of advanced qMRI techniques in this field.

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“…Currently, the diagnosis is generally made on clinical grounds and confirmed by genetic testing, serologic assessments, neurophysiologic measurements, or muscle biopsy [3]. Dystrophic changes in affected muscles usually do not occur randomly but rather develop in a specific pattern [4].…”

Section: Introductionmentioning

confidence: 99%

“…Thus, their use may be limited in the assessment of disease status in muscle dystrophies (MDs), especially because young children are commonly affected and repeated evaluations are necessary due to the tendency of muscles to degenerate over time. An imaging approach is desired in this case [3].…”

Section: Introductionmentioning

confidence: 99%

“…Numerous imaging methods exist to evaluate skeletal muscles in the various MDs and to track disease progression including computed tomography (CT), nuclear medicine (e.g., positron emission tomography, PET and single-photon emission computer tomography, SPECT), ultrasound (US), and magnetic resonance imaging (MRI) [3]. In pediatric populations, the use of nuclear medicine and CT have the disadvantage of exposing patients to ionizing radiation, even though the sensitivity and specificity are notably high (especially for PET) [3].…”

Section: Introductionmentioning

confidence: 99%

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Muscle dystrophies in children

El‐Gamal¹,

Girgis²,

Hashim³

et al. 2022

ijhs

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Muscular dystrophies are a heterogeneous inherited group of disorders characterized by a variable distribution of weakness, various ages of onset, the pattern of inheritance, rate of progression, and clinical severity. Muscle degeneration and regeneration characterize muscle biopsy and these disorders are typically associated with elevated serum creatine kinase. Objective: We wanted to study the clinical characteristics of patients with muscle dystrophies and study clinical and genetic correlation in patients with Duchenne muscular dystrophy. Methods: This cross-sectional descriptive study included a cohort of 60 patients diagnosed with muscular dystrophy and fulfilling the inclusion criteria. All patients were subjected to full history taking and full neurological examination. Results: Patients are divided into five groups to study clinical characteristics in each group. 1. Duchenne muscular dystrophy group: included 30 patients who have genetically confirmed DMD cases (50 %), 2. Limb-girdle muscular dystrophy group: included 23 patients (38.3 %), 3. Myotonic dystrophy group: included 3 patients (5 %), 4. Congenital muscular dystrophy group: included 3 patients who were diagnosed clinically as merosin deficient congenital muscle dystrophy (5 %), 5. Distal dystrophy group: included 1 patient with distal muscle dystrophy (1.7 %). Mean age, gender, age of symptoms onset, main motor symptoms, CPK level, echocardiography.

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Advanced Skeletal Muscle MR Imaging Approaches in the Assessment of Muscular Dystrophies

Cited by 6 publications

References 113 publications

Simultaneous T₁, T₂, and T_1ρ relaxation mapping of the lower leg muscle with MR fingerprinting

Simultaneous T₁, T₂, and T_1ρ relaxation mapping of the lower leg muscle with MR fingerprinting

Advances in Quantitative Imaging of Genetic and Acquired Myopathies: Clinical Applications and Perspectives

Muscle dystrophies in children

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Advanced Skeletal Muscle MR Imaging Approaches in the Assessment of Muscular Dystrophies

Cited by 6 publications

References 113 publications

Simultaneous T1, T2, and T1ρ relaxation mapping of the lower leg muscle with MR fingerprinting

Simultaneous T1, T2, and T1ρ relaxation mapping of the lower leg muscle with MR fingerprinting

Advances in Quantitative Imaging of Genetic and Acquired Myopathies: Clinical Applications and Perspectives

Muscle dystrophies in children

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Product

Resources

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Simultaneous T₁, T₂, and T_1ρ relaxation mapping of the lower leg muscle with MR fingerprinting

Simultaneous T₁, T₂, and T_1ρ relaxation mapping of the lower leg muscle with MR fingerprinting