Quantitative determination of unbound cefoperazone in rat bile using microdialysis and liquid chromatography

Chang, Yuh Lih; Chiou, Shih Hwa; Chou, Yueh Ching; Yen, Chih Ju; Tsai, Tung Hu

doi:10.1016/j.jpba.2007.05.002

Cited by 6 publications

(3 citation statements)

References 38 publications

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“…In addition, urinary recovery of cefoperazone ranged from 15 to 30% with coadministration of sulbactam in healthy subjects, as cefoperazone is essentially excreted unchanged in the bile (Muder et al ., ). Interestingly, a pharmacokinetic study in rat bile using microdialysis was also reported (Chang et al ., ). The estimated pharmacokinetic parameters of bile after intravenous administration of cefoperazone at a dose of 30 mg/kg indicated a mean C max and t 1/2 of 5.4 µg/mL and 64.1 min, respectively.…”

Section: Pharmacokinetic Applications Of Third‐generation Cephalosporinsmentioning

confidence: 97%

Recent bioanalytical methods for quantification of third‐generation cephalosporins using HPLC and LC‐MS(/MS) and their applications in pharmacokinetic studies

Jin

Maeng

2014

Biomedical Chromatography

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Third-generation cephalosporins are semi-synthetic antibiotics with enhanced activity against Gram-negative organisms. The cephalosporins in biological samples are mostly determined using high-performance liquid chromatography (HPLC) and HPLC-mass spectrometry (LC-MS) or tandem mass spectrometry (LC-MS/MS). In recent years, numerous bioanalytical methods have been developed to improve the sensitivity and specificity of cephalosporin quantification using the powerful LC-MS/MS systems that are common in research laboratories. This review article presents recently developed bioanalytical methods by HPLC or LC-MS(/MS) for 12 third-generation cephalosporins, including five oral third-generation cephalosporins, and further discusses their application in pharmacokinetic studies of animals and humans.

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Section: Pharmacokinetic Applications Of Third‐generation Cephalosporinsmentioning

confidence: 97%

Recent bioanalytical methods for quantification of third‐generation cephalosporins using HPLC and LC‐MS(/MS) and their applications in pharmacokinetic studies

Jin

Maeng

2014

Biomedical Chromatography

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“…Chang et al [115,116] used the HPLC analysis coupled with the online microdialysis technique to determine the rats bile duct unbound cefepine pharmacokinetics. The microdialysis probe was implanted into the bile duct, then injected the cefepine intravenously, according to the 50 mg/kg administration, the cefepine in the dialysate solution can be quantification determination.…”

Section: The Pharmacokinetic Study Of the Drugs Excreted By The Gallbmentioning

confidence: 99%

Crosstalk the Microdialysis in Scientific Research: from Principle to its Applications

Lee¹,

Di²

2013

Pharm Anal Acta

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“…Microdialysis, which is easy to operate, rapid, and free or uses less organic solvents, has been applied to isolate components from a sample matrix. Online HPLC with microdialysis perfusion provides simplified sample preparation and has been widely applied to biosamples − , cosmetic samples , wastewater , milk , and fermented drinks . It has the potential to be an alternative to conventional pretreatment processes in the determination of sinigrin in plant samples.…”

Section: Introductionmentioning

confidence: 99%

Determination of Sinigrin in Vegetable Seeds by Online Microdialysis Sampling Coupled to Reverse-Phase Ion-Pair Liquid Chromatography

Teng

Huang²,

Ponnusamy³

et al. 2010

J. Agric. Food Chem.

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A hollow fiber microdialysis sampling coupled online to ion-pair liquid chromatography was investigated as an alternative to sample pretreatment for the direct determination of sinigrin in cruciferous vegetables without desulfation. After microdialysis, the dialysate was online injected into the chromatographic system to analyze the sinigrin with UV detection at 227 nm. Parameters affecting the microdialysis efficiency, such as flow rate, polarity modifier, pH in perfusion stream, pH, and salt added in sample solution, were studied. Through ion suppression in the donor phase and ion-pair formation in the acceptor phase, the microdialysis efficiency of sinigrin was enhanced. Experimental results revealed that the microdialysis of a sample solution (pH 2.0) using 0.1 M tetrabutylammonium (pH 12) as a perfusate at 10 microL/min flow rate maximized the extraction efficiency. Detection was linear in the concentration of 1.0-100 mg/L with a detection limit of 0.3 mg/L. Three seed samples were analyzed, with sinigrin at 49.8 (3.15% RSD), 20.0 (4.43% RSD), and 19.8 mg/g (4.22% RSD) for brussels, cauliflower, and cabbage, respectively. When 40 mg/g sinigrin was spiked in brussels seed powder, the recovery was 102.4% with 3.15% RSD (n = 3). The proposed method was proven to provide a very simple, rapid, and eco-friendly procedure to determine sinigrin in the seeds of cruciferous vegetables.

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Quantitative determination of unbound cefoperazone in rat bile using microdialysis and liquid chromatography

Cited by 6 publications

References 38 publications

Recent bioanalytical methods for quantification of third‐generation cephalosporins using HPLC and LC‐MS(/MS) and their applications in pharmacokinetic studies

Recent bioanalytical methods for quantification of third‐generation cephalosporins using HPLC and LC‐MS(/MS) and their applications in pharmacokinetic studies

Crosstalk the Microdialysis in Scientific Research: from Principle to its Applications

Determination of Sinigrin in Vegetable Seeds by Online Microdialysis Sampling Coupled to Reverse-Phase Ion-Pair Liquid Chromatography

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