Quantitative determination of thebaine in Papaver bracteatum by high-pressure liquid chromatography

GC-MS detection and characterization of thebaine as a urinary marker of opium use

“…In the controlled experiments carried out in our laboratory, which involved burning of the pure thebaine or opium with cigarette tobacco under smokingsimulating conditions, thebaine was neither detected in the residue nor sublimate, which indicated its decomposition. Cassella et al [13] and Wu and Dobberstein [29] also reported a heat effect on decomposition of the alkaloid. On the other hand, thebaine was found to be stable in simulated gastric medium [12].…”

Alkaloid Production From Papaver Tissue Cultures

“…Callus cultures were grown in the dark. -Cultures were extracted by a modification of the procedure of Wu and Dobberstein (17). The cultures were homogenized in a volume of 5% acetic acid corresponding to the fresh weight of cells.…”

Altered gene expression and root thebaine production in polyploidized and methyl jasmonate-elicited Papaver bracteatum Lindl

“…is a wild perennial medicinal plant belonging to the section Oxytona of Papaveraceae family that grows in the Alborz Mountains in the North of Iran at altitudes higher than 1800 m on the slopes facing the Caspian Sea (Sharghi and Lalezari, 1967). It is mainly known for the high amounts of the valuable benzylisoquinoline alkaloid (BIA) thebaine as the main secondary metabolite in roots and capsules (Nyman and Bruhn, 1979), while some 20 other alkaloids are reported to be present at trace amounts only (Wu and Dobberstein, 1977). Thebaine is a secondary metabolite produced through benzylisoquinoline biosynthesis pathway in plant genus Papaver.…”