Quantitative determination of pamoic acid in dog and rat serum by automated ion-pair solid-phase extraction and reversed-phase high-performance liquid chromatography

Jørgensen, Martin Grønbech

doi:10.1016/s0378-4347(98)00273-4

Cited by 21 publications

(10 citation statements)

References 9 publications

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“…The former (Fig. 6A) is derived from pamoic acid, which is a common matrix for pharmaceutical preparations [109]; and the later indole derivative (Fig. 6B) partially simulates catabolic metabolites of organisms [110], with both being presumably more biocompatible than those manufactured materials [111].…”

Section: Necrosis-avid Contrast Agents (Nacas): Porphyrin and Nonporpmentioning

confidence: 99%

Metalloporphyrins and Functional Analogues as MRI Contrast Agents

2008

CMIR

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Following the footprint of porphyrin-mediated photodynamic therapy (PDT), paramagnetic metalloporphyrins were originated as tumor seeking contrast agents (CAs) for magnetic resonance imaging (MRI). However, serial research has disproved their tumor selectivity, identified nonviable tissues as their real targets, and eventually elicited new applications in myocardial infarction delineation, tissue viability evaluation, ablation therapy assessment, as well as first pass or dynamic perfusion MRI, multi-organ contrast enhancement (CE), atherosclerotic plaque imaging and stem cell labeling or tracking. Furthermore, nonporphyrin analogues have been developed to reduce porphyrin related toxicities. These porphyrin and nonporphyrin compounds have been termed as necrosis-avid contrast agents (NACAs) to denote their major discovered affinity. The present review aims to document the evolving research in this particular field, to discuss possible mechanisms, to promote further preclinical and clinical development of this unique and promising class of MRI CAs, and to implicate a novel stroma targeting strategy for diagnosis and treatment of malignant and benign disorders.

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Section: Necrosis-avid Contrast Agents (Nacas): Porphyrin and Nonporpmentioning

confidence: 99%

Metalloporphyrins and Functional Analogues as MRI Contrast Agents

2008

CMIR

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“…PA has two 2-naphthol units, which are bridged at position 1 of 2-naphthol by a methylene group, and each naphthol unit contains one carboxylic acid group at position 3. While PA is usually utilized for the salt formation of some drugs [15], it was also used as a ligand for making dinuclear Ti(IV) complexes [16]. However, to the best of our knowledge, PA has never been used to prepare AuNPs.…”

Section: Introductionmentioning

confidence: 99%

Preparation of monodispersed carboxylate-functionalized gold nanoparticles using pamoic acid as a reducing and capping reagent

2014

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A simple preparation method of gold nanoparticles (AuNPs) using pamoic acid (PA; 4,4′-methylene-bis(3-hydroxy-2-naphthalene carboxylic acid)) with NaOH is described. Although PA is insoluble in water, it can be dissolved in the presence of NaOH and function as a capping and reducing reagent to form the AuNPs. The thus-formed AuNPs have a good monodispersity with diameters of 10.8 ±1.2 nm and carboxylate functions that come from the PA. Because PA is a methylene-bridged dimer of 3-hydroxy-2naphthalene carboxylic acid, the formation of the AuNPs was examined also using the analogous monomer molecules, i.e., 3-hydroxy-2-naphthalene carboxylic acid, 2-hydroxy-1-naphtalene carboxylic acid, or 2naphthol. Consequently, it was found that the case of PA was specific to forming the spherical monodispersed AuNPs while that differently shaped Au nanostructures were formed in the other cases. The present preparation using PA would be an interesting example that stable, monodispersed, carboxylate-functionalized AuNPs could be prepared without using thiols. Also, the present results may provide some insight into molecular designs of capping reagents for preparing functionalized AuNPs without using thiol derivatives.

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“…Ion-pairing (IP) reagents have been known and used for their ability to change selectivity and increase retention of polar compounds on reversed-phase (RP) analytical columns [5][6][7][8][9][10][11][12]. Typical IP reagents contain a nonpolar portion, such as a long chain aliphatic hydrocarbon, and a polar portion, such as an acid or base.…”

Section: Introductionmentioning

confidence: 99%