Quantitative Determination of Sparteine Sulfate

Turi, Paul; Grossman, Dan

doi:10.1002/jps.2600520825

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2019

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“…The mixture was stored at 4 °C for 48 h, filtered, washed with isopropanol, and dried at 60 °C to constant weight, yielding 3.43 g (2.3% dry weight) of (−)-sparteine sulfate as a creamy white powder with a melting . 20 Preparation of (−)-Sparteine Free Base. The organic extracts of several batches of L. montanus plant material were concentrated together and subjected to high-vacuum distillation.…”

Section: ■ Proceduresmentioning

confidence: 99%

Sustainable Process for Sparteine Sulfate Preparation

Regla¹,

López-Ortíz²,

Jiménez³

et al. 2019

Org. Process Res. Dev.

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(−)-Sparteine sulfate is a stable salt of the quinolizidine chiral diamine alkaloid (−)-sparteine. This compound, in addition to presenting various biological activities, has successfully been used as a ligand and organocatalyst in enantioselective lithiation reactions in asymmetric synthesis. (−)-Sparteine free base deteriorates gradually, even in refrigeration, but its stable salt, (−)-sparteine sulfate, offers advantages in handling and storage. To the best of our knowledge, no process exists in the literature for obtaining (−)-sparteine sulfate from the species of the plant genus Lupinus. In this work, we present an efficient and sustainable process to obtain (−)-sparteine sulfate and free base (−)-sparteine from leaves and stems of Lupinus montanus.

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Section: ■ Proceduresmentioning

confidence: 99%